Manteia

ENSDARG00000044688

Danio rerio

Features

Gene ID:	ENSDARG00000044688

Biological name :	dusp4

Synonyms :	dual specificity phosphatase 4 / dusp4

Possible biological names infered from orthology :	Dual specificity protein phosphatase 4 / Q13115 / Q8BFV3

Species:	Danio rerio

Chr. number:	21
Strand:	-1
Band:
Gene start:	20113470
Gene end:	20120543

Corresponding Affymetrix probe sets:	Dr.9304.1.S1_at (Zebrafish Array) NM_201171_at (Zebrafish Genome Array with custom cdf files)

Cross references:	Ensembl peptide - ENSDARP00000065663 NCBI entrez gene - 394146 See in Manteia. RefSeq - NM_201171 RefSeq Peptide - NP_957465 swissprot - Q7SZF3 ZFIN ID - ZDB-GENE-040426-709 Ensembl - ENSDARG00000044688

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
DUSP4	ENSGALG00000011419	Gallus gallus
DUSP4	ENSG00000120875	Homo sapiens
Dusp4	ENSMUSG00000031530	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
dusp1 / dual specificity phosphatase 1 / P28562* / P28563* / Dual specificity protein phosphatase 1 *	ENSDARG00000100515	58
dusp5 / dual specificity phosphatase 5 / Q16690*	ENSDARG00000019307	43
dusp2 / dual specificity phosphatase 2 / Q05923*	ENSDARG00000098108	42
dusp8a / dual specificity phosphatase 8a / DUSP8* / Q13202* / O09112* / dual specificity phosphatase 8* / Dual specificity protein phosphatase 8 *	ENSDARG00000009299	33
dusp16 / dual specificity phosphatase 16 / Q9BY84*	ENSDARG00000102474	31
dusp7 / dual specificity phosphatase 7 / Q16829*	ENSDARG00000101413	31
dusp6 / dual specificity phosphatase 6 / Q16828* / Q9DBB1* / Dual specificity protein phosphatase 6 *	ENSDARG00000070914	30
dusp10 / dual specificity phosphatase 10 / Q9ESS0* / Q9Y6W6* / Dual specificity protein phosphatase 10 *	ENSDARG00000052465	28
ssh2b / slingshot protein phosphatase 2b / SSH2* / Q5SW75* / Q76I76* / slingshot protein phosphatase 2* / Protein phosphatase Slingshot homolog 2 *	ENSDARG00000098955	24
si:dkey-175m17.7	ENSDARG00000078317	24
ssh2a / slingshot protein phosphatase 2a / SSH2* / Q5SW75* / Q76I76* / slingshot protein phosphatase 2* / Protein phosphatase Slingshot homolog 2 *	ENSDARG00000088440	23
ssh1a / slingshot protein phosphatase 1a / SSH1* / Q76I79* / Q8WYL5* / slingshot protein phosphatase 1* / Protein phosphatase Slingshot homolog 1 *	ENSDARG00000056780	21
si:ch211-203d1.3 / SSH3* / Q8TE77* / Q8K330* / slingshot protein phosphatase 3* / Mus musculus slingshot protein phosphatase 3 (Ssh3), transcript variant 2, mRNA.*	ENSDARG00000079591	21
ssh1b / slingshot protein phosphatase 1b / SSH1* / Q76I79* / Q8WYL5* / slingshot protein phosphatase 1* / Protein phosphatase Slingshot homolog 1 *	ENSDARG00000010031	19
si:ch211-195b15.8	ENSDARG00000094836	18

Protein motifs (from Interpro)

Interpro ID	Name
IPR000340	Dual specificity phosphatase, catalytic domain
IPR000387	Tyrosine specific protein phosphatases domain
IPR001763	Rhodanese-like domain
IPR003595	Protein-tyrosine phosphatase, catalytic
IPR008343	Mitogen-activated protein (MAP) kinase phosphatase
IPR016130	Protein-tyrosine phosphatase, active site
IPR020422	Dual specificity protein phosphatase domain
IPR024950	Dual specificity phosphatase
IPR029021	Protein-tyrosine phosphatase-like

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000188	inactivation of MAPK activity	IEA
biological_process	GO:0001706	endoderm formation	IMP
biological_process	GO:0001714	endodermal cell fate specification	IMP
biological_process	GO:0006470	protein dephosphorylation	IEA
biological_process	GO:0016311	dephosphorylation	IEA
biological_process	GO:0035335	peptidyl-tyrosine dephosphorylation	IEA
molecular_function	GO:0004721	phosphoprotein phosphatase activity	IEA
molecular_function	GO:0004725	protein tyrosine phosphatase activity	IEA
molecular_function	GO:0008138	protein tyrosine/serine/threonine phosphatase activity	IEA
molecular_function	GO:0016787	hydrolase activity	IEA
molecular_function	GO:0016791	phosphatase activity	IEA
molecular_function	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	IEA

Pathways (from Reactome)

Pathway description

RAF-independent MAPK1/3 activation

ERKs are inactivated

Negative regulation of MAPK pathway

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
ZFA:0000017	endoderm	endoderm morphology , abnormal	Show
ZFA:0000112	gut	gut morphology , abnormal	Show
ZFA:0001094	whole organism	whole organism decreased length , abnormal	Show
ZFA:0001114	head	head decreased size , abnormal head necrotic , abnormal	Show
ZFA:0001390	pancreatic bud	pancreatic bud morphology , abnormal	Show

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSDARG00000023110	mapk7 / mitogen-activated protein kinase 7 / Q13164* / Q9WVS8*	/ reaction
ENSDARG00000070573	mapk3 / mitogen-activated protein kinase 3 / P27361* / Q63844*	/ reaction
ENSDARG00000027552	mapk1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*	/ reaction

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr