ENSG00000105053


Homo sapiens

Features
Gene ID: ENSG00000105053
  
Biological name :VRK3
  
Synonyms : Q8IV63 / vaccinia related kinase 3 / VRK3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: q13.33
Gene start: 49976467
Gene end: 50025946
  
Corresponding Affymetrix probe sets: 1566700_at (Human Genome U133 Plus 2.0 Array)   1566701_at (Human Genome U133 Plus 2.0 Array)   218022_at (Human Genome U133 Plus 2.0 Array)   221998_s_at (Human Genome U133 Plus 2.0 Array)   221999_at (Human Genome U133 Plus 2.0 Array)   239190_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000473171
Ensembl peptide - ENSP00000473222
Ensembl peptide - ENSP00000324636
Ensembl peptide - ENSP00000366210
Ensembl peptide - ENSP00000468979
Ensembl peptide - ENSP00000469092
Ensembl peptide - ENSP00000469325
Ensembl peptide - ENSP00000469400
Ensembl peptide - ENSP00000469710
Ensembl peptide - ENSP00000469802
Ensembl peptide - ENSP00000469880
Ensembl peptide - ENSP00000470156
Ensembl peptide - ENSP00000470359
Ensembl peptide - ENSP00000470940
Ensembl peptide - ENSP00000471061
Ensembl peptide - ENSP00000471661
Ensembl peptide - ENSP00000472217
Ensembl peptide - ENSP00000472541
NCBI entrez gene - 51231     See in Manteia.
RefSeq - NM_001308420
RefSeq - NM_001025778
RefSeq - NM_016440
RefSeq - XM_005258971
RefSeq - XM_005258972
RefSeq - XM_006723237
RefSeq - XM_006723238
RefSeq - XM_011527023
RefSeq Peptide - NP_001020949
RefSeq Peptide - NP_001295349
RefSeq Peptide - NP_057524
swissprot - M0R3H2
swissprot - A0A024QZI4
swissprot - Q8IV63
swissprot - M0QX88
swissprot - M0QXD7
swissprot - M0QXV1
swissprot - M0QYA8
swissprot - M0QYG0
swissprot - M0QZ79
swissprot - M0R073
swissprot - M0R025
swissprot - M0R164
swissprot - M0R200
Ensembl - ENSG00000105053
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vrk3ENSDARG00000036056Danio rerio
 ENSGALG00000035029Gallus gallus
 Vrk3ENSMUSG00000002205Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
VRK1 / Q99986 / vaccinia related kinase 1ENSG0000010074925
VRK2 / Q86Y07 / vaccinia related kinase 2ENSG0000002811624
P78368 / CSNK1G2 / casein kinase 1 gamma 2ENSG0000013327517
Q9Y6M4 / CSNK1G3 / casein kinase 1 gamma 3ENSG0000015129216
Q9HCP0 / CSNK1G1 / casein kinase 1 gamma 1ENSG0000016911816


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR026870  Zinc-ribbon domain
 IPR029038  Methionyl-tRNA synthetase, Zn-domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0008360 regulation of cell shape IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0032516 positive regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0019903 protein phosphatase binding IDA


Pathways (from Reactome)
Pathway description
ERKs are inactivated


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000108861 DUSP3 / P51452 / dual specificity phosphatase 3  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr