ENSMUSG00000002205


Mus musculus

Features
Gene ID: ENSMUSG00000002205
  
Biological name :Vrk3
  
Synonyms : Q8K3G5 / vaccinia related kinase 3 / Vrk3
  
Possible biological names infered from orthology : Q8IV63
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B3
Gene start: 44748413
Gene end: 44777515
  
Corresponding Affymetrix probe sets: 10552725 (MoGene1.0st)   1418121_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000002275
Ensembl peptide - ENSMUSP00000132748
Ensembl peptide - ENSMUSP00000131704
Ensembl peptide - ENSMUSP00000130331
Ensembl peptide - ENSMUSP00000122114
Ensembl peptide - ENSMUSP00000119073
NCBI entrez gene - 101568     See in Manteia.
MGI - MGI:2182465
RefSeq - XM_006540538
RefSeq - NM_133945
RefSeq Peptide - NP_598706
swissprot - D3Z188
swissprot - E9PY18
swissprot - E9Q754
swissprot - Q3TAR6
swissprot - Q8K3G5
swissprot - D3Z2U5
swissprot - E9PW85
Ensembl - ENSMUSG00000002205
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vrk3ENSDARG00000036056Danio rerio
 ENSGALG00000035029Gallus gallus
 VRK3ENSG00000105053Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Vrk2 / Q8BN21 / vaccinia related kinase 2 / Q86Y07*ENSMUSG0000006409028
Vrk1 / Q80X41 / vaccinia related kinase 1 / Q99986*ENSMUSG0000002111528
Q8C4X2 / Csnk1g3 / Casein kinase I isoform gamma-3 / Q9Y6M4* / casein kinase 1 gamma 3*ENSMUSG0000007356318
Q8BVP5 / Csnk1g2 / Casein kinase I isoform gamma-2 / P78368* / casein kinase 1 gamma 2*ENSMUSG0000000334518
Q8BTH8 / Csnk1g1 / Casein kinase I isoform gamma-1 / Q9HCP0* / casein kinase 1 gamma 1*ENSMUSG0000003238417


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR026870  Zinc-ribbon domain
 IPR029038  Methionyl-tRNA synthetase, Zn-domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0008360 regulation of cell shape IBA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0032516 positive regulation of phosphoprotein phosphatase activity IPI
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA


Pathways (from Reactome)
Pathway description
ERKs are inactivated


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Med28tm1.1Vra/Med28+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Med28tm1.1Vra/Med28+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001384 abnormal pup retrieval "a mother does not retrieve stray pups to the nest or delays retrieving stray pups" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Med28tm1.1Vra/Med28+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Med28tm1.1Vra/Med28+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001441 increased grooming behavior "increased amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Med28tm1.1Vra/Med28+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001447 abnormal nest building behavior "deviation from the usual behavior of mice to build sleeping nests out of any available materials; also of female mice to bulid nests to protect offspring" [J:42758, What s wrong with my mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Med28tm1.1Vra/Med28+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002065 abnormal fear/anxiety-related behavior "altered response in tests for fear or anxiety related behaviors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Med28tm1.1Vra/Med28+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002557 abnormal social/conspecific interaction "deviation of the normal behavior of mice towards each other" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Med28tm1.1Vra/Med28+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002885 abnormal AMPA-mediated synaptic currents "change in the measured amplitude or duration of response to stimulation of AMPA receptors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Med28tm1.1Vra/Med28+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003461 abnormal response to novel object "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Med28tm1.1Vra/Med28+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004000 impaired passive avoidance behavior "decrease in or absence of the latency of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Med28tm1.1Vra/Med28+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008432 abnormal long-term spatial reference memory "anomaly in long-term memory for spatial location information that is consolidated over hours and days after training or an encounter at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Med28tm1.1Vra/Med28+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0020338 abnormal hippocampal pyramidal neuron dendrite morphology "structural anomaly of the highly branched tree-like process of the hippocampal neurons that have a pyramid-shaped soma with the apex and an apical dendrite pointed toward the pial surface and other dendrites and an axon emerging from the base" [CL_1001571, ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Med28tm1.1Vra/Med28+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0020395 abnormal response to social novelty "any anomaly in the interaction of an individual with a familiar versus a novel individual of the same species; in mouse the typical behavior is is for increased interaction with the novel individual" [PMID:23280234]
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Allelic Composition: Med28tm1.1Vra/Med28+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0020508 decreased dendritic spine density "decrease in the number of dendritic spines in a given cross-sectional area of a dendrite" [MGI:smb]
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Allelic Composition: Med28tm1.1Vra/Med28+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0020510 increased dendritic spine length "increase in the distance from the base to head of a dendritic spine" [MGI:smb]
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Allelic Composition: Med28tm1.1Vra/Med28+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0020551 abnormal postsynaptic density morphology "any structural anomaly of the electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymetric, neuron-neuron synapse" [GO:0014069]
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Allelic Composition: Med28tm1.1Vra/Med28+
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003518 Dusp3 / Q9D7X3 / Dual specificity protein phosphatase 3 / P51452* / dual specificity phosphatase 3*  / complex






 

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