ENSMUSG00000021115


Mus musculus

Features
Gene ID: ENSMUSG00000021115
  
Biological name :Vrk1
  
Synonyms : Q80X41 / vaccinia related kinase 1 / Vrk1
  
Possible biological names infered from orthology : Q99986
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: E
Gene start: 106010228
Gene end: 106077426
  
Corresponding Affymetrix probe sets: 10398173 (MoGene1.0st)   1425006_a_at (Mouse Genome 430 2.0 Array)   1458951_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152249
Ensembl peptide - ENSMUSP00000152109
Ensembl peptide - ENSMUSP00000152721
Ensembl peptide - ENSMUSP00000021539
Ensembl peptide - ENSMUSP00000071922
Ensembl peptide - ENSMUSP00000082101
NCBI entrez gene - 22367     See in Manteia.
MGI - MGI:1261847
RefSeq - XM_017315047
RefSeq - XM_006515810
RefSeq - XM_006515811
RefSeq - XM_006515812
RefSeq - XM_011244103
RefSeq - XM_011244104
RefSeq - XM_017315045
RefSeq - XM_017315046
RefSeq - NM_001029843
RefSeq - NM_001029844
RefSeq - NM_011705
RefSeq - XM_006515809
RefSeq Peptide - NP_001025014
RefSeq Peptide - NP_001025015
RefSeq Peptide - NP_035835
swissprot - A0A1Y7VMH3
swissprot - A0A1Y7VLL5
swissprot - Q3UWH3
swissprot - Q80X41
Ensembl - ENSMUSG00000021115
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vrk1ENSDARG00000018006Danio rerio
 VRK1ENSGALG00000011116Gallus gallus
 VRK1ENSG00000100749Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Vrk2 / Q8BN21 / vaccinia related kinase 2 / Q86Y07*ENSMUSG0000006409044
Vrk3 / Q8K3G5 / vaccinia related kinase 3 / Q8IV63*ENSMUSG0000000220529
Q8C4X2 / Csnk1g3 / Casein kinase I isoform gamma-3 / Q9Y6M4* / casein kinase 1 gamma 3*ENSMUSG0000007356323
Q8BVP5 / Csnk1g2 / Casein kinase I isoform gamma-2 / P78368* / casein kinase 1 gamma 2*ENSMUSG0000000334522
Q8BTH8 / Csnk1g1 / Casein kinase I isoform gamma-1 / Q9HCP0* / casein kinase 1 gamma 1*ENSMUSG0000003238422


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation ISO
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008360 regulation of cell shape IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0043987 histone H3-S10 phosphorylation IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0072355 histone H3-T3 phosphorylation IEA
 biological_processGO:0090166 Golgi disassembly IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005795 Golgi stack IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity ISO
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0031493 nucleosomal histone binding IEA
 molecular_functionGO:0035175 histone kinase activity (H3-S10 specific) IEA
 molecular_functionGO:0072354 histone kinase activity (H3-T3 specific) IEA


Pathways (from Reactome)
Pathway description
Initiation of Nuclear Envelope Reformation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Klf5tm1Rng/Klf5+
Genetic Background: involves: 129/Sv

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Klf5tm1Rng/Klf5+
Genetic Background: involves: 129/Sv

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Klf5tm1Rng/Klf5+
Genetic Background: involves: 129/Sv

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Klf5tm1Rng/Klf5+
Genetic Background: involves: 129/Sv

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Klf5tm1Rng/Klf5+
Genetic Background: involves: 129/Sv

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Klf5tm1Rng/Klf5+
Genetic Background: involves: 129/Sv

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Klf5tm1Rng/Klf5+
Genetic Background: involves: 129/Sv

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Klf5tm1Rng/Klf5+
Genetic Background: involves: 129/Sv

 MP:0002685 abnormal proliferation of spermatogonia "reduction in the proliferation of the spermatogonial stem cells either due to reduced mitosis or increased apoptosis" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:62271]
Show

Allelic Composition: Klf5tm1Rng/Klf5+
Genetic Background: involves: 129/Sv

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Klf5tm1Rng/Klf5+
Genetic Background: involves: 129/Sv

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Klf5tm1Rng/Klf5+
Genetic Background: involves: 129/Sv

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Klf5tm1Rng/Klf5+
Genetic Background: involves: 129/Sv

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Klf5tm1Rng/Klf5+
Genetic Background: involves: 129/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029501 Ankle2 / Q6P1H6 / Ankyrin repeat and LEM domain-containing protein 2 / Q86XL3* / ankyrin repeat and LEM domain containing 2*  / complex / reaction






 

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