ENSMUSG00000053205


Mus musculus

Features
Gene ID: ENSMUSG00000053205
  
Biological name :Styx
  
Synonyms : Q60969 / serine/threonine/tyrosine interaction protein / Styx
  
Possible biological names infered from orthology : Q8WUJ0 / serine/threonine/tyrosine interacting protein
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: C1
Gene start: 45351093
Gene end: 45422820
  
Corresponding Affymetrix probe sets: 10414305 (MoGene1.0st)   10556133 (MoGene1.0st)   10599925 (MoGene1.0st)   1421664_a_at (Mouse Genome 430 2.0 Array)   1429710_at (Mouse Genome 430 2.0 Array)   1429711_at (Mouse Genome 430 2.0 Array)   1431048_at (Mouse Genome 430 2.0 Array)   1457807_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000154662
Ensembl peptide - ENSMUSP00000107466
Ensembl peptide - ENSMUSP00000153854
Ensembl peptide - ENSMUSP00000154148
Ensembl peptide - ENSMUSP00000154228
Ensembl peptide - ENSMUSP00000154323
Ensembl peptide - ENSMUSP00000154485
NCBI entrez gene - 56291     See in Manteia.
MGI - MGI:1891150
RefSeq - NM_019637
RefSeq Peptide - NP_062611
swissprot - Q5U4H6
swissprot - Q60969
Ensembl - ENSMUSG00000053205
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 styxENSDARG00000057699Danio rerio
 STYXENSG00000198252Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q60969 / Gm14698 / predicted gene 14698 / STYX* / Q8WUJ0* / serine/threonine/tyrosine interacting protein*ENSMUSG00000071748100
Dusp27 / Q148W8 / Inactive dual specificity phosphatase 27 / Q5VZP5* / dual specificity phosphatase 27, atypical*ENSMUSG0000002656427
Dusp19 / dual specificity phosphatase 19 / Q8WTR2*ENSMUSG0000002700126
Dusp14 / Q9JLY7 / Dual specificity protein phosphatase 14 / O95147* / dual specificity phosphatase 14*ENSMUSG0000001864826
Dusp12 / Q9D0T2 / Mus musculus dual specificity phosphatase 12 (Dusp12), transcript variant 3, mRNA. / Q9UNI6* / dual specificity phosphatase 12*ENSMUSG0000002665925
Dusp15 / Q8R4V2 / Dual specificity protein phosphatase 15 / Q9H1R2* / dual specificity phosphatase 15*ENSMUSG0000004266224
Dusp22 / Q99N11 / Dual specificity protein phosphatase 22 / Q9NRW4* / dual specificity phosphatase 22*ENSMUSG0000006925523
Dupd1 / Q8BK84 / Dual specificity phosphatase DUPD1 / Q68J44* / dual specificity phosphatase and pro isomerase domain containing 1*ENSMUSG0000006382122
Dusp18 / Q8VE01 / Dual specificity protein phosphatase 18 / Q8NEJ0* / dual specificity phosphatase 18*ENSMUSG0000004720522
Q9QYJ7 / Dusp13 / Q6B8I0 / Dual specificity protein phosphatase 13 isoform A / Q9UII6* / Q6B8I1* / dual specificity phosphatase 13*ENSMUSG0000002176822
Dusp26 / Q9D700 / Mus musculus dual specificity phosphatase 26 (putative) (Dusp26), transcript variant 2, mRNA. / Q9BV47* / dual specificity phosphatase 26*ENSMUSG0000003966122
Dusp21 / Q9D9D8 / Dual specificity phosphatase 21 / Q9H596*ENSMUSG0000002504321
Dusp3 / Q9D7X3 / Dual specificity protein phosphatase 3 / P51452* / dual specificity phosphatase 3*ENSMUSG0000000351821
Dusp28 / Q8BTR5 / Dual specificity phosphatase 28 / Q4G0W2*ENSMUSG0000004706720


Protein motifs (from Interpro)
Interpro ID Name
 IPR000340  Dual specificity phosphatase, catalytic domain
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR020422  Dual specificity protein phosphatase domain
 IPR024950  Dual specificity phosphatase
 IPR029021  Protein-tyrosine phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0045204 MAPK export from nucleus ISO
 biological_processGO:0070372 regulation of ERK1 and ERK2 cascade ISS
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Fbxl3Ovtm/Fbxl3+
Genetic Background: BTBR T+ Itpr3tf/Itpr3tf-Fbxl3Ovtm/Nwu

Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Fbxl3Ovtm/Fbxl3+
Genetic Background: BTBR T+ Itpr3tf/Itpr3tf-Fbxl3Ovtm/Nwu

Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0002208 abnormal germ cell morphology "anomalous structure of the germ cell, that is, any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fbxl3Ovtm/Fbxl3+
Genetic Background: BTBR T+ Itpr3tf/Itpr3tf-Fbxl3Ovtm/Nwu

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fbxl3Ovtm/Fbxl3+
Genetic Background: BTBR T+ Itpr3tf/Itpr3tf-Fbxl3Ovtm/Nwu

Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0002686 globozoospermia "malformation of the acrosome resulting in a round sperm head" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Fbxl3Ovtm/Fbxl3+
Genetic Background: BTBR T+ Itpr3tf/Itpr3tf-Fbxl3Ovtm/Nwu

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fbxl3Ovtm/Fbxl3+
Genetic Background: BTBR T+ Itpr3tf/Itpr3tf-Fbxl3Ovtm/Nwu

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fbxl3Ovtm/Fbxl3+
Genetic Background: BTBR T+ Itpr3tf/Itpr3tf-Fbxl3Ovtm/Nwu

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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