ENSMUSG00000039661


Mus musculus

Features
Gene ID: ENSMUSG00000039661
  
Biological name :Dusp26
  
Synonyms : Dusp26 / Mus musculus dual specificity phosphatase 26 (putative) (Dusp26), transcript variant 2, mRNA. / Q9D700
  
Possible biological names infered from orthology : dual specificity phosphatase 26 / Q9BV47
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: A3
Gene start: 31089471
Gene end: 31097047
  
Corresponding Affymetrix probe sets: 10571207 (MoGene1.0st)   1425848_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000046794
Ensembl peptide - ENSMUSP00000124949
Ensembl peptide - ENSMUSP00000126397
NCBI entrez gene - 66959     See in Manteia.
MGI - MGI:1914209
RefSeq - XM_017312942
RefSeq - NM_001357223
RefSeq - NM_025869
RefSeq Peptide - NP_080145
RefSeq Peptide - NP_001344152
swissprot - Q9D700
Ensembl - ENSMUSG00000039661
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DUSP26ENSDARG00000103752Danio rerio
 DUSP26ENSGALG00000001633Gallus gallus
 DUSP26ENSG00000133878Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dupd1 / Q8BK84 / Dual specificity phosphatase DUPD1 / Q68J44* / dual specificity phosphatase and pro isomerase domain containing 1*ENSMUSG0000006382143
Q9QYJ7 / Dusp13 / Q6B8I0 / Dual specificity protein phosphatase 13 isoform A / Q9UII6* / Q6B8I1* / dual specificity phosphatase 13*ENSMUSG0000002176840
Dusp27 / Q148W8 / Inactive dual specificity phosphatase 27 / Q5VZP5* / dual specificity phosphatase 27, atypical*ENSMUSG0000002656437
Dusp3 / Q9D7X3 / Dual specificity protein phosphatase 3 / P51452* / dual specificity phosphatase 3*ENSMUSG0000000351834
Dusp14 / Q9JLY7 / Dual specificity protein phosphatase 14 / O95147* / dual specificity phosphatase 14*ENSMUSG0000001864829
Dusp18 / Q8VE01 / Dual specificity protein phosphatase 18 / Q8NEJ0* / dual specificity phosphatase 18*ENSMUSG0000004720528
Dusp21 / Q9D9D8 / Dual specificity phosphatase 21 / Q9H596*ENSMUSG0000002504325
Dusp22 / Q99N11 / Dual specificity protein phosphatase 22 / Q9NRW4* / dual specificity phosphatase 22*ENSMUSG0000006925524
Dusp15 / Q8R4V2 / Dual specificity protein phosphatase 15 / Q9H1R2* / dual specificity phosphatase 15*ENSMUSG0000004266224
Dusp19 / dual specificity phosphatase 19 / Q8WTR2*ENSMUSG0000002700124
Dusp12 / Q9D0T2 / Mus musculus dual specificity phosphatase 12 (Dusp12), transcript variant 3, mRNA. / Q9UNI6* / dual specificity phosphatase 12*ENSMUSG0000002665924
Q60969 / Gm14698 / predicted gene 14698 / STYX* / Q8WUJ0* / serine/threonine/tyrosine interacting protein*ENSMUSG0000007174823
Styx / Q60969 / serine/threonine/tyrosine interaction protein / Q8WUJ0* / serine/threonine/tyrosine interacting protein*ENSMUSG0000005320523
Dusp28 / Q8BTR5 / Dual specificity phosphatase 28 / Q4G0W2*ENSMUSG0000004706722


Protein motifs (from Interpro)
Interpro ID Name
 IPR000340  Dual specificity phosphatase, catalytic domain
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR020405  Atypical dual specificity phosphatase, subfamily A
 IPR020417  Atypical dual specificity phosphatase
 IPR020422  Dual specificity protein phosphatase domain
 IPR024950  Dual specificity phosphatase
 IPR029021  Protein-tyrosine phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0006470 protein dephosphorylation ISO
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation ISO
 biological_processGO:0045785 positive regulation of cell adhesion ISO
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade ISO
 biological_processGO:1902310 positive regulation of peptidyl-serine dephosphorylation ISO
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005794 Golgi apparatus ISO
 molecular_functionGO:0001102 RNA polymerase II activating transcription factor binding ISO
 molecular_functionGO:0002039 p53 binding ISO
 molecular_functionGO:0004647 phosphoserine phosphatase activity ISO
 molecular_functionGO:0004721 phosphoprotein phosphatase activity ISO
 molecular_functionGO:0004725 protein tyrosine phosphatase activity ISO
 molecular_functionGO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dusp1tm1(KOMP)Wtsi/Dusp1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dusp1tm1(KOMP)Wtsi/Wtsi

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Dusp1tm1(KOMP)Wtsi/Dusp1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dusp1tm1(KOMP)Wtsi/Wtsi

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Dusp1tm1(KOMP)Wtsi/Dusp1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dusp1tm1(KOMP)Wtsi/Wtsi

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Dusp1tm1(KOMP)Wtsi/Dusp1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dusp1tm1(KOMP)Wtsi/Wtsi

 MP:0005567 decreased circulating total protein level "less than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
Show

Allelic Composition: Dusp1tm1(KOMP)Wtsi/Dusp1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dusp1tm1(KOMP)Wtsi/Wtsi

 MP:0010093 decreased circulating magnesium level "a reduction in the blood concentration of magnesium" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Dusp1tm1(KOMP)Wtsi/Dusp1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dusp1tm1(KOMP)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr