ENSG00000068971


Homo sapiens

Features
Gene ID: ENSG00000068971
  
Biological name :PPP2R5B
  
Synonyms : PPP2R5B / protein phosphatase 2 regulatory subunit Bbeta / Q15173
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q13.1
Gene start: 64917553
Gene end: 64934473
  
Corresponding Affymetrix probe sets: 204611_s_at (Human Genome U133 Plus 2.0 Array)   635_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000164133
Ensembl peptide - ENSP00000437088
Ensembl peptide - ENSP00000436136
NCBI entrez gene - 5526     See in Manteia.
OMIM - 601644
RefSeq - XM_011545132
RefSeq - XM_011545134
RefSeq - XM_011545133
RefSeq - NM_006244
RefSeq Peptide - NP_006235
swissprot - Q15173
swissprot - E9PQN5
swissprot - A0A024R593
swissprot - E9PNY3
Ensembl - ENSG00000068971
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppp2r5bENSDARG00000054931Danio rerio
 Q6PD28ENSMUSG00000024777Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q15172 / PPP2R5A / protein phosphatase 2 regulatory subunit BalphaENSG0000006602768
Q16537 / PPP2R5E / protein phosphatase 2 regulatory subunit BepsilonENSG0000015400168
Q14738 / PPP2R5D / protein phosphatase 2 regulatory subunit BdeltaENSG0000011264064
Q13362 / PPP2R5C / protein phosphatase 2 regulatory subunit BgammaENSG0000007830461


Protein motifs (from Interpro)
Interpro ID Name
 IPR002554  Protein phosphatase 2A, regulatory B subunit, B56
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001932 regulation of protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0014066 regulation of phosphatidylinositol 3-kinase signaling TAS
 biological_processGO:0031334 positive regulation of protein complex assembly IEA
 biological_processGO:0031952 regulation of protein autophosphorylation IEA
 biological_processGO:0036498 IRE1-mediated unfolded protein response TAS
 biological_processGO:0043666 regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0050730 regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway IEA
 biological_processGO:0051898 negative regulation of protein kinase B signaling TAS
 biological_processGO:0070317 negative regulation of G0 to G1 transition IEA
 biological_processGO:0071158 positive regulation of cell cycle arrest IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 cellular_componentGO:0000159 protein phosphatase type 2A complex IEA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019888 protein phosphatase regulator activity IEA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
XBP1(S) activates chaperone genes
CTLA4 inhibitory signaling
Platelet sensitization by LDL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Misspliced GSK3beta mutants stabilize beta-catenin
S33 mutants of beta-catenin arent phosphorylated
S37 mutants of beta-catenin arent phosphorylated
S45 mutants of beta-catenin arent phosphorylated
T41 mutants of beta-catenin arent phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000142208 AKT1 / P31749 / AKT serine/threonine kinase 1  / reaction
 ENSG00000100030 MAPK1 / P28482 / mitogen-activated protein kinase 1  / reaction / complex
 ENSG00000137331 IER3 / P46695 / immediate early response 3  / reaction / complex
 ENSG00000102882 MAPK3 / P27361 / mitogen-activated protein kinase 3  / complex / reaction






 

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