ENSG00000154001


Homo sapiens

Features
Gene ID: ENSG00000154001
  
Biological name :PPP2R5E
  
Synonyms : PPP2R5E / protein phosphatase 2 regulatory subunit Bepsilon / Q16537
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q23.2
Gene start: 63371357
Gene end: 63543374
  
Corresponding Affymetrix probe sets: 203338_at (Human Genome U133 Plus 2.0 Array)   227630_at (Human Genome U133 Plus 2.0 Array)   228070_at (Human Genome U133 Plus 2.0 Array)   229322_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000337641
Ensembl peptide - ENSP00000404632
Ensembl peptide - ENSP00000452396
NCBI entrez gene - 5529     See in Manteia.
OMIM - 601647
RefSeq - NM_001282182
RefSeq - NM_001282179
RefSeq - NM_001282180
RefSeq - NM_001282181
RefSeq - NM_006246
RefSeq Peptide - NP_001269108
RefSeq Peptide - NP_001269109
RefSeq Peptide - NP_001269110
RefSeq Peptide - NP_001269111
RefSeq Peptide - NP_006237
swissprot - Q16537
Ensembl - ENSG00000154001
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppp2r5eaENSDARG00000015474Danio rerio
 ppp2r5ebENSDARG00000069118Danio rerio
 PPP2R5EENSGALG00000011840Gallus gallus
 Q61151ENSMUSG00000021051Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q15172 / PPP2R5A / protein phosphatase 2 regulatory subunit BalphaENSG0000006602777
Q15173 / PPP2R5B / protein phosphatase 2 regulatory subunit BbetaENSG0000006897172
Q14738 / PPP2R5D / protein phosphatase 2 regulatory subunit BdeltaENSG0000011264068
Q13362 / PPP2R5C / protein phosphatase 2 regulatory subunit BgammaENSG0000007830465


Protein motifs (from Interpro)
Interpro ID Name
 IPR002554  Protein phosphatase 2A, regulatory B subunit, B56
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0043666 regulation of phosphoprotein phosphatase activity IEA
 cellular_componentGO:0000159 protein phosphatase type 2A complex IEA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019888 protein phosphatase regulator activity TAS


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
CTLA4 inhibitory signaling
Platelet sensitization by LDL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Misspliced GSK3beta mutants stabilize beta-catenin
S33 mutants of beta-catenin arent phosphorylated
S37 mutants of beta-catenin arent phosphorylated
S45 mutants of beta-catenin arent phosphorylated
T41 mutants of beta-catenin arent phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr