ENSG00000066027


Homo sapiens

Features
Gene ID: ENSG00000066027
  
Biological name :PPP2R5A
  
Synonyms : PPP2R5A / protein phosphatase 2 regulatory subunit Balpha / Q15172
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q32.3
Gene start: 212285537
Gene end: 212361863
  
Corresponding Affymetrix probe sets: 202186_x_at (Human Genome U133 Plus 2.0 Array)   202187_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000261461
Ensembl peptide - ENSP00000442866
NCBI entrez gene - 5525     See in Manteia.
OMIM - 601643
RefSeq - NM_001199756
RefSeq - NM_006243
RefSeq Peptide - NP_001186685
RefSeq Peptide - NP_006234
swissprot - Q15172
Ensembl - ENSG00000066027
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppp2r5aENSDARG00000027017Danio rerio
 PPP2R5AENSGALG00000009828Gallus gallus
 Q6PD03ENSMUSG00000026626Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q16537 / PPP2R5E / protein phosphatase 2 regulatory subunit BepsilonENSG0000015400174
Q15173 / PPP2R5B / protein phosphatase 2 regulatory subunit BbetaENSG0000006897169
Q14738 / PPP2R5D / protein phosphatase 2 regulatory subunit BdeltaENSG0000011264064
Q13362 / PPP2R5C / protein phosphatase 2 regulatory subunit BgammaENSG0000007830463


Protein motifs (from Interpro)
Interpro ID Name
 IPR002554  Protein phosphatase 2A, regulatory B subunit, B56
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IDA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0035307 positive regulation of protein dephosphorylation IMP
 biological_processGO:0043666 regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0090219 negative regulation of lipid kinase activity IMP
 biological_processGO:1903077 negative regulation of protein localization to plasma membrane IMP
 cellular_componentGO:0000159 protein phosphatase type 2A complex IDA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0030018 Z disc IDA
 cellular_componentGO:0031430 M band ISS
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IDA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019888 protein phosphatase regulator activity TAS
 molecular_functionGO:0019900 kinase binding IPI


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
CTLA4 inhibitory signaling
Platelet sensitization by LDL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Misspliced GSK3beta mutants stabilize beta-catenin
S33 mutants of beta-catenin arent phosphorylated
S37 mutants of beta-catenin arent phosphorylated
S45 mutants of beta-catenin arent phosphorylated
T41 mutants of beta-catenin arent phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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