ENSMUSG00000032010


Mus musculus

Features
Gene ID: ENSMUSG00000032010
  
Biological name :Usp2
  
Synonyms : O88623 / ubiquitin specific peptidase 2 / Usp2
  
Possible biological names infered from orthology : O75604
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A5.1
Gene start: 44067021
Gene end: 44095627
  
Corresponding Affymetrix probe sets: 10584634 (MoGene1.0st)   1417168_a_at (Mouse Genome 430 2.0 Array)   1417169_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135859
Ensembl peptide - ENSMUSP00000034508
Ensembl peptide - ENSMUSP00000070264
Ensembl peptide - ENSMUSP00000110479
Ensembl peptide - ENSMUSP00000135018
Ensembl peptide - ENSMUSP00000135482
Ensembl peptide - ENSMUSP00000135788
NCBI entrez gene - 53376     See in Manteia.
MGI - MGI:1858178
RefSeq - XM_017313470
RefSeq - XM_017313464
RefSeq - XM_017313465
RefSeq - XM_017313466
RefSeq - XM_017313467
RefSeq - XM_017313468
RefSeq - XM_017313469
RefSeq - NM_016808
RefSeq - NM_198091
RefSeq - NM_198092
RefSeq - XM_006510480
RefSeq - XM_011242577
RefSeq - XM_017313461
RefSeq - XM_017313462
RefSeq - XM_017313463
RefSeq Peptide - NP_932760
RefSeq Peptide - NP_058088
RefSeq Peptide - NP_932759
swissprot - H3BLN9
swissprot - O88623
swissprot - H3BLH3
Ensembl - ENSMUSG00000032010
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 usp2aENSDARG00000020107Danio rerio
 usp2bENSDARG00000074120Danio rerio
 USP2ENSGALG00000006755Gallus gallus
 USP2ENSG00000036672Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Usp21 / ubiquitin specific peptidase 21 / Q9UK80*ENSMUSG0000005348337
Usp8 / Q80U87 / ubiquitin specific peptidase 8 / P40818*ENSMUSG0000002736330
Usp33 / Q8R5K2 / ubiquitin specific peptidase 33 / Q8TEY7*ENSMUSG0000002543723
Usp20 / Q8C6M1 / ubiquitin specific peptidase 20 / Q9Y2K6*ENSMUSG0000002685422
Usp45 / Q8K387 / ubiquitin specific petidase 45 / Q70EL2* / ubiquitin specific peptidase 45*ENSMUSG0000004045521
Usp50 / Q6P8X6 / ubiquitin specific peptidase 50 / Q70EL3*ENSMUSG0000002736421
Usp16 / Q99LG0 / ubiquitin specific peptidase 16 / Q9Y5T5*ENSMUSG0000002561621


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISS
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007517 muscle organ development IEA
 biological_processGO:0016579 protein deubiquitination ISO
 biological_processGO:0032922 circadian regulation of gene expression IMP
 biological_processGO:0043153 entrainment of circadian clock by photoperiod IMP
 biological_processGO:0045475 locomotor rhythm IMP
 biological_processGO:0045931 positive regulation of mitotic cell cycle ISS
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0048512 circadian behavior IMP
 biological_processGO:0050821 protein stabilization ISS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005938 cell cortex IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity ISS
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030332 cyclin binding ISO
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA
 molecular_functionGO:0042802 identical protein binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Ub-specific processing proteases
Regulation of TP53 Degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nfatc1tm1Rao/Nfatc1tm1Rao,Nfatc2tm1Rao/Nfatc2tm1Rao,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Tcf21tm3.1(cre/Esr1*)Eno/Tcf21+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Usp22tm1b(KOMP)Wtsi/Usp22tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Usp22tm1b(KOMP)Wtsi/Wtsi

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Nfatc1tm1Rao/Nfatc1tm1Rao,Nfatc2tm1Rao/Nfatc2tm1Rao,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfatc1tm1Rao/Nfatc1tm1Rao,Nfatc2tm1Rao/Nfatc2tm1Rao,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfatc1tm1Rao/Nfatc1tm1Rao,Nfatc2tm1Rao/Nfatc2tm1Rao,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Usp22tm1b(KOMP)Wtsi/Usp22tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Usp22tm1b(KOMP)Wtsi/Wtsi

 MP:0002674 abnormal sperm motility "anomalies in the mobility of the spermatozoa" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nfatc1tm1Rao/Nfatc1tm1Rao,Nfatc2tm1Rao/Nfatc2tm1Rao,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

 MP:0006362 abnormal male germ cell morphology "any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfatc1tm1Rao/Nfatc1tm1Rao,Nfatc2tm1Rao/Nfatc2tm1Rao,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

 MP:0020468 abnormal circadian behavior period "any change in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [MGI:smb]
Show

Allelic Composition: Tcf21tm3.1(cre/Esr1*)Eno/Tcf21+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0020475 delayed circadian behavior phase "decrease in the phase relationship between a temporal synchronizing event (such as light cycle) and a behavioral phase reference point of an animal (such as activity onset)" [MGI:smb]
Show

Allelic Composition: Tcf21tm3.1(cre/Esr1*)Eno/Tcf21+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Arntltm1Bra/Arntl+,Usp2tm1.1Bjc/Usp2+
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020184 Mdm2 / P23804 / E3 ubiquitin-protein ligase Mdm2 / Q00987* / MDM2 proto-oncogene*  / complex / reaction
 ENSMUSG00000054387 Mdm4 / O35618 / transformed mouse 3T3 cell double minute 4 / O15151* / MDM4, p53 regulator*  / complex / reaction






 

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