ENSMUSG00000026854


Mus musculus

Features
Gene ID: ENSMUSG00000026854
  
Biological name :Usp20
  
Synonyms : Q8C6M1 / ubiquitin specific peptidase 20 / Usp20
  
Possible biological names infered from orthology : Q9Y2K6
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: B
Gene start: 30982279
Gene end: 31023586
  
Corresponding Affymetrix probe sets: 10471080 (MoGene1.0st)   1423777_at (Mouse Genome 430 2.0 Array)   1423778_at (Mouse Genome 430 2.0 Array)   1436245_at (Mouse Genome 430 2.0 Array)   1442943_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116696
Ensembl peptide - ENSMUSP00000127388
Ensembl peptide - ENSMUSP00000121699
Ensembl peptide - ENSMUSP00000119197
Ensembl peptide - ENSMUSP00000060167
Ensembl peptide - ENSMUSP00000099913
Ensembl peptide - ENSMUSP00000115347
Ensembl peptide - ENSMUSP00000115613
NCBI entrez gene - 74270     See in Manteia.
MGI - MGI:1921520
RefSeq - XM_017319297
RefSeq - NM_028846
RefSeq - XM_017319296
RefSeq Peptide - NP_083122
swissprot - B0R093
swissprot - A2AQ35
swissprot - Q8C9A6
swissprot - A2AQ34
swissprot - F6QWP5
swissprot - Q8C6M1
Ensembl - ENSMUSG00000026854
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 usp20ENSDARG00000027501Danio rerio
 USP20ENSGALG00000041104Gallus gallus
 USP20ENSG00000136878Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Usp33 / Q8R5K2 / ubiquitin specific peptidase 33 / Q8TEY7*ENSMUSG0000002543758
Usp16 / Q99LG0 / ubiquitin specific peptidase 16 / Q9Y5T5*ENSMUSG0000002561617
Usp45 / Q8K387 / ubiquitin specific petidase 45 / Q70EL2* / ubiquitin specific peptidase 45*ENSMUSG0000004045516
Usp8 / Q80U87 / ubiquitin specific peptidase 8 / P40818*ENSMUSG0000002736316
Usp2 / O88623 / ubiquitin specific peptidase 2 / O75604*ENSMUSG0000003201015
Usp21 / ubiquitin specific peptidase 21 / Q9UK80*ENSMUSG0000005348314
Usp50 / Q6P8X6 / ubiquitin specific peptidase 50 / Q70EL3*ENSMUSG0000002736413


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR001607  Zinc finger, UBP-type
 IPR006615  Peptidase C19, ubiquitin-specific peptidase, DUSP domain
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain
 IPR035927  DUSP-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0008277 regulation of G-protein coupled receptor protein signaling pathway ISS
 biological_processGO:0016579 protein deubiquitination ISO
 biological_processGO:0070536 protein K63-linked deubiquitination ISO
 biological_processGO:0071108 protein K48-linked deubiquitination ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome ISS
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding ISO
 molecular_functionGO:0004197 cysteine-type endopeptidase activity ISS
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0008044 increased NK cell number "greater number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000045730 Adrb2 / P18762 / Beta-2 adrenergic receptor / P07550* / adrenoceptor beta 2*  / complex






 

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