ENSMUSG00000025616


Mus musculus

Features
Gene ID: ENSMUSG00000025616
  
Biological name :Usp16
  
Synonyms : Q99LG0 / ubiquitin specific peptidase 16 / Usp16
  
Possible biological names infered from orthology : Q9Y5T5
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: C3.3
Gene start: 87454703
Gene end: 87483517
  
Corresponding Affymetrix probe sets: 10436708 (MoGene1.0st)   1430203_at (Mouse Genome 430 2.0 Array)   1431951_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114058
Ensembl peptide - ENSMUSP00000122384
Ensembl peptide - ENSMUSP00000116323
Ensembl peptide - ENSMUSP00000026710
NCBI entrez gene - 74112     See in Manteia.
MGI - MGI:1921362
RefSeq - XM_006523100
RefSeq - XM_006523101
RefSeq - XM_006523102
RefSeq - XM_017317146
RefSeq - NM_024258
RefSeq Peptide - NP_077220
swissprot - Q99LG0
swissprot - D3Z6E6
swissprot - D3YVU1
swissprot - D6RHQ6
Ensembl - ENSMUSG00000025616
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 usp16ENSDARG00000060633Danio rerio
 USP16ENSGALG00000015813Gallus gallus
 USP16ENSG00000156256Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Usp45 / Q8K387 / ubiquitin specific petidase 45 / Q70EL2* / ubiquitin specific peptidase 45*ENSMUSG0000004045536
Usp33 / Q8R5K2 / ubiquitin specific peptidase 33 / Q8TEY7*ENSMUSG0000002543719
Usp20 / Q8C6M1 / ubiquitin specific peptidase 20 / Q9Y2K6*ENSMUSG0000002685419
Usp8 / Q80U87 / ubiquitin specific peptidase 8 / P40818*ENSMUSG0000002736317
Usp2 / O88623 / ubiquitin specific peptidase 2 / O75604*ENSMUSG0000003201015
Usp21 / ubiquitin specific peptidase 21 / Q9UK80*ENSMUSG0000005348314
Usp50 / Q6P8X6 / ubiquitin specific peptidase 50 / Q70EL3*ENSMUSG0000002736413


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR001607  Zinc finger, UBP-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain
 IPR030849  Ubiquitin carboxyl-terminal hydrolase 16


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0016578 histone deubiquitination ISS
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:0035522 monoubiquitinated histone H2A deubiquitination IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045901 positive regulation of translational elongation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0051289 protein homotetramerization IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0070537 histone H2A K63-linked deubiquitination IEA
 cellular_componentGO:0005634 nucleus ISO
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IEA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA
 molecular_functionGO:0042393 histone binding IEA
 molecular_functionGO:0043130 ubiquitin binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0011095 complete embryonic lethality between implantation and placentation "death of all organisms of a given genotype in a population between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [MGI:csmith]
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Allelic Composition: Hsp90aa1Tg(Tyr)2396BOve/Hsp90aa1Tg(Tyr)2396BOve
Genetic Background: FVB/N-Hsp90aa1Tg(Tyr)2396BOve

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Txniptm1b(EUCOMM)Hmgu/Txniptm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Txniptm1b(EUCOMM)Hmgu/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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