ENSMUSG00000053825


Mus musculus

Features
Gene ID: ENSMUSG00000053825
  
Biological name :Ppfia2
  
Synonyms : Ppfia2 / protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
  
Possible biological names infered from orthology : O75334 / PTPRF interacting protein alpha 2
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: D1
Gene start: 106470339
Gene end: 106935952
  
Corresponding Affymetrix probe sets: 10366196 (MoGene1.0st)   1456856_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029404
Ensembl peptide - ENSMUSP00000151545
NCBI entrez gene - 327814     See in Manteia.
MGI - MGI:2443834
RefSeq - XM_017314008
RefSeq - XM_017314004
RefSeq - XM_017314005
RefSeq - XM_017314006
RefSeq - XM_017314007
RefSeq - NM_001205341
RefSeq - NM_177373
RefSeq - XM_006513775
RefSeq - XM_006513776
RefSeq - XM_006513777
RefSeq - XM_006513778
RefSeq - XM_006513780
RefSeq - XM_006513781
RefSeq - XM_006513782
RefSeq - XM_006513785
RefSeq - XM_006513786
RefSeq - XM_006513787
RefSeq - XM_006513789
RefSeq - XM_017313972
RefSeq - XM_017313973
RefSeq - XM_017313974
RefSeq - XM_017313975
RefSeq - XM_017313976
RefSeq - XM_017313977
RefSeq - XM_017313978
RefSeq - XM_017313979
RefSeq - XM_017313980
RefSeq - XM_017313981
RefSeq - XM_017313982
RefSeq - XM_017313983
RefSeq - XM_017313984
RefSeq - XM_017313985
RefSeq - XM_017313986
RefSeq - XM_017313987
RefSeq - XM_017313988
RefSeq - XM_017313989
RefSeq - XM_017313990
RefSeq - XM_017313991
RefSeq - XM_017313992
RefSeq - XM_017313993
RefSeq - XM_017313994
RefSeq - XM_017313995
RefSeq - XM_017313996
RefSeq - XM_017313997
RefSeq - XM_017313998
RefSeq - XM_017313999
RefSeq - XM_017314000
RefSeq - XM_017314001
RefSeq - XM_017314002
RefSeq - XM_017314003
RefSeq Peptide - NP_796347
RefSeq Peptide - NP_001192270
swissprot - F7CYX4
swissprot - B8QI34
Ensembl - ENSMUSG00000053825
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppfia2ENSDARG00000013000Danio rerio
 PPFIA2ENSGALG00000010958Gallus gallus
 O75334ENSG00000139220Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ppfia1 / protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 / Q13136* / PTPRF interacting protein alpha 1*ENSMUSG0000003751969
Ppfia4 / protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 / O75335* / PTPRF interacting protein alpha 4*ENSMUSG0000002645866
P60469 / Ppfia3 / protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 / O75145* / PTPRF interacting protein alpha 3*ENSMUSG0000000386359
O35711 / Ppfibp2 / PTPRF interacting protein, binding protein 2 (liprin beta 2) / Q8ND30* / PPFIA binding protein 2*ENSMUSG0000003652818
Q8C8U0 / Ppfibp1 / PTPRF interacting protein, binding protein 1 (liprin beta 1) / Q86W92* / PPFIA binding protein 1*ENSMUSG0000001648717
Kazn / Q69ZS8 / Kazrin / Q674X7* / kazrin, periplakin interacting protein*ENSMUSG000000406068


Protein motifs (from Interpro)
Interpro ID Name
 IPR001660  Sterile alpha motif domain
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR029515  LAR-interacting protein, Liprin
 IPR030441  Liprin-alpha-2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Serotonin Neurotransmitter Release Cycle
Norepinephrine Neurotransmitter Release Cycle
Glutamate Neurotransmitter Release Cycle
Dopamine Neurotransmitter Release Cycle
Acetylcholine Neurotransmitter Release Cycle
Receptor-type tyrosine-protein phosphatases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Pik3c2atm1b(EUCOMM)Hmgu/Pik3c2a+
Genetic Background: C57BL/6N-Pik3c2atm1b(EUCOMM)Hmgu/Tcp

 MP:0001410 head bobbing "compulsive up and down movement of the head" [J:17123]
Show

Allelic Composition: Pik3c2atm1b(EUCOMM)Hmgu/Pik3c2a+
Genetic Background: C57BL/6N-Pik3c2atm1b(EUCOMM)Hmgu/Tcp

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pik3c2atm1b(EUCOMM)Hmgu/Pik3c2a+
Genetic Background: C57BL/6N-Pik3c2atm1b(EUCOMM)Hmgu/Tcp

 MP:0008259 abnormal optic disc morphology "any structural anomaly of the area in the retina where all of the axons of the ganglion cells exit the retina to form the optic nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pik3c2atm1b(EUCOMM)Hmgu/Pik3c2a+
Genetic Background: C57BL/6N-Pik3c2atm1b(EUCOMM)Hmgu/Tcp

 MP:0009141 increased prepulse inhibition "increase in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pik3c2atm1b(EUCOMM)Hmgu/Pik3c2a+
Genetic Background: C57BL/6N-Pik3c2atm1b(EUCOMM)Hmgu/Tcp

 MP:0010097 abnormal retinal blood vessel morphology "any structural anomaly of the blood vessels supplying the retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pik3c2atm1b(EUCOMM)Hmgu/Pik3c2a+
Genetic Background: C57BL/6N-Pik3c2atm1b(EUCOMM)Hmgu/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028399 Ptprd / Q64487 / protein tyrosine phosphatase, receptor type, D / P23468*  / reaction / complex
 ENSMUSG00000013236 Ptprs / B0V2N1 / Receptor-type tyrosine-protein phosphatase S / Q13332* / protein tyrosine phosphatase, receptor type S*  / reaction / complex
 ENSMUSG00000033295 Ptprf / A2A8L5 / Receptor-type tyrosine-protein phosphatase F / P10586* / protein tyrosine phosphatase, receptor type F*  / reaction / complex
 ENSMUSG00000034156 Q7TNF8 / Tspoap1 / Peripheral-type benzodiazepine receptor-associated protein 1 / O95153* / TSPO associated protein 1*  / complex
 ENSMUSG00000028456 Q9Z1N9 / Unc13b / unc-13 homolog B (C. elegans) / O14795* / unc-13 homolog B*  / complex






 

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