ENSG00000139220


Homo sapiens

Features
Gene ID: ENSG00000139220
  
Biological name :PPFIA2
  
Synonyms : O75334 / PPFIA2 / PTPRF interacting protein alpha 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q21.31
Gene start: 81257975
Gene end: 81759553
  
Corresponding Affymetrix probe sets: 1558295_a_at (Human Genome U133 Plus 2.0 Array)   206973_at (Human Genome U133 Plus 2.0 Array)   232073_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000450337
Ensembl peptide - ENSP00000449821
Ensembl peptide - ENSP00000450298
Ensembl peptide - ENSP00000327416
Ensembl peptide - ENSP00000385093
Ensembl peptide - ENSP00000388373
Ensembl peptide - ENSP00000438337
Ensembl peptide - ENSP00000445532
Ensembl peptide - ENSP00000446555
Ensembl peptide - ENSP00000447189
Ensembl peptide - ENSP00000447273
Ensembl peptide - ENSP00000447792
Ensembl peptide - ENSP00000447868
Ensembl peptide - ENSP00000447918
Ensembl peptide - ENSP00000448941
Ensembl peptide - ENSP00000449338
Ensembl peptide - ENSP00000449469
Ensembl peptide - ENSP00000449524
Ensembl peptide - ENSP00000449558
NCBI entrez gene - 8499     See in Manteia.
OMIM - 603143
RefSeq - XM_017020120
RefSeq - XM_017020099
RefSeq - XM_017020100
RefSeq - XM_017020101
RefSeq - XM_017020102
RefSeq - XM_017020103
RefSeq - XM_017020104
RefSeq - XM_017020105
RefSeq - XM_017020106
RefSeq - XM_017020107
RefSeq - XM_017020108
RefSeq - XM_017020109
RefSeq - XM_017020110
RefSeq - XM_017020111
RefSeq - XM_017020112
RefSeq - XM_017020113
RefSeq - XM_017020114
RefSeq - XM_017020115
RefSeq - XM_017020116
RefSeq - XM_017020117
RefSeq - XM_017020118
RefSeq - XM_017020119
RefSeq - NM_001220473
RefSeq - NM_001220474
RefSeq - NM_001220475
RefSeq - NM_001220476
RefSeq - NM_001220477
RefSeq - NM_001220478
RefSeq - NM_001220479
RefSeq - NM_001220480
RefSeq - NM_001282536
RefSeq - NM_003625
RefSeq - XM_006719670
RefSeq - XM_011538906
RefSeq - XM_011538907
RefSeq - XM_017020079
RefSeq - XM_017020080
RefSeq - XM_017020081
RefSeq - XM_017020082
RefSeq - XM_017020083
RefSeq - XM_017020084
RefSeq - XM_017020085
RefSeq - XM_017020086
RefSeq - XM_017020087
RefSeq - XM_017020088
RefSeq - XM_017020089
RefSeq - XM_017020090
RefSeq - XM_017020091
RefSeq - XM_017020092
RefSeq - XM_017020093
RefSeq - XM_017020094
RefSeq - XM_017020095
RefSeq - XM_017020096
RefSeq - XM_017020097
RefSeq - XM_017020098
RefSeq Peptide - NP_001207403
RefSeq Peptide - NP_001207404
RefSeq Peptide - NP_001207405
RefSeq Peptide - NP_001207406
RefSeq Peptide - NP_001207407
RefSeq Peptide - NP_001207408
RefSeq Peptide - NP_001207409
RefSeq Peptide - NP_001269465
RefSeq Peptide - NP_003616
RefSeq Peptide - NP_001207402
swissprot - F8VWG6
swissprot - O75334
swissprot - F8VWR9
swissprot - F8VYK7
swissprot - F8W1Y8
swissprot - G3V200
swissprot - H0YH95
swissprot - H0YHJ4
swissprot - H0YHK3
swissprot - H0YIJ4
swissprot - F8VU88
Ensembl - ENSG00000139220
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppfia2ENSDARG00000013000Danio rerio
 PPFIA2ENSGALG00000010958Gallus gallus
 Ppfia2ENSMUSG00000053825Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PPFIA1 / Q13136 / PTPRF interacting protein alpha 1ENSG0000013162667
O75335 / PPFIA4 / PTPRF interacting protein alpha 4ENSG0000014384765
O75145 / PPFIA3 / PTPRF interacting protein alpha 3ENSG0000017738059
Q8ND30 / PPFIBP2 / PPFIA binding protein 2ENSG0000016638718
KAZN / Q674X7 / kazrin, periplakin interacting proteinENSG0000018933717
Q86W92 / PPFIBP1 / PPFIA binding protein 1ENSG0000011084117


Protein motifs (from Interpro)
Interpro ID Name
 IPR001660  Sterile alpha motif domain
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR029515  LAR-interacting protein, Liprin
 IPR030438  Liprin-alpha-1
 IPR030439  Liprin-alpha-4
 IPR030441  Liprin-alpha-2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007160 cell-matrix adhesion TAS
 biological_processGO:0007269 neurotransmitter secretion TAS
 biological_processGO:0014047 glutamate secretion TAS
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048786 presynaptic active zone TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Serotonin Neurotransmitter Release Cycle
Norepinephrine Neurotransmitter Release Cycle
Glutamate Neurotransmitter Release Cycle
Dopamine Neurotransmitter Release Cycle
Acetylcholine Neurotransmitter Release Cycle
Receptor-type tyrosine-protein phosphatases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000142949 PTPRF / P10586 / protein tyrosine phosphatase, receptor type F  / complex / reaction
 ENSG00000198722 O14795 / UNC13B / unc-13 homolog B  / complex
 ENSG00000005379 O95153 / TSPOAP1 / TSPO associated protein 1  / complex
 ENSG00000153707 PTPRD / P23468 / protein tyrosine phosphatase, receptor type D  / complex / reaction
 ENSG00000105426 PTPRS / Q13332 / protein tyrosine phosphatase, receptor type S  / reaction / complex
 ENSG00000079841 RIMS1 / Q86UR5 / regulating synaptic membrane exocytosis 1  / complex






 

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