ENSG00000198722


Homo sapiens

Features
Gene ID: ENSG00000198722
  
Biological name :UNC13B
  
Synonyms : O14795 / UNC13B / unc-13 homolog B
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: p13.3
Gene start: 35161992
Gene end: 35405338
  
Corresponding Affymetrix probe sets: 202893_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000380006
Ensembl peptide - ENSP00000490683
Ensembl peptide - ENSP00000490228
Ensembl peptide - ENSP00000489581
Ensembl peptide - ENSP00000489441
Ensembl peptide - ENSP00000484432
Ensembl peptide - ENSP00000479261
Ensembl peptide - ENSP00000367756
Ensembl peptide - ENSP00000367757
NCBI entrez gene - 10497     See in Manteia.
OMIM - 605836
RefSeq - XM_011517681
RefSeq - XM_017014191
RefSeq - XM_011517686
RefSeq - XM_011517685
RefSeq - XM_011517684
RefSeq - XM_011517683
RefSeq - NM_001330653
RefSeq - NM_006377
RefSeq - XM_017014192
RefSeq - XM_011517682
RefSeq Peptide - NP_001317582
RefSeq Peptide - NP_006368
swissprot - O14795
swissprot - B1AM27
swissprot - I6L9J0
swissprot - F8W8M9
swissprot - A0A0U1RRB5
swissprot - A0A0U1RRL2
swissprot - A0A1B0GUS7
swissprot - A0A1B0GVW8
Ensembl - ENSG00000198722
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 unc13baENSDARG00000017391Danio rerio
 unc-13 homolog BENSDARG00000099113Danio rerio
 UNC13BENSGALG00000002165Gallus gallus
 Q9Z1N9ENSMUSG00000028456Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9UPW8 / UNC13A / unc-13 homolog AENSG0000013047777
Q8NB66 / UNC13C / unc-13 homolog CENSG0000013776661


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR010439  Calcium-dependent secretion activator domain
 IPR014770  Munc13 homology 1
 IPR014772  Mammalian uncoordinated homology 13, domain 2
 IPR019558  Mammalian uncoordinated homology 13, subgroup, domain 2
 IPR027080  Protein Unc-13
 IPR035892  C2 domain superfamily
 IPR037302  Protein Unc-13, C2B domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0007268 chemical synaptic transmission IEA
 biological_processGO:0007269 neurotransmitter secretion TAS
 biological_processGO:0007528 neuromuscular junction development IEA
 biological_processGO:0010808 positive regulation of synaptic vesicle priming ISS
 biological_processGO:0014047 glutamate secretion TAS
 biological_processGO:0016079 synaptic vesicle exocytosis IBA
 biological_processGO:0016081 synaptic vesicle docking IEA
 biological_processGO:0016082 synaptic vesicle priming IEA
 biological_processGO:0031914 negative regulation of synaptic plasticity IEA
 biological_processGO:0035249 synaptic transmission, glutamatergic IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0048172 regulation of short-term neuronal synaptic plasticity IEA
 biological_processGO:0050714 positive regulation of protein secretion IDA
 biological_processGO:0060384 innervation IEA
 biological_processGO:0071333 cellular response to glucose stimulus IDA
 biological_processGO:0090382 phagosome maturation IEA
 biological_processGO:0097151 positive regulation of inhibitory postsynaptic potential ISS
 biological_processGO:0099525 presynaptic dense core vesicle exocytosis IEA
 biological_processGO:1900426 positive regulation of defense response to bacterium IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031594 neuromuscular junction IEA
 cellular_componentGO:0032009 early phagosome IEA
 cellular_componentGO:0043195 terminal bouton IBA
 cellular_componentGO:0044305 calyx of Held IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048786 presynaptic active zone TAS
 cellular_componentGO:0097470 ribbon synapse IEA
 cellular_componentGO:0098793 presynapse IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding ISS
 molecular_functionGO:0005543 phospholipid binding IEA
 molecular_functionGO:0017137 Rab GTPase binding NAS
 molecular_functionGO:0019992 diacylglycerol binding IEA
 molecular_functionGO:0030742 GTP-dependent protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Serotonin Neurotransmitter Release Cycle
Norepinephrine Neurotransmitter Release Cycle
Glutamate Neurotransmitter Release Cycle
Dopamine Neurotransmitter Release Cycle
Acetylcholine Neurotransmitter Release Cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000131626 PPFIA1 / Q13136 / PTPRF interacting protein alpha 1  / complex
 ENSG00000079841 RIMS1 / Q86UR5 / regulating synaptic membrane exocytosis 1  / complex
 ENSG00000143847 O75335 / PPFIA4 / PTPRF interacting protein alpha 4  / complex
 ENSG00000005379 O95153 / TSPOAP1 / TSPO associated protein 1  / complex
 ENSG00000177380 O75145 / PPFIA3 / PTPRF interacting protein alpha 3  / complex
 ENSG00000139220 O75334 / PPFIA2 / PTPRF interacting protein alpha 2  / complex






 

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