ENSG00000137766


Homo sapiens

Features
Gene ID: ENSG00000137766
  
Biological name :UNC13C
  
Synonyms : Q8NB66 / UNC13C / unc-13 homolog C
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q21.3
Gene start: 54012904
Gene end: 54633414
  
Corresponding Affymetrix probe sets: 1556095_at (Human Genome U133 Plus 2.0 Array)   1556096_s_at (Human Genome U133 Plus 2.0 Array)   1562074_a_at (Human Genome U133 Plus 2.0 Array)   1569969_a_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000456350
Ensembl peptide - ENSP00000260323
Ensembl peptide - ENSP00000443886
Ensembl peptide - ENSP00000453018
NCBI entrez gene - 440279     See in Manteia.
OMIM - 614568
RefSeq - XM_017022225
RefSeq - XM_017022220
RefSeq - XM_017022221
RefSeq - XM_017022222
RefSeq - XM_017022223
RefSeq - XM_017022224
RefSeq - NM_001080534
RefSeq - XM_005254394
RefSeq Peptide - NP_001074003
swissprot - H0YL13
swissprot - H3BRP8
swissprot - A0A0C4DGH4
swissprot - Q8NB66
Ensembl - ENSG00000137766
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01117752.1ENSDARG00000115552Danio rerio
 UNC13CENSGALG00000035935Gallus gallus
 Q8K0T7ENSMUSG00000062151Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9UPW8 / UNC13A / unc-13 homolog AENSG0000013047746
O14795 / UNC13B / unc-13 homolog BENSG0000019872245


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR010439  Calcium-dependent secretion activator domain
 IPR014770  Munc13 homology 1
 IPR014772  Mammalian uncoordinated homology 13, domain 2
 IPR019558  Mammalian uncoordinated homology 13, subgroup, domain 2
 IPR027080  Protein Unc-13
 IPR027087  Protein Unc-13 homologue C
 IPR035892  C2 domain superfamily
 IPR037302  Protein Unc-13, C2B domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0007268 chemical synaptic transmission IEA
 biological_processGO:0016079 synaptic vesicle exocytosis IBA
 biological_processGO:0031914 negative regulation of synaptic plasticity IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0042734 presynaptic membrane IEA
 cellular_componentGO:0043195 terminal bouton IBA
 cellular_componentGO:0044305 calyx of Held IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048786 presynaptic active zone TAS
 cellular_componentGO:0098793 presynapse IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005543 phospholipid binding IEA
 molecular_functionGO:0019992 diacylglycerol binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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