ENSMUSG00000062151


Mus musculus

Features
Gene ID: ENSMUSG00000062151
  
Biological name :Unc13c
  
Synonyms : Q8K0T7 / Unc13c / unc-13 homolog C (C. elegans)
  
Possible biological names infered from orthology : Q8NB66 / unc-13 homolog C
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: D
Gene start: 73479422
Gene end: 73968966
  
Corresponding Affymetrix probe sets: 10594948 (MoGene1.0st)   10594963 (MoGene1.0st)   10594965 (MoGene1.0st)   10594967 (MoGene1.0st)   10594969 (MoGene1.0st)   10594971 (MoGene1.0st)   10594973 (MoGene1.0st)   1430511_at (Mouse Genome 430 2.0 Array)   1437319_at (Mouse Genome 430 2.0 Array)   1455304_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000074726
Ensembl peptide - ENSMUSP00000139027
NCBI entrez gene - 208898     See in Manteia.
MGI - MGI:2149021
RefSeq - XM_006510934
RefSeq - NM_001081153
RefSeq - XM_006510932
RefSeq - XM_006510933
RefSeq - XM_006510928
RefSeq - XM_006510929
RefSeq - XM_006510930
RefSeq - XM_006510931
RefSeq Peptide - NP_001074622
swissprot - Q8K0T7
Ensembl - ENSMUSG00000062151
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01117752.1ENSDARG00000115552Danio rerio
 UNC13CENSGALG00000035935Gallus gallus
 Q8NB66ENSG00000137766Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q4KUS2 / Unc13a / unc-13 homolog A (C. elegans) / Q9UPW8* / unc-13 homolog A*ENSMUSG0000003479946
Q9Z1N9 / Unc13b / unc-13 homolog B (C. elegans) / O14795* / unc-13 homolog B*ENSMUSG0000002845645


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR010439  Calcium-dependent secretion activator domain
 IPR014770  Munc13 homology 1
 IPR014772  Mammalian uncoordinated homology 13, domain 2
 IPR019558  Mammalian uncoordinated homology 13, subgroup, domain 2
 IPR027080  Protein Unc-13
 IPR027087  Protein Unc-13 homologue C
 IPR035892  C2 domain superfamily
 IPR037302  Protein Unc-13, C2B domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0007268 chemical synaptic transmission IMP
 biological_processGO:0016079 synaptic vesicle exocytosis IBA
 biological_processGO:0031914 negative regulation of synaptic plasticity IGI
 biological_processGO:0035556 intracellular signal transduction IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0042734 presynaptic membrane IEA
 cellular_componentGO:0043195 terminal bouton IBA
 cellular_componentGO:0044305 calyx of Held ISS
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048786 presynaptic active zone IBA
 cellular_componentGO:0098793 presynapse IDA
 molecular_functionGO:0001566 non-kinase phorbol ester receptor activity TAS
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005543 phospholipid binding IEA
 molecular_functionGO:0019992 diacylglycerol binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Nphs1-cre)1Seq/0
Genetic Background: involves: 129/Sv

 MP:0002804 abnormal motor learning "defects in the ability to repeat a motor task requiring well coordinated movements and balance; measures cerebellar dependent learning" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Nphs1-cre)1Seq/0
Genetic Background: involves: 129/Sv

 MP:0002919 enhanced paired-pulse facilitation "increase in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to greater increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Nphs1-cre)1Seq/0
Genetic Background: involves: 129/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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