ENSG00000143847


Homo sapiens

Features
Gene ID: ENSG00000143847
  
Biological name :PPFIA4
  
Synonyms : O75335 / PPFIA4 / PTPRF interacting protein alpha 4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q32.1
Gene start: 203026498
Gene end: 203078740
  
Corresponding Affymetrix probe sets: 214978_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000471264
Ensembl peptide - ENSP00000470427
Ensembl peptide - ENSP00000472251
Ensembl peptide - ENSP00000272198
Ensembl peptide - ENSP00000295706
Ensembl peptide - ENSP00000356209
Ensembl peptide - ENSP00000402576
NCBI entrez gene - 8497     See in Manteia.
OMIM - 603145
RefSeq - XM_017002609
RefSeq - NM_001304332
RefSeq - XM_006711586
RefSeq - XM_011510070
RefSeq - XM_017002606
RefSeq - XM_017002607
RefSeq - XM_017002608
RefSeq - NM_001304331
RefSeq Peptide - NP_001291260
RefSeq Peptide - NP_001291261
swissprot - M0QZB5
swissprot - M0R219
swissprot - O75335
swissprot - B1APN9
Ensembl - ENSG00000143847
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppfia4ENSDARG00000053205Danio rerio
 PPFIA4ENSGALG00000000217Gallus gallus
 Ppfia4ENSMUSG00000026458Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O75334 / PPFIA2 / PTPRF interacting protein alpha 2ENSG0000013922068
PPFIA1 / Q13136 / PTPRF interacting protein alpha 1ENSG0000013162664
O75145 / PPFIA3 / PTPRF interacting protein alpha 3ENSG0000017738059
KAZN / Q674X7 / kazrin, periplakin interacting proteinENSG0000018933718
Q86W92 / PPFIBP1 / PPFIA binding protein 1ENSG0000011084118
Q8ND30 / PPFIBP2 / PPFIA binding protein 2ENSG0000016638717


Protein motifs (from Interpro)
Interpro ID Name
 IPR001660  Sterile alpha motif domain
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR029515  LAR-interacting protein, Liprin
 IPR030439  Liprin-alpha-4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007269 neurotransmitter secretion TAS
 biological_processGO:0014047 glutamate secretion TAS
 cellular_componentGO:0005622 intracellular TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0045202 synapse ISS
 cellular_componentGO:0048786 presynaptic active zone TAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Serotonin Neurotransmitter Release Cycle
Norepinephrine Neurotransmitter Release Cycle
Glutamate Neurotransmitter Release Cycle
Dopamine Neurotransmitter Release Cycle
Acetylcholine Neurotransmitter Release Cycle
Receptor-type tyrosine-protein phosphatases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000005379 O95153 / TSPOAP1 / TSPO associated protein 1  / complex
 ENSG00000198722 O14795 / UNC13B / unc-13 homolog B  / complex
 ENSG00000142949 PTPRF / P10586 / protein tyrosine phosphatase, receptor type F  / reaction / complex
 ENSG00000153707 PTPRD / P23468 / protein tyrosine phosphatase, receptor type D  / reaction / complex
 ENSG00000105426 PTPRS / Q13332 / protein tyrosine phosphatase, receptor type S  / complex / reaction
 ENSG00000079841 RIMS1 / Q86UR5 / regulating synaptic membrane exocytosis 1  / complex






 

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