ENSG00000177380


Homo sapiens

Features
Gene ID: ENSG00000177380
  
Biological name :PPFIA3
  
Synonyms : O75145 / PPFIA3 / PTPRF interacting protein alpha 3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.33
Gene start: 49119389
Gene end: 49151026
  
Corresponding Affymetrix probe sets: 213368_x_at (Human Genome U133 Plus 2.0 Array)   215280_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000473621
Ensembl peptide - ENSP00000473423
Ensembl peptide - ENSP00000473622
Ensembl peptide - ENSP00000473470
Ensembl peptide - ENSP00000335614
Ensembl peptide - ENSP00000473418
NCBI entrez gene - 8541     See in Manteia.
OMIM - 603144
RefSeq - NM_003660
RefSeq - XM_017027407
RefSeq Peptide - NP_003651
swissprot - R4GN36
swissprot - R4GNF1
swissprot - O75145
swissprot - A0A0C4DGR7
swissprot - A0A0C4DGR8
Ensembl - ENSG00000177380
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppfia3ENSDARG00000077053Danio rerio
 P60469ENSMUSG00000003863Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PPFIA1 / Q13136 / PTPRF interacting protein alpha 1ENSG0000013162663
O75334 / PPFIA2 / PTPRF interacting protein alpha 2ENSG0000013922062
O75335 / PPFIA4 / PTPRF interacting protein alpha 4ENSG0000014384758
Q8ND30 / PPFIBP2 / PPFIA binding protein 2ENSG0000016638718
KAZN / Q674X7 / kazrin, periplakin interacting proteinENSG0000018933718
Q86W92 / PPFIBP1 / PPFIA binding protein 1ENSG0000011084118


Protein motifs (from Interpro)
Interpro ID Name
 IPR001660  Sterile alpha motif domain
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR029515  LAR-interacting protein, Liprin
 IPR030440  Liprin-alpha-3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007269 neurotransmitter secretion IEA
 biological_processGO:0014047 glutamate secretion TAS
 biological_processGO:0048172 regulation of short-term neuronal synaptic plasticity ISS
 cellular_componentGO:0001669 acrosomal vesicle IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0048786 presynaptic active zone IEA
 cellular_componentGO:0098875 epididymosome ISS
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Serotonin Neurotransmitter Release Cycle
Norepinephrine Neurotransmitter Release Cycle
Glutamate Neurotransmitter Release Cycle
Dopamine Neurotransmitter Release Cycle
Acetylcholine Neurotransmitter Release Cycle
Receptor-type tyrosine-protein phosphatases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000005379 O95153 / TSPOAP1 / TSPO associated protein 1  / complex
 ENSG00000198722 O14795 / UNC13B / unc-13 homolog B  / complex
 ENSG00000142949 PTPRF / P10586 / protein tyrosine phosphatase, receptor type F  / reaction / complex
 ENSG00000105426 PTPRS / Q13332 / protein tyrosine phosphatase, receptor type S  / reaction / complex
 ENSG00000153707 PTPRD / P23468 / protein tyrosine phosphatase, receptor type D  / complex / reaction
 ENSG00000079841 RIMS1 / Q86UR5 / regulating synaptic membrane exocytosis 1  / complex






 

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