ENSMUSG00000034156


Mus musculus

Features
Gene ID: ENSMUSG00000034156
  
Biological name :Tspoap1
  
Synonyms : Peripheral-type benzodiazepine receptor-associated protein 1 / Q7TNF8 / Tspoap1
  
Possible biological names infered from orthology : O95153 / TSPO associated protein 1
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: C
Gene start: 87760541
Gene end: 87785928
  
Corresponding Affymetrix probe sets: 10380137 (MoGene1.0st)   1455771_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117356
Ensembl peptide - ENSMUSP00000048063
Ensembl peptide - ENSMUSP00000098209
Ensembl peptide - ENSMUSP00000118819
Ensembl peptide - ENSMUSP00000122665
NCBI entrez gene - 207777     See in Manteia.
MGI - MGI:2450877
RefSeq - XM_006532712
RefSeq - XM_006532706
RefSeq - XM_006532707
RefSeq - XM_006532708
RefSeq - XM_006532709
RefSeq - XM_006532710
RefSeq - XM_006532711
RefSeq - NM_172449
RefSeq - XM_006532702
RefSeq - XM_006532703
RefSeq - XM_006532704
RefSeq Peptide - NP_766037
swissprot - F7CD74
swissprot - F7AUI0
swissprot - F6WV49
swissprot - Q5NCP6
swissprot - Q7TNF8
Ensembl - ENSMUSG00000034156
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-105f12.2ENSDARG00000090126Danio rerio
 TSPOAP1ENSGALG00000042533Gallus gallus
 O95153ENSG00000005379Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rimbp3 / Q3V0F0 / RIMS-binding protein 3 / A6NJZ7* / A6NNM3* / Q9UFD9* / RIMBP3C* / RIMBP3B* / RIMS binding protein 3B* / RIMS binding protein 3C*ENSMUSG0000007163625
Q80U40 / Rimbp2 / RIMS-binding protein 2 / O15034*ENSMUSG0000002942024


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR035517  RIMS-binding protein 1
 IPR035753  RIMS-binding protein, second SH3 domain
 IPR035755  RIMS-binding protein, third SH3 domain
 IPR036028  SH3-like domain superfamily
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008150 biological_process ND
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0030156 benzodiazepine receptor binding IEA


Pathways (from Reactome)
Pathway description
Serotonin Neurotransmitter Release Cycle
Norepinephrine Neurotransmitter Release Cycle
Pregnenolone biosynthesis
Glutamate Neurotransmitter Release Cycle
Dopamine Neurotransmitter Release Cycle
Acetylcholine Neurotransmitter Release Cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Insl5tm1Dgen/Insl5tm1Dgen
Genetic Background: B6.129-Insl5tm1Dgen/J

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Smn1tm1Msd/Smn1tm1Msd
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0002919 enhanced paired-pulse facilitation "increase in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to greater increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Rimbp2tm1.2Geno/Rimbp2tm1.2Geno,Tspoap1tm1.2Geno/Tspoap1tm1.2Geno
Genetic Background: involves: C57BL/6

 MP:0004807 abnormal paired pulse inhibition "defects in the supressive response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of inhibition of neurotransmitter release at the second stimulus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rimbp2tm1.2Geno/Rimbp2tm1.2Geno,Tspoap1tm1.2Geno/Tspoap1tm1.2Geno
Genetic Background: involves: C57BL/6

 MP:0004859 abnormal synaptic plasticity "anomaly in the ability of a synapse to change its strength as a result of successive activations" [MESH:National Library of Medicine_Medical Subject Headings, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rimbp2tm1.2Geno/Rimbp2tm1.2Geno,Tspoap1tm1.2Geno/Tspoap1tm1.2Geno
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003863 P60469 / Ppfia3 / protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 / O75145* / PTPRF interacting protein alpha 3*  / complex
 ENSMUSG00000053825 Ppfia2 / protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 / O75334* / PTPRF interacting protein alpha 2*  / complex
 ENSMUSG00000041736 Tspo / P50637 / Translocator protein / B1AH88* / P30536*  / complex
 ENSMUSG00000028456 Q9Z1N9 / Unc13b / unc-13 homolog B (C. elegans) / O14795* / unc-13 homolog B*  / complex
 ENSMUSG00000037519 Ppfia1 / protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 / Q13136* / PTPRF interacting protein alpha 1*  / complex
 ENSMUSG00000026458 Ppfia4 / protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 / O75335* / PTPRF interacting protein alpha 4*  / complex






 

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