ENSMUSG00000029420


Mus musculus

Features
Gene ID: ENSMUSG00000029420
  
Biological name :Rimbp2
  
Synonyms : Q80U40 / Rimbp2 / RIMS-binding protein 2
  
Possible biological names infered from orthology : O15034
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: G1.3
Gene start: 128757791
Gene end: 128953486
  
Corresponding Affymetrix probe sets: 10534021 (MoGene1.0st)   1441625_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142712
Ensembl peptide - ENSMUSP00000142455
Ensembl peptide - ENSMUSP00000143099
Ensembl peptide - ENSMUSP00000143725
Ensembl peptide - ENSMUSP00000143276
Ensembl peptide - ENSMUSP00000106978
NCBI entrez gene - 231760     See in Manteia.
MGI - MGI:2443235
RefSeq - XM_017320871
RefSeq - XM_006504293
RefSeq - XM_006504294
RefSeq - XM_006504295
RefSeq - XM_006504296
RefSeq - XM_006504297
RefSeq - XM_011240839
RefSeq - XM_017320870
RefSeq - NM_001081388
RefSeq - NM_001310733
RefSeq - XM_006504288
RefSeq - XM_006504289
RefSeq Peptide - NP_001074857
RefSeq Peptide - NP_001297662
swissprot - A0A0G2JFB0
swissprot - D3YXR8
swissprot - A0A0G2JEC0
swissprot - Q80U40
swissprot - A0A0G2JGW5
Ensembl - ENSMUSG00000029420
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rimbp2ENSDARG00000093752Danio rerio
 rimbp2ENSDARG00000001154Danio rerio
 si:ch73-287m6.1ENSDARG00000104101Danio rerio
 RIMBP2ENSGALG00000002579Gallus gallus
 O15034ENSG00000060709Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q7TNF8 / Tspoap1 / Peripheral-type benzodiazepine receptor-associated protein 1 / O95153* / TSPO associated protein 1*ENSMUSG0000003415640
Rimbp3 / Q3V0F0 / RIMS-binding protein 3 / A6NJZ7* / A6NNM3* / Q9UFD9* / RIMBP3C* / RIMBP3B* / RIMS binding protein 3B* / RIMS binding protein 3C*ENSMUSG0000007163624


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR014727  DNA topoisomerase I, catalytic core, alpha/beta subdomain
 IPR035519  RIMS-binding protein 2
 IPR035753  RIMS-binding protein, second SH3 domain
 IPR035755  RIMS-binding protein, third SH3 domain
 IPR036028  SH3-like domain superfamily
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006265 DNA topological change IEA
 biological_processGO:0010923 negative regulation of phosphatase activity IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003917 DNA topoisomerase type I activity IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Insl5tm1Dgen/Insl5tm1Dgen
Genetic Background: B6.129-Insl5tm1Dgen/J

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Smn1tm1Msd/Smn1tm1Msd
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Rimbp2tm1.2Geno/Rimbp2tm1.2Geno,Tspoap1tm1.2Geno/Tspoap1tm1.2Geno
Genetic Background: involves: C57BL/6

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Smn1tm1Msd/Smn1tm1Msd
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0002919 enhanced paired-pulse facilitation "increase in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to greater increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Smn1tm1Msd/Smn1tm1Msd
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Rimbp2tm1.2Geno/Rimbp2tm1.2Geno,Tspoap1tm1.2Geno/Tspoap1tm1.2Geno
Genetic Background: involves: C57BL/6

 MP:0003635 abnormal synaptic transmission "defect in the communication from a neuron to a target across a synapse " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Smn1tm1Msd/Smn1tm1Msd
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0004807 abnormal paired pulse inhibition "defects in the supressive response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of inhibition of neurotransmitter release at the second stimulus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Smn1tm1Msd/Smn1tm1Msd
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Rimbp2tm1.2Geno/Rimbp2tm1.2Geno,Tspoap1tm1.2Geno/Tspoap1tm1.2Geno
Genetic Background: involves: C57BL/6

 MP:0004859 abnormal synaptic plasticity "anomaly in the ability of a synapse to change its strength as a result of successive activations" [MESH:National Library of Medicine_Medical Subject Headings, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Smn1tm1Msd/Smn1tm1Msd
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Rimbp2tm1.2Geno/Rimbp2tm1.2Geno,Tspoap1tm1.2Geno/Tspoap1tm1.2Geno
Genetic Background: involves: C57BL/6

 MP:0011270 decreased excitatory postsynaptic current amplitude "reduction in the size (height or maximum displacement) of the evoked excitatory postsynaptic current wave" [MGI:csmith]
Show

Allelic Composition: Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Smn1tm1Msd/Smn1tm1Msd
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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