ENSMUSG00000041736


Mus musculus

Features
Gene ID: ENSMUSG00000041736
  
Biological name :Tspo
  
Synonyms : P50637 / Translocator protein / Tspo
  
Possible biological names infered from orthology : B1AH88 / P30536
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: E1
Gene start: 83563592
Gene end: 83574203
  
Corresponding Affymetrix probe sets: 10425808 (MoGene1.0st)   1416695_at (Mouse Genome 430 2.0 Array)   1438948_x_at (Mouse Genome 430 2.0 Array)   1456251_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000146965
Ensembl peptide - ENSMUSP00000037039
NCBI entrez gene - 12257     See in Manteia.
MGI - MGI:88222
RefSeq - NM_009775
RefSeq Peptide - NP_033905
swissprot - A0A140LIU9
swissprot - P50637
Ensembl - ENSMUSG00000041736
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TSPOENSGALG00000014166Gallus gallus
 TSPOENSG00000100300Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tspo2 / Q9CRZ8 / Translocator protein 2 / Q5TGU0*ENSMUSG0000002399536


Protein motifs (from Interpro)
Interpro ID Name
 IPR004307  TspO/MBR-related protein
 IPR030164  Translocator protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006694 steroid biosynthetic process IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006821 chloride transport IEA
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008347 glial cell migration IEA
 biological_processGO:0010042 response to manganese ion IEA
 biological_processGO:0010266 response to vitamin B1 IEA
 biological_processGO:0010823 negative regulation of mitochondrion organization IMP
 biological_processGO:0010940 positive regulation of necrotic cell death IEA
 biological_processGO:0014012 peripheral nervous system axon regeneration IEA
 biological_processGO:0030325 adrenal gland development IEA
 biological_processGO:0031397 negative regulation of protein ubiquitination IMP
 biological_processGO:0032570 response to progesterone IEA
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IEA
 biological_processGO:0033574 response to testosterone IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0045019 negative regulation of nitric oxide biosynthetic process IEA
 biological_processGO:0048265 response to pain IEA
 biological_processGO:0048266 behavioral response to pain IEA
 biological_processGO:0048678 response to axon injury IEA
 biological_processGO:0050810 regulation of steroid biosynthetic process IEA
 biological_processGO:0051901 positive regulation of mitochondrial depolarization IEA
 biological_processGO:0051928 positive regulation of calcium ion transport IEA
 biological_processGO:0060242 contact inhibition IEA
 biological_processGO:0060252 positive regulation of glial cell proliferation IEA
 biological_processGO:0060253 negative regulation of glial cell proliferation IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071294 cellular response to zinc ion IEA
 biological_processGO:0071476 cellular hypotonic response IEA
 biological_processGO:0072655 establishment of protein localization to mitochondrion IMP
 biological_processGO:0072656 maintenance of protein location in mitochondrion IMP
 biological_processGO:1903147 negative regulation of autophagy of mitochondrion IMP
 biological_processGO:1903579 negative regulation of ATP metabolic process IMP
 biological_processGO:2000379 positive regulation of reactive oxygen species metabolic process IMP
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 molecular_functionGO:0005497 androgen binding IEA
 molecular_functionGO:0008503 benzodiazepine receptor activity IEA
 molecular_functionGO:0044325 ion channel binding IPI


Pathways (from Reactome)
Pathway description
Pregnenolone biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ift140b2b1283Clo/Ift140b2b1283Clo
Genetic Background: C57BL/6J-Ift140b2b1283Clo

 MP:0005387 immune system phenotype 
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Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0008044 increased NK cell number "greater number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Sh3pxd2aGt(OST445753)Lex/Sh3pxd2aGt(OST445753)Lex
Genetic Background: B6J.129S5-Sh3pxd2aGt(OST445753)Lex

 MP:0010956 abnormal mitochondrial ATP synthesis coupled electron transport "anomaly in the transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane and mediated by multisubunit enzyme complexes known as complex I-IV" [GO:0042775, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sh3pxd2aGt(OST445753)Lex/Sh3pxd2aGt(OST445753)Lex
Genetic Background: B6J.129S5-Sh3pxd2aGt(OST445753)Lex

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000034156 Q7TNF8 / Tspoap1 / Peripheral-type benzodiazepine receptor-associated protein 1 / O95153* / TSPO associated protein 1*  / complex






 

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