ENSG00000100300


Homo sapiens

Features
Gene ID: ENSG00000100300
  
Biological name :TSPO
  
Synonyms : B1AH88 / P30536 / translocator protein / TSPO
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: 1
Band: q13.2
Gene start: 43151514
Gene end: 43163242
  
Corresponding Affymetrix probe sets: 202096_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000379563
Ensembl peptide - ENSP00000463495
Ensembl peptide - ENSP00000405685
Ensembl peptide - ENSP00000328973
Ensembl peptide - ENSP00000338004
NCBI entrez gene - 706     See in Manteia.
OMIM - 109610
RefSeq - NM_000714
RefSeq - NM_001256530
RefSeq - NM_001256531
RefSeq Peptide - NP_000705
RefSeq Peptide - NP_001243459
RefSeq Peptide - NP_001243460
swissprot - P30536
swissprot - B1AH87
swissprot - J3QLD3
swissprot - B1AH88
Ensembl - ENSG00000100300
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TSPOENSGALG00000014166Gallus gallus
 TspoENSMUSG00000041736Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TSPO2 / Q5TGU0 / translocator protein 2ENSG0000011221237


Protein motifs (from Interpro)
Interpro ID Name
 IPR004307  TspO/MBR-related protein
 IPR030164  Translocator protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006626 protein targeting to mitochondrion TAS
 biological_processGO:0006694 steroid biosynthetic process IEA
 biological_processGO:0006700 C21-steroid hormone biosynthetic process TAS
 biological_processGO:0006783 heme biosynthetic process TAS
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006820 anion transport TAS
 biological_processGO:0006821 chloride transport IEA
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008202 steroid metabolic process TAS
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0008347 glial cell migration IEA
 biological_processGO:0010042 response to manganese ion IEA
 biological_processGO:0010266 response to vitamin B1 IEA
 biological_processGO:0010823 negative regulation of mitochondrion organization IEA
 biological_processGO:0010940 positive regulation of necrotic cell death IEA
 biological_processGO:0014012 peripheral nervous system axon regeneration IEA
 biological_processGO:0030301 cholesterol transport IEA
 biological_processGO:0030325 adrenal gland development IEA
 biological_processGO:0031397 negative regulation of protein ubiquitination IEA
 biological_processGO:0032374 regulation of cholesterol transport TAS
 biological_processGO:0032570 response to progesterone IEA
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IEA
 biological_processGO:0033574 response to testosterone IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0045019 negative regulation of nitric oxide biosynthetic process IEA
 biological_processGO:0048265 response to pain IEA
 biological_processGO:0048266 behavioral response to pain IEA
 biological_processGO:0048678 response to axon injury IEA
 biological_processGO:0050810 regulation of steroid biosynthetic process IEA
 biological_processGO:0051901 positive regulation of mitochondrial depolarization IEA
 biological_processGO:0051928 positive regulation of calcium ion transport IEA
 biological_processGO:0060242 contact inhibition IEA
 biological_processGO:0060252 positive regulation of glial cell proliferation IEA
 biological_processGO:0060253 negative regulation of glial cell proliferation IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071294 cellular response to zinc ion IEA
 biological_processGO:0071476 cellular hypotonic response IEA
 biological_processGO:0072655 establishment of protein localization to mitochondrion IEA
 biological_processGO:0072656 maintenance of protein location in mitochondrion IEA
 biological_processGO:1903147 negative regulation of autophagy of mitochondrion IEA
 biological_processGO:1903579 negative regulation of ATP metabolic process IEA
 biological_processGO:2000379 positive regulation of reactive oxygen species metabolic process IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane NAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005497 androgen binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008503 benzodiazepine receptor activity TAS
 molecular_functionGO:0015485 cholesterol binding TAS
 molecular_functionGO:0017127 cholesterol transporter activity TAS
 molecular_functionGO:0044325 ion channel binding IEA


Pathways (from Reactome)
Pathway description
Pregnenolone biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000005379 O95153 / TSPOAP1 / TSPO associated protein 1  / complex






 

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