ENSMUSG00000040606


Mus musculus

Features
Gene ID: ENSMUSG00000040606
  
Biological name :Kazn
  
Synonyms : Kazn / Kazrin / Q69ZS8
  
Possible biological names infered from orthology : kazrin, periplakin interacting protein / Q674X7
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: E1
Gene start: 142102390
Gene end: 142239401
  
Corresponding Affymetrix probe sets: 10518113 (MoGene1.0st)   1431711_a_at (Mouse Genome 430 2.0 Array)   1434169_at (Mouse Genome 430 2.0 Array)   1435624_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134631
Ensembl peptide - ENSMUSP00000115897
Ensembl peptide - ENSMUSP00000134498
Ensembl peptide - ENSMUSP00000038835
Ensembl peptide - ENSMUSP00000133972
Ensembl peptide - ENSMUSP00000116071
NCBI entrez gene - 71529     See in Manteia.
MGI - MGI:1918779
RefSeq - NM_001109684
RefSeq - NM_144531
RefSeq - NM_001109685
RefSeq Peptide - NP_001103155
RefSeq Peptide - NP_001103154
RefSeq Peptide - NP_653114
swissprot - Q69ZS8
swissprot - B7ZCA7
swissprot - F6RLJ7
swissprot - G3UY74
swissprot - G3UZH4
swissprot - G3UZT9
Ensembl - ENSMUSG00000040606
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kaznaENSDARG00000076923Danio rerio
 kaznbENSDARG00000006601Danio rerio
 KAZNENSGALG00000013642Gallus gallus
 KAZNENSG00000189337Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ppfia4 / protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 / O75335* / PTPRF interacting protein alpha 4*ENSMUSG0000002645825
Ppfia1 / protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 / Q13136* / PTPRF interacting protein alpha 1*ENSMUSG0000003751924
Ppfia2 / protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 / O75334* / PTPRF interacting protein alpha 2*ENSMUSG0000005382524
P60469 / Ppfia3 / protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 / O75145* / PTPRF interacting protein alpha 3*ENSMUSG0000000386323
O35711 / Ppfibp2 / PTPRF interacting protein, binding protein 2 (liprin beta 2) / Q8ND30* / PPFIA binding protein 2*ENSMUSG0000003652812
Q8C8U0 / Ppfibp1 / PTPRF interacting protein, binding protein 1 (liprin beta 1) / Q86W92* / PPFIA binding protein 1*ENSMUSG0000001648712


Protein motifs (from Interpro)
Interpro ID Name
 IPR001660  Sterile alpha motif domain
 IPR013761  Sterile alpha motif/pointed domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0031424 keratinization IEA
 cellular_componentGO:0001533 cornified envelope ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016607 nuclear speck ISO
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030057 desmosome ISO
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Hdac8tm1a(EUCOMM)Wtsi/Hdac8tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Hdac8tm1a(EUCOMM)Wtsi/Wtsi

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hdac8tm1a(EUCOMM)Wtsi/Hdac8tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Hdac8tm1a(EUCOMM)Wtsi/Wtsi

 MP:0005632 decreased circulating aspartate transaminase level "less than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Hdac8tm1a(EUCOMM)Wtsi/Hdac8tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Hdac8tm1a(EUCOMM)Wtsi/Wtsi

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hdac8tm1a(EUCOMM)Wtsi/Hdac8tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Hdac8tm1a(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000039457 Ppl / periplakin / O60437*  / reaction / complex






 

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