ENSG00000106278


Homo sapiens

Features
Gene ID: ENSG00000106278
  
Biological name :PTPRZ1
  
Synonyms : P23471 / protein tyrosine phosphatase, receptor type Z1 / PTPRZ1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: q31.32
Gene start: 121873089
Gene end: 122062036
  
Corresponding Affymetrix probe sets: 204469_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000377047
Ensembl peptide - ENSP00000410000
NCBI entrez gene - 5803     See in Manteia.
OMIM - 176891
RefSeq - XM_017012477
RefSeq - NM_001206838
RefSeq - NM_001206839
RefSeq - NM_002851
RefSeq - XM_005250519
RefSeq Peptide - NP_002842
RefSeq Peptide - NP_001193767
RefSeq Peptide - NP_001193768
swissprot - P23471
Ensembl - ENSG00000106278
  
Related genetic diseases (OMIM): 600263 - {H. pylori infection, susceptibility to}, 600263
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptprz1aENSDARG00000051814Danio rerio
 ptprz1bENSDARG00000020871Danio rerio
 PTPRZ1ENSGALG00000040114Gallus gallus
 B9EKR1ENSMUSG00000068748Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PTPRG / P23470 / protein tyrosine phosphatase, receptor type GENSG0000014472431
PTPRS / Q13332 / protein tyrosine phosphatase, receptor type SENSG0000010542619
PTPRD / P23468 / protein tyrosine phosphatase, receptor type DENSG0000015370719
PTPRF / P10586 / protein tyrosine phosphatase, receptor type FENSG0000014294918
PTPRM / P28827 / protein tyrosine phosphatase, receptor type MENSG0000017348214
PTPRT / O14522 / protein tyrosine phosphatase, receptor type TENSG0000019609014
PTPRK / Q15262 / protein tyrosine phosphatase, receptor type KENSG0000015289414
PTPRU / Q92729 / protein tyrosine phosphatase, receptor type UENSG0000006065613
PTPRC / protein tyrosine phosphatase, receptor type CENSG0000008123712
PTPRA / P18433 / protein tyrosine phosphatase, receptor type AENSG0000013267010
PTPRE / P23469 / protein tyrosine phosphatase, receptor type EENSG0000013233410


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR001148  Alpha carbonic anhydrase domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR029021  Protein-tyrosine phosphatase-like
 IPR036116  Fibronectin type III superfamily
 IPR036398  Alpha carbonic anhydrase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IEA
 biological_processGO:0006470 protein dephosphorylation TAS
 biological_processGO:0007409 axonogenesis IEA
 biological_processGO:0007417 central nervous system development TAS
 biological_processGO:0007611 learning or memory ISS
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation ISS
 biological_processGO:0048709 oligodendrocyte differentiation ISS
 biological_processGO:0070445 regulation of oligodendrocyte progenitor proliferation ISS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031226 intrinsic component of plasma membrane ISS
 cellular_componentGO:0072534 perineuronal net IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity ISS
 molecular_functionGO:0005001 transmembrane receptor protein tyrosine phosphatase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA


Pathways (from Reactome)
Pathway description
Other interleukin signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000157368 IL34 / Q6ZMJ4 / interleukin 34  / complex / reaction






 

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