ENSG00000152894


Homo sapiens

Features
Gene ID: ENSG00000152894
  
Biological name :PTPRK
  
Synonyms : protein tyrosine phosphatase, receptor type K / PTPRK / Q15262
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: q22.33
Gene start: 127968779
Gene end: 128520674
  
Corresponding Affymetrix probe sets: 203038_at (Human Genome U133 Plus 2.0 Array)   233609_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000432973
Ensembl peptide - ENSP00000432960
Ensembl peptide - ENSP00000434058
Ensembl peptide - ENSP00000437299
Ensembl peptide - ENSP00000434116
Ensembl peptide - ENSP00000357190
Ensembl peptide - ENSP00000357193
Ensembl peptide - ENSP00000357196
Ensembl peptide - ENSP00000357198
Ensembl peptide - ENSP00000357209
Ensembl peptide - ENSP00000376243
Ensembl peptide - ENSP00000406825
Ensembl peptide - ENSP00000408180
NCBI entrez gene - 5796     See in Manteia.
OMIM - 602545
RefSeq - XM_017011148
RefSeq - NM_001135648
RefSeq - NM_001291981
RefSeq - NM_001291982
RefSeq - NM_001291983
RefSeq - NM_001291984
RefSeq - NM_002844
RefSeq - XM_006715537
RefSeq - XM_011536014
RefSeq - XM_011536015
RefSeq - XM_011536016
RefSeq - XM_011536017
RefSeq - XM_011536018
RefSeq - XM_017011145
RefSeq - XM_017011146
RefSeq - XM_017011147
RefSeq Peptide - NP_001278911
RefSeq Peptide - NP_001278913
RefSeq Peptide - NP_002835
RefSeq Peptide - NP_001129120
RefSeq Peptide - NP_001278910
RefSeq Peptide - NP_001278912
swissprot - H0YDP9
swissprot - Q6P493
swissprot - E9PGC5
swissprot - Q15262
swissprot - Q5TG12
swissprot - E9PRW2
swissprot - E9PMV4
swissprot - H0Y6P5
swissprot - H0Y6V4
swissprot - H0YD44
Ensembl - ENSG00000152894
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptprkENSDARG00000063416Danio rerio
 PTPRKENSGALG00000037423Gallus gallus
 PtprkENSMUSG00000019889Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PTPRM / P28827 / protein tyrosine phosphatase, receptor type MENSG0000017348261
PTPRU / Q92729 / protein tyrosine phosphatase, receptor type UENSG0000006065659
PTPRT / O14522 / protein tyrosine phosphatase, receptor type TENSG0000019609057
PTPRD / P23468 / protein tyrosine phosphatase, receptor type DENSG0000015370728
PTPRF / P10586 / protein tyrosine phosphatase, receptor type FENSG0000014294928
PTPRS / Q13332 / protein tyrosine phosphatase, receptor type SENSG0000010542627
P23471 / PTPRZ1 / protein tyrosine phosphatase, receptor type Z1ENSG0000010627821
PTPRC / protein tyrosine phosphatase, receptor type CENSG0000008123720
PTPRG / P23470 / protein tyrosine phosphatase, receptor type GENSG0000014472419
PTPRA / P18433 / protein tyrosine phosphatase, receptor type AENSG0000013267018
PTPRE / P23469 / protein tyrosine phosphatase, receptor type EENSG0000013233417


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR000998  MAM domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR029021  Protein-tyrosine phosphatase-like
 IPR036116  Fibronectin type III superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007155 cell adhesion IMP
 biological_processGO:0007165 signal transduction IDA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IDA
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0010839 negative regulation of keratinocyte proliferation IDA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0030336 negative regulation of cell migration IDA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0034394 protein localization to cell surface IDA
 biological_processGO:0034614 cellular response to reactive oxygen species IDA
 biological_processGO:0034644 cellular response to UV IDA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0045786 negative regulation of cell cycle IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0048041 focal adhesion assembly IMP
 cellular_componentGO:0001750 photoreceptor outer segment IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane NAS
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0005912 adherens junction IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IDA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031256 leading edge membrane IDA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0005001 transmembrane receptor protein tyrosine phosphatase activity NAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008013 beta-catenin binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0045295 gamma-catenin binding IPI


Pathways (from Reactome)
Pathway description
EGFR downregulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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