ENSMUSG00000000058


Mus musculus

Features
Gene ID: ENSMUSG00000000058
  
Biological name :Cav2
  
Synonyms : Cav2 / Caveolin-2 / Q9WVC3
  
Possible biological names infered from orthology : P51636
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: A2
Gene start: 17281185
Gene end: 17289115
  
Corresponding Affymetrix probe sets: 10536494 (MoGene1.0st)   1417327_at (Mouse Genome 430 2.0 Array)   1425955_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000000058
Ensembl peptide - ENSMUSP00000111119
Ensembl peptide - ENSMUSP00000111122
NCBI entrez gene - 12390     See in Manteia.
MGI - MGI:107571
RefSeq - NM_001277756
RefSeq - NM_016900
RefSeq Peptide - NP_001264685
RefSeq Peptide - NP_058596
swissprot - Q9WVC3
swissprot - Q924U4
swissprot - D3Z147
Ensembl - ENSMUSG00000000058
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cav2ENSDARG00000052000Danio rerio
 CAV2ENSGALG00000033295Gallus gallus
 CAV2ENSG00000105971Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cav1 / P49817 / Caveolin-1 / Q03135*ENSMUSG0000000765533
Cav3 / P51637 / Caveolin-3 / P56539*ENSMUSG0000006269431


Protein motifs (from Interpro)
Interpro ID Name
 IPR001612  Caveolin
 IPR018361  Caveolin, conserved site
 IPR033306  Caveolin-2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001937 negative regulation of endothelial cell proliferation IMP
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IGI
 biological_processGO:0006897 endocytosis TAS
 biological_processGO:0006906 vesicle fusion IEA
 biological_processGO:0007005 mitochondrion organization IMP
 biological_processGO:0007029 endoplasmic reticulum organization IMP
 biological_processGO:0007088 regulation of mitotic nuclear division IEA
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0008286 insulin receptor signaling pathway IEA
 biological_processGO:0016050 vesicle organization IEA
 biological_processGO:0019065 receptor-mediated endocytosis of virus by host cell IEA
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IGI
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0044791 positive regulation by host of viral release from host cell IEA
 biological_processGO:0044794 positive regulation by host of viral process IEA
 biological_processGO:0048278 vesicle docking ISS
 biological_processGO:0048741 skeletal muscle fiber development IMP
 biological_processGO:0051259 protein complex oligomerization IDA
 biological_processGO:0060161 positive regulation of dopamine receptor signaling pathway ISS
 biological_processGO:0070836 caveola assembly IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0002080 acrosomal membrane IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030133 transport vesicle IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0030674 protein binding, bridging IDA
 molecular_functionGO:0031748 D1 dopamine receptor binding ISS
 molecular_functionGO:0032947 protein-containing complex scaffold activity IDA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IPI
 molecular_functionGO:0097110 scaffold protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000730 increased number of satellite cells "greater number of unfused cells in muscle that play a role in muscle regeneration" [J:42574]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0000750 abnormal muscle regeneration "inability or defects in ability to repair muscle after injuries" [J:42574]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0001179 thicker alveolar septa 
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
Show

Allelic Composition: Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

 MP:0003448 altered tumor morphology "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

 MP:0004272 abnormal basement membrane morphology "anomaly in the structure, organization and/or placement of the extracellular supportive tissue adjacent to the basal surface of the epithelia, including the epithelium of muscle cells, fat cells and Schwann cells; it is comprised of type IV collagen, laminin, and sulfated proteoglycans and other components and consists of two layers, the basal lamina and the lamina reticularis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A10.272.220]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0009399 increased skeletal muscle fiber size "increase in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0010144 abnormal tumor vascularization "aberrant process of blood vessel formation and the subsequent remodeling process within and/or around tumors" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

 MP:0010537 tumor regression "a decrease in tumor size from a formerly larger state and/or a decrease in the extent of tumors in the body" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

 MP:0010639 altered tumor pathology "any changes associated with the chemistry, immunohistology, cellular alterations or environmental interactions of tumors compared to the expected state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

 MP:0012106 impaired exercise endurance "impaired performance during controlled physical activity" [MGI:smb]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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