ENSMUSG00000071866


Mus musculus

Features
Gene ID: ENSMUSG00000071866
  
Biological name :Ppia
  
Synonyms : P17742 / peptidylprolyl isomerase A / Ppia
  
Possible biological names infered from orthology : P62937
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: A1
Gene start: 6415443
Gene end: 6419817
  
Corresponding Affymetrix probe sets: 10374175 (MoGene1.0st)   10441396 (MoGene1.0st)   10482507 (MoGene1.0st)   10545337 (MoGene1.0st)   10567574 (MoGene1.0st)   10588024 (MoGene1.0st)   1417451_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117987
Ensembl peptide - ENSMUSP00000150020
Ensembl peptide - ENSMUSP00000149662
NCBI entrez gene - 268373     See in Manteia.
MGI - MGI:97749
RefSeq - NM_008907
RefSeq Peptide - NP_032933
swissprot - A0A1L1SRX5
swissprot - A0A1L1SST0
swissprot - P17742
swissprot - Q5SVY2
Ensembl - ENSMUSG00000071866
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PPIAENSGALG00000028600Gallus gallus
 PPIAENSG00000196262Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm5160 / PPIA* / P62937* / peptidylprolyl isomerase A*ENSMUSG0000005579580
Ppif / Q99KR7 / Peptidyl-prolyl cis-trans isomerase F, mitochondrial / P30405* / peptidylprolyl isomerase F*ENSMUSG0000002186877
Q9ERU9 / Ranbp2 / E3 SUMO-protein ligase RanBP2 / RGPD3* / RGPD2* / RGPD1* / RGPD8* / RGPD6* / RGPD5* / RGPD4* / A6NKT7* / O14715* / P0DJD0* / P0DJD1* / P49792* / Q7Z3J3* / Q99666* / RAN b...ENSMUSG0000000322667
Ppie / Q9QZH3 / Peptidyl-prolyl cis-trans isomerase E / Q9UNP9* / peptidylprolyl isomerase E*ENSMUSG0000002865166
Gm12728ENSMUSG0000008378039


Protein motifs (from Interpro)
Interpro ID Name
 IPR002130  Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
 IPR020892  Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
 IPR024936  Cyclophilin-type peptidyl-prolyl cis-trans isomerase
 IPR029000  Cyclophilin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000413 protein peptidyl-prolyl isomerization IEA
 biological_processGO:0006457 protein folding IEA
 biological_processGO:0030182 neuron differentiation IMP
 biological_processGO:0034389 lipid particle organization ISO
 biological_processGO:0045069 regulation of viral genome replication ISO
 biological_processGO:0045070 positive regulation of viral genome replication ISO
 biological_processGO:0050714 positive regulation of protein secretion ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0043209 myelin sheath IDA
 molecular_functionGO:0003755 peptidyl-prolyl cis-trans isomerase activity IEA
 molecular_functionGO:0016018 cyclosporin A binding ISO
 molecular_functionGO:0016853 isomerase activity IEA


Pathways (from Reactome)
Pathway description
Basigin interactions
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
Show

Allelic Composition: Lattm1Les/Lattm1Les,Lat2tm1Wz/Lat2tm1Wz
Genetic Background: involves: C57BL/6

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lattm1Les/Lattm1Les,Lat2tm1Wz/Lat2tm1Wz
Genetic Background: involves: C57BL/6

 MP:0001853 heart inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the heart" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lattm1Les/Lattm1Les,Lat2tm1Wz/Lat2tm1Wz
Genetic Background: involves: C57BL/6

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Lattm1Les/Lattm1Les,Lat2tm1Wz/Lat2tm1Wz
Genetic Background: involves: C57BL/6

 MP:0001869 pancreas inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the pancreas " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Lattm1Les/Lattm1Les,Lat2tm1Wz/Lat2tm1Wz
Genetic Background: involves: C57BL/6

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lattm1Les/Lattm1Les,Lat2tm1Wz/Lat2tm1Wz
Genetic Background: involves: C57BL/6

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lattm1Les/Lattm1Les,Lat2tm1Wz/Lat2tm1Wz
Genetic Background: involves: C57BL/6

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lattm1Les/Lattm1Les,Lat2tm1Wz/Lat2tm1Wz
Genetic Background: involves: C57BL/6

 MP:0005251 blepharitis "inflammation of the eyelids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lattm1Les/Lattm1Les,Lat2tm1Wz/Lat2tm1Wz
Genetic Background: involves: C57BL/6

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lattm1Les/Lattm1Les,Lat2tm1Wz/Lat2tm1Wz
Genetic Background: involves: C57BL/6

 MP:0005596 increased susceptibility to type I hypersensitvity reaction "greater likelihood of developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lattm1Les/Lattm1Les,Lat2tm1Wz/Lat2tm1Wz
Genetic Background: involves: C57BL/6

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Lattm1Les/Lattm1Les,Lat2tm1Wz/Lat2tm1Wz
Genetic Background: involves: C57BL/6

 MP:0008602 increased circulating interleukin-4 level "increase in the amount in the blood of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Lattm1Les/Lattm1Les,Lat2tm1Wz/Lat2tm1Wz
Genetic Background: involves: C57BL/6

 MP:0008687 increased interleukin-2 secretion "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Lattm1Les/Lattm1Les,Lat2tm1Wz/Lat2tm1Wz
Genetic Background: involves: C57BL/6

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Lattm1Les/Lattm1Les,Lat2tm1Wz/Lat2tm1Wz
Genetic Background: involves: C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Lattm1Les/Lattm1Les,Lat2tm1Wz/Lat2tm1Wz
Genetic Background: involves: C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Lattm1Les/Lattm1Les,Lat2tm1Wz/Lat2tm1Wz
Genetic Background: involves: C57BL/6

Allelic Composition: Ppiatm1Lubn/Ppiatm1Lubn
Genetic Background: 129S6.129P2-Ppiatm1Lubn

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000023175 Bsg / P18572 / Basigin / P35613* / basigin (Ok blood group)*  / reaction / complex






 

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