ENSMUSG00000021868


Mus musculus

Features
Gene ID: ENSMUSG00000021868
  
Biological name :Ppif
  
Synonyms : Peptidyl-prolyl cis-trans isomerase F, mitochondrial / Ppif / Q99KR7
  
Possible biological names infered from orthology : P30405 / peptidylprolyl isomerase F
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: A3
Gene start: 25694154
Gene end: 25700468
  
Corresponding Affymetrix probe sets: 10413222 (MoGene1.0st)   1416940_at (Mouse Genome 430 2.0 Array)   1438955_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022419
NCBI entrez gene - 105675     See in Manteia.
MGI - MGI:2145814
RefSeq - NM_134084
RefSeq - XM_017315774
RefSeq Peptide - NP_598845
swissprot - Q99KR7
Ensembl - ENSMUSG00000021868
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppifbENSDARG00000052842Danio rerio
 PPIFENSGALG00000004809Gallus gallus
 PPIFENSG00000108179Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ppia / P17742 / peptidylprolyl isomerase A / P62937*ENSMUSG0000007186661
Q9ERU9 / Ranbp2 / E3 SUMO-protein ligase RanBP2 / RGPD3* / RGPD2* / RGPD1* / RGPD8* / RGPD6* / RGPD5* / RGPD4* / A6NKT7* / O14715* / P0DJD0* / P0DJD1* / P49792* / Q7Z3J3* / Q99666* / RAN b...ENSMUSG0000000322657
Ppie / Q9QZH3 / Peptidyl-prolyl cis-trans isomerase E / Q9UNP9* / peptidylprolyl isomerase E*ENSMUSG0000002865156
Gm5160 / PPIA* / P62937* / peptidylprolyl isomerase A*ENSMUSG0000005579548
Gm12728ENSMUSG0000008378023


Protein motifs (from Interpro)
Interpro ID Name
 IPR002130  Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
 IPR020892  Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
 IPR024936  Cyclophilin-type peptidyl-prolyl cis-trans isomerase
 IPR029000  Cyclophilin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000413 protein peptidyl-prolyl isomerization TAS
 biological_processGO:0002931 response to ischemia IMP
 biological_processGO:0006457 protein folding IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006979 response to oxidative stress IGI
 biological_processGO:0008637 apoptotic mitochondrial changes IGI
 biological_processGO:0010849 regulation of proton-transporting ATPase activity, rotational mechanism IMP
 biological_processGO:0010939 regulation of necrotic cell death IDA
 biological_processGO:0012501 programmed cell death IEA
 biological_processGO:0032780 negative regulation of ATPase activity IMP
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0046902 regulation of mitochondrial membrane permeability IEA
 biological_processGO:0070266 necroptotic process IGI
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0071243 cellular response to arsenic-containing substance IMP
 biological_processGO:0071277 cellular response to calcium ion IMP
 biological_processGO:0090200 positive regulation of release of cytochrome c from mitochondria IMP
 biological_processGO:0090201 negative regulation of release of cytochrome c from mitochondria IEA
 biological_processGO:0090324 negative regulation of oxidative phosphorylation IMP
 biological_processGO:1902445 regulation of mitochondrial membrane permeability involved in programmed necrotic cell death IMP
 biological_processGO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death IEA
 biological_processGO:2000276 negative regulation of oxidative phosphorylation uncoupler activity IMP
 biological_processGO:2001243 negative regulation of intrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005753 mitochondrial proton-transporting ATP synthase complex ISS
 cellular_componentGO:0005757 mitochondrial permeability transition pore complex IEA
 cellular_componentGO:0005759 mitochondrial matrix IBA
 molecular_functionGO:0003755 peptidyl-prolyl cis-trans isomerase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016018 cyclosporin A binding IEA
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0042277 peptide binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Grid2ho/Grid2ho
Genetic Background: involves: C57BLKS/J

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Grid2ho/Grid2ho
Genetic Background: involves: C57BLKS/J

 MP:0003038 decreased infarction size "decreased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Grid2tm1(cre/PGR)Ksak/Grid2tm2Mim
Genetic Background: involves: C57BL/6

Allelic Composition: Ppiftm1Tsu/Ppiftm1Tsu
Genetic Background: involves: 129S5/SvEvBrd

 MP:0006036 abnormal mitochondrial physiology 
Show

Allelic Composition: Grid2tm1(cre/PGR)Ksak/Grid2tm2Mim
Genetic Background: involves: C57BL/6

Allelic Composition: Ppiftm1Tsu/Ppiftm1Tsu
Genetic Background: involves: 129S5/SvEvBrd

Allelic Composition: Ppiftm1Maf/Ppiftm1Maf
Genetic Background: B6.129-Ppiftm1Maf

Allelic Composition: Ppiftm1.1Mmos/Ppiftm1.1Mmos
Genetic Background: involves: 129X1/SvJ * FVB/NJ

 MP:0006058 decreased cerebral infarction size "decreased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ppiftm1.1Mmos/Ppiftm1.1Mmos
Genetic Background: involves: 129X1/SvJ * FVB/NJ

Allelic Composition: Ppiftm1.1Mmos/Ppif+
Genetic Background: involves: 129X1/SvJ * FVB/NJ

 MP:0008407 decreased cellular sensitivity to hydrogen peroxide "reduced incidence of cell death following exposure to hydrogen peroxide" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ppiftm1Tsu/Ppiftm1Tsu
Genetic Background: involves: 129S5/SvEvBrd

 MP:0008944 decreased sensitivity to induced cell death "increase in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ppiftm1Tsu/Ppiftm1Tsu
Genetic Background: involves: 129S5/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr