ENSG00000108179


Homo sapiens

Features
Gene ID: ENSG00000108179
  
Biological name :PPIF
  
Synonyms : P30405 / peptidylprolyl isomerase F / PPIF
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: q22.3
Gene start: 79347469
Gene end: 79355337
  
Corresponding Affymetrix probe sets: 201489_at (Human Genome U133 Plus 2.0 Array)   201490_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000473548
Ensembl peptide - ENSP00000225174
Ensembl peptide - ENSP00000396388
NCBI entrez gene - 10105     See in Manteia.
OMIM - 604486
RefSeq - XM_005269379
RefSeq - NM_005729
RefSeq Peptide - NP_005720
swissprot - A0A024QZS4
swissprot - P30405
swissprot - R4GN99
swissprot - H0Y548
Ensembl - ENSG00000108179
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppifbENSDARG00000052842Danio rerio
 PPIFENSGALG00000004809Gallus gallus
 PpifENSMUSG00000021868Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PPIA / P62937 / peptidylprolyl isomerase AENSG0000019626260
P49792 / RANBP2 / RAN binding protein 2ENSG0000015320156
PPIE / Q9UNP9 / peptidylprolyl isomerase EENSG0000008407256
PPIAL4C / A0A0B4J2A2 / peptidylprolyl isomerase A like 4CENSG0000026346453
Q9Y536 / PPIAL4A / peptidylprolyl isomerase A like 4AENSG0000026335352
P0DN37 / PPIAL4G / peptidylprolyl isomerase A like 4GENSG0000023633452
F5H284 / PPIAL4D / peptidylprolyl isomerase A like 4DENSG0000025637452
PPIAL4E / A0A075B759 / peptidylprolyl isomerase A like 4EENSG0000027156752
P0DN26 / PPIAL4F / peptidylprolyl isomerase A like 4FENSG0000027978252
AC243756.1ENSG0000027033951
RGPD5 / Q99666 / RANBP2-like and GRIP domain containing 5ENSG0000001556812
RGPD6 / Q99666 / RANBP2-like and GRIP domain containing 6ENSG0000018305412
RGPD2 / P0DJD1 / RANBP2-like and GRIP domain containing 2ENSG0000018530412
RGPD8 / O14715 / RANBP2-like and GRIP domain containing 8ENSG0000016962912
RGPD3 / A6NKT7 / RANBP2-like and GRIP domain containing 3ENSG0000015316511
RGPD1 / P0DJD0 / RANBP2-like and GRIP domain containing 1ENSG0000018762711
RGPD4 / Q7Z3J3 / RANBP2-like and GRIP domain containing 4ENSG0000019686211


Protein motifs (from Interpro)
Interpro ID Name
 IPR002130  Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
 IPR020892  Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
 IPR024936  Cyclophilin-type peptidyl-prolyl cis-trans isomerase
 IPR029000  Cyclophilin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000413 protein peptidyl-prolyl isomerization IEA
 biological_processGO:0002931 response to ischemia ISS
 biological_processGO:0006457 protein folding IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0008637 apoptotic mitochondrial changes IEA
 biological_processGO:0010849 regulation of proton-transporting ATPase activity, rotational mechanism ISS
 biological_processGO:0010939 regulation of necrotic cell death IEA
 biological_processGO:0012501 programmed cell death IEA
 biological_processGO:0032780 negative regulation of ATPase activity ISS
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0046902 regulation of mitochondrial membrane permeability ISS
 biological_processGO:0070266 necroptotic process IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IMP
 biological_processGO:0071243 cellular response to arsenic-containing substance ISS
 biological_processGO:0071277 cellular response to calcium ion ISS
 biological_processGO:0090200 positive regulation of release of cytochrome c from mitochondria ISS
 biological_processGO:0090201 negative regulation of release of cytochrome c from mitochondria IDA
 biological_processGO:0090324 negative regulation of oxidative phosphorylation ISS
 biological_processGO:1902445 regulation of mitochondrial membrane permeability involved in programmed necrotic cell death IMP
 biological_processGO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death IMP
 biological_processGO:2000276 negative regulation of oxidative phosphorylation uncoupler activity ISS
 biological_processGO:2001243 negative regulation of intrinsic apoptotic signaling pathway IMP
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005753 mitochondrial proton-transporting ATP synthase complex ISS
 cellular_componentGO:0005757 mitochondrial permeability transition pore complex IDA
 cellular_componentGO:0005759 mitochondrial matrix IBA
 cellular_componentGO:0016020 membrane TAS
 molecular_functionGO:0003755 peptidyl-prolyl cis-trans isomerase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016018 cyclosporin A binding IEA
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0042277 peptide binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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