ENSG00000084072


Homo sapiens

Features
Gene ID: ENSG00000084072
  
Biological name :PPIE
  
Synonyms : peptidylprolyl isomerase E / PPIE / Q9UNP9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p34.2
Gene start: 39692182
Gene end: 39763914
  
Corresponding Affymetrix probe sets: 202494_at (Human Genome U133 Plus 2.0 Array)   210502_s_at (Human Genome U133 Plus 2.0 Array)   229375_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000361925
Ensembl peptide - ENSP00000436689
Ensembl peptide - ENSP00000434989
Ensembl peptide - ENSP00000434888
Ensembl peptide - ENSP00000433475
Ensembl peptide - ENSP00000432396
Ensembl peptide - ENSP00000431714
Ensembl peptide - ENSP00000312769
Ensembl peptide - ENSP00000348904
Ensembl peptide - ENSP00000361918
NCBI entrez gene - 10450     See in Manteia.
OMIM - 602435
RefSeq - XM_017000052
RefSeq - NM_001195007
RefSeq - NM_001319293
RefSeq - NM_006112
RefSeq - NM_203456
RefSeq - XM_006710289
RefSeq - XM_006710290
RefSeq - XM_011540501
RefSeq - XM_017000051
RefSeq Peptide - NP_001181936
RefSeq Peptide - NP_001306222
RefSeq Peptide - NP_006103
RefSeq Peptide - NP_982281
swissprot - Q9UNP9
swissprot - E9PKY5
swissprot - H0YCV4
swissprot - H0YE31
swissprot - E9PEQ6
swissprot - E9PMH0
swissprot - E9PK21
swissprot - E9PIB0
Ensembl - ENSG00000084072
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppieENSDARG00000103234Danio rerio
 PPIEENSGALG00000013383Gallus gallus
 PpieENSMUSG00000028651Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P49792 / RANBP2 / RAN binding protein 2ENSG0000015320140
PPIF / P30405 / peptidylprolyl isomerase FENSG0000010817937
PPIA / P62937 / peptidylprolyl isomerase AENSG0000019626235
PPIAL4E / A0A075B759 / peptidylprolyl isomerase A like 4EENSG0000027156732
F5H284 / PPIAL4D / peptidylprolyl isomerase A like 4DENSG0000025637432
PPIAL4C / A0A0B4J2A2 / peptidylprolyl isomerase A like 4CENSG0000026346432
P0DN26 / PPIAL4F / peptidylprolyl isomerase A like 4FENSG0000027978232
Q9Y536 / PPIAL4A / peptidylprolyl isomerase A like 4AENSG0000026335332
AC243756.1ENSG0000027033931
P0DN37 / PPIAL4G / peptidylprolyl isomerase A like 4GENSG0000023633431
RGPD1 / P0DJD0 / RANBP2-like and GRIP domain containing 1ENSG0000018762714
RGPD6 / Q99666 / RANBP2-like and GRIP domain containing 6ENSG0000018305414
RGPD8 / O14715 / RANBP2-like and GRIP domain containing 8ENSG0000016962914
RGPD5 / Q99666 / RANBP2-like and GRIP domain containing 5ENSG0000001556814
RGPD2 / P0DJD1 / RANBP2-like and GRIP domain containing 2ENSG0000018530414
RGPD3 / A6NKT7 / RANBP2-like and GRIP domain containing 3ENSG0000015316513
RGPD4 / Q7Z3J3 / RANBP2-like and GRIP domain containing 4ENSG0000019686213


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR002130  Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
 IPR016304  Peptidyl-prolyl cis-trans isomerase E
 IPR020892  Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
 IPR024936  Cyclophilin-type peptidyl-prolyl cis-trans isomerase
 IPR029000  Cyclophilin-like domain superfamily
 IPR034168  Peptidyl-prolyl cis-trans isomerase E, RNA recognition motif
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000398 mRNA splicing, via spliceosome TAS
 biological_processGO:0000413 protein peptidyl-prolyl isomerization IEA
 biological_processGO:0006283 transcription-coupled nucleotide-excision repair TAS
 biological_processGO:0006355 regulation of transcription, DNA-templated IMP
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006457 protein folding IEA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0045070 positive regulation of viral genome replication IMP
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005681 spliceosomal complex IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016607 nuclear speck IDA
 cellular_componentGO:0034774 secretory granule lumen TAS
 cellular_componentGO:0071007 U2-type catalytic step 2 spliceosome IDA
 cellular_componentGO:0071013 catalytic step 2 spliceosome IDA
 cellular_componentGO:1904813 ficolin-1-rich granule lumen TAS
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding TAS
 molecular_functionGO:0003729 mRNA binding IDA
 molecular_functionGO:0003755 peptidyl-prolyl cis-trans isomerase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008143 poly(A) binding IDA
 molecular_functionGO:0016018 cyclosporin A binding TAS
 molecular_functionGO:0016853 isomerase activity IEA


Pathways (from Reactome)
Pathway description
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Neutrophil degranulation
mRNA Splicing - Major Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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