ENSG00000196262


Homo sapiens

Features
Gene ID: ENSG00000196262
  
Biological name :PPIA
  
Synonyms : P62937 / peptidylprolyl isomerase A / PPIA
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: p13
Gene start: 44796680
Gene end: 44824564
  
Corresponding Affymetrix probe sets: 201293_x_at (Human Genome U133 Plus 2.0 Array)   211378_x_at (Human Genome U133 Plus 2.0 Array)   211765_x_at (Human Genome U133 Plus 2.0 Array)   211978_x_at (Human Genome U133 Plus 2.0 Array)   212661_x_at (Human Genome U133 Plus 2.0 Array)   217602_at (Human Genome U133 Plus 2.0 Array)   226336_at (Human Genome U133 Plus 2.0 Array)   235741_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000427976
Ensembl peptide - ENSP00000429251
Ensembl peptide - ENSP00000479961
Ensembl peptide - ENSP00000430817
Ensembl peptide - ENSP00000394670
Ensembl peptide - ENSP00000405975
Ensembl peptide - ENSP00000419425
NCBI entrez gene - 5478     See in Manteia.
OMIM - 123840
RefSeq - NM_001300981
RefSeq - NM_021130
RefSeq Peptide - NP_001287910
RefSeq Peptide - NP_066953
swissprot - E5RIZ5
swissprot - V9HWF5
swissprot - C9J5S7
swissprot - F8WE65
swissprot - P62937
Ensembl - ENSG00000196262
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PPIAENSGALG00000028600Gallus gallus
 Gm5160ENSMUSG00000055795Mus musculus
 PpiaENSMUSG00000071866Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PPIAL4C / A0A0B4J2A2 / peptidylprolyl isomerase A like 4CENSG0000026346486
Q9Y536 / PPIAL4A / peptidylprolyl isomerase A like 4AENSG0000026335385
PPIAL4E / A0A075B759 / peptidylprolyl isomerase A like 4EENSG0000027156784
F5H284 / PPIAL4D / peptidylprolyl isomerase A like 4DENSG0000025637484
AC243756.1ENSG0000027033984
P0DN26 / PPIAL4F / peptidylprolyl isomerase A like 4FENSG0000027978284
P0DN37 / PPIAL4G / peptidylprolyl isomerase A like 4GENSG0000023633484
PPIF / P30405 / peptidylprolyl isomerase FENSG0000010817975
P49792 / RANBP2 / RAN binding protein 2ENSG0000015320167
PPIE / Q9UNP9 / peptidylprolyl isomerase EENSG0000008407266
RGPD2 / P0DJD1 / RANBP2-like and GRIP domain containing 2ENSG0000018530414
RGPD1 / P0DJD0 / RANBP2-like and GRIP domain containing 1ENSG0000018762714
RGPD8 / O14715 / RANBP2-like and GRIP domain containing 8ENSG0000016962913
RGPD6 / Q99666 / RANBP2-like and GRIP domain containing 6ENSG0000018305413
RGPD5 / Q99666 / RANBP2-like and GRIP domain containing 5ENSG0000001556813
RGPD4 / Q7Z3J3 / RANBP2-like and GRIP domain containing 4ENSG0000019686212
RGPD3 / A6NKT7 / RANBP2-like and GRIP domain containing 3ENSG0000015316512


Protein motifs (from Interpro)
Interpro ID Name
 IPR002130  Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
 IPR020892  Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
 IPR024936  Cyclophilin-type peptidyl-prolyl cis-trans isomerase
 IPR029000  Cyclophilin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000413 protein peptidyl-prolyl isomerization IDA
 biological_processGO:0006278 RNA-dependent DNA biosynthetic process TAS
 biological_processGO:0006457 protein folding TAS
 biological_processGO:0016032 viral process IEA
 biological_processGO:0019058 viral life cycle TAS
 biological_processGO:0019061 uncoating of virus TAS
 biological_processGO:0019064 fusion of virus membrane with host plasma membrane TAS
 biological_processGO:0019068 virion assembly TAS
 biological_processGO:0019076 viral release from host cell TAS
 biological_processGO:0030260 entry into host cell TAS
 biological_processGO:0034389 lipid particle organization IMP
 biological_processGO:0035722 interleukin-12-mediated signaling pathway TAS
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0045069 regulation of viral genome replication TAS
 biological_processGO:0045070 positive regulation of viral genome replication IMP
 biological_processGO:0050714 positive regulation of protein secretion IMP
 biological_processGO:0050900 leukocyte migration TAS
 biological_processGO:0075713 establishment of integrated proviral latency TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space HDA
 cellular_componentGO:0005634 nucleus HDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0031982 vesicle HDA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0034774 secretory granule lumen TAS
 cellular_componentGO:0070062 extracellular exosome TAS
 cellular_componentGO:1904813 ficolin-1-rich granule lumen TAS
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0003755 peptidyl-prolyl cis-trans isomerase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016018 cyclosporin A binding IDA
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0046790 virion binding NAS
 molecular_functionGO:0051082 unfolded protein binding TAS


Pathways (from Reactome)
Pathway description
Platelet degranulation
Uncoating of the HIV Virion
Budding and maturation of HIV virion
Integration of provirus
Early Phase of HIV Life Cycle
Minus-strand DNA synthesis
Plus-strand DNA synthesis
Binding and entry of HIV virion
Assembly Of The HIV Virion
APOBEC3G mediated resistance to HIV-1 infection
Calcineurin activates NFAT
Basigin interactions
Neutrophil degranulation
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000172270 BSG / P35613 / basigin (Ok blood group)  / reaction / complex






 

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