ENSMUSG00000003226


Mus musculus

Features
Gene ID: ENSMUSG00000003226
  
Biological name :Ranbp2
  
Synonyms : E3 SUMO-protein ligase RanBP2 / Q9ERU9 / Ranbp2
  
Possible biological names infered from orthology : A6NKT7 / O14715 / P0DJD0 / P0DJD1 / P49792 / Q7Z3J3 / Q99666 / RAN binding protein 2 / RANBP2-like and GRIP domain containing 1 / RANBP2-like and GRIP domain containing 2 / RANBP2-like and GRIP domain containing 3 / RANBP2-like and GRIP domain containing 4 / RANBP2-like and GRIP domain containing 5 / RANBP2-like and GRIP domain containing 6 / RANBP2-like and GRIP domain containing 8 / RGPD1 / RGPD2 / RGPD3 / RGPD4 / RGPD5 / RGPD6 / RGPD8
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: B4
Gene start: 58446920
Gene end: 58494356
  
Corresponding Affymetrix probe sets: 10363281 (MoGene1.0st)   1422621_at (Mouse Genome 430 2.0 Array)   1440104_at (Mouse Genome 430 2.0 Array)   1445883_at (Mouse Genome 430 2.0 Array)   1450690_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000003310
NCBI entrez gene - 19386     See in Manteia.
MGI - MGI:894323
RefSeq - NM_011240
RefSeq Peptide - NP_035370
swissprot - Q9ERU9
Ensembl - ENSMUSG00000003226
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RANBP2ENSDARG00000093125Danio rerio
 ENSGALG00000016808Gallus gallus
 P49792ENSG00000153201Homo sapiens
 RGPD1ENSG00000187627Homo sapiens
 RGPD2ENSG00000185304Homo sapiens
 RGPD3ENSG00000153165Homo sapiens
 RGPD4ENSG00000196862Homo sapiens
 RGPD5ENSG00000015568Homo sapiens
 RGPD6ENSG00000183054Homo sapiens
 RGPD8ENSG00000169629Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ppif / Q99KR7 / Peptidyl-prolyl cis-trans isomerase F, mitochondrial / P30405* / peptidylprolyl isomerase F*ENSMUSG000000218684
Ppie / Q9QZH3 / Peptidyl-prolyl cis-trans isomerase E / Q9UNP9* / peptidylprolyl isomerase E*ENSMUSG000000286514
Ppia / P17742 / peptidylprolyl isomerase A / P62937*ENSMUSG000000718664
Gm5160 / PPIA* / P62937* / peptidylprolyl isomerase A*ENSMUSG000000557953
Gm12728ENSMUSG000000837801


Protein motifs (from Interpro)
Interpro ID Name
 IPR000156  Ran binding domain
 IPR001876  Zinc finger, RanBP2-type
 IPR002130  Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR011993  PH-like domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR019734  Tetratricopeptide repeat
 IPR020892  Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
 IPR022011  Nup358/RanBP2 E3 ligase domain
 IPR029000  Cyclophilin-like domain superfamily
 IPR036443  Zinc finger, RanBP2-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IBA
 biological_processGO:0000413 protein peptidyl-prolyl isomerization IEA
 biological_processGO:0001975 response to amphetamine IEA
 biological_processGO:0006405 RNA export from nucleus IBA
 biological_processGO:0006457 protein folding IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0006606 protein import into nucleus IBA
 biological_processGO:0007051 spindle organization IBA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016925 protein sumoylation ISS
 biological_processGO:0033133 positive regulation of glucokinase activity IDA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0046604 positive regulation of mitotic centrosome separation IBA
 biological_processGO:0046907 intracellular transport IEA
 biological_processGO:0051028 mRNA transport IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005635 nuclear envelope TAS
 cellular_componentGO:0005642 annulate lamellae ISS
 cellular_componentGO:0005643 nuclear pore ISS
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005813 centrosome IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031965 nuclear membrane ISS
 cellular_componentGO:0042405 nuclear inclusion body ISS
 cellular_componentGO:0044614 nuclear pore cytoplasmic filaments IEA
 cellular_componentGO:0044615 nuclear pore nuclear basket ISS
 cellular_componentGO:1990723 cytoplasmic periphery of the nuclear pore complex IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003755 peptidyl-prolyl cis-trans isomerase activity IEA
 molecular_functionGO:0005096 GTPase activator activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008536 Ran GTPase binding IBA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019789 SUMO transferase activity EXP
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Transport of Mature mRNA derived from an Intron-Containing Transcript
Regulation of Glucokinase by Glucokinase Regulatory Protein
snRNP Assembly
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
SUMOylation of DNA damage response and repair proteins
SUMOylation of ubiquitinylation proteins
Nuclear Pore Complex (NPC) Disassembly
Regulation of HSF1-mediated heat shock response
SUMOylation of SUMOylation proteins
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
Transcriptional regulation by small RNAs
RHO GTPases Activate Formins
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Aw-J/Aw-J
Genetic Background: C57BL/6J-Aw-J/J

Allelic Composition: Ranbp2tm1Jvd/Ranbp2tm1Jvd
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
Show

Allelic Composition: Aw-J/Aw-J
Genetic Background: C57BL/6J-Aw-J/J

Allelic Composition: Ranbp2tm1Jvd/Ranbp2tm1Jvd
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Aw-J/Aw-J
Genetic Background: C57BL/6J-Aw-J/J

Allelic Composition: Ranbp2tm1Jvd/Ranbp2tm1Jvd
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003633 abnormal nervous system physiology 
Show

Allelic Composition: Pax2tm1Mbu/Pax2tm1Mbu
Genetic Background: C3.129P2-Pax2tm1Mbu

 MP:0003701 elevated level of sister chromatid exchange "increased number of crossovers between sister chromatids during meiosis resulting in increased numbers of reciprocal exchanges of DNA between the two chromosomes" [hdene:Howard Dene , Mouse Genome Informatics Curator, J:97667]
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Allelic Composition: Aw-J/Aw-J
Genetic Background: C57BL/6J-Aw-J/J

Allelic Composition: Ranbp2tm1Jvd/Ranbp2tm1Jvd
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pax2tm1Mbu/Pax2tm1Mbu
Genetic Background: C3.129P2-Pax2tm1Mbu

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Aw-J/Aw-J
Genetic Background: C57BL/6J-Aw-J/J

Allelic Composition: Ranbp2tm1Jvd/Ranbp2tm1.1Jvd
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ranbp2tm1Jvd/Ranbp2tm1Jvd
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ranbp2tm1Jvd/Ranbp2tm1.1Jvd
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ranbp2tm1Jvd/Ranbp2tm1Jvd
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ranbp2tm1Jvd/Ranbp2tm1.1Jvd
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ranbp2tm1Jvd/Ranbp2tm1Jvd
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pax2tm1Mbu/Pax2tm1Mbu
Genetic Background: C3.129P2-Pax2tm1Mbu

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Pax2tm1Mbu/Pax2tm1Mbu
Genetic Background: C3.129P2-Pax2tm1Mbu

 MP:0008714 lung carcinoma "a malignant neoplasm of the ling, arising from epithelial cells, usually glandular or squamous" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ranbp2tm1Jvd/Ranbp2tm1.1Jvd
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ranbp2tm1Jvd/Ranbp2tm1Jvd
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0010308 decreased tumor latency "earlier onset of tumor occurrence than expected" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ranbp2tm1Jvd/Ranbp2tm1.1Jvd
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ranbp2tm1Jvd/Ranbp2tm1Jvd
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Pax2tm1Mbu/Pax2tm1Mbu
Genetic Background: C3.129P2-Pax2tm1Mbu

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Aw-J/Aw-J
Genetic Background: C57BL/6J-Aw-J/J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Rad21ltm1b(KOMP)Wtsi/Rad21ltm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad21ltm1b(KOMP)Wtsi/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / complex / reaction
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / reaction / complex
 ENSMUSG00000022391 P46061 / Rangap1 / Ran GTPase-activating protein 1 / P46060*  / complex






 

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