ENSMUSG00000022391


Mus musculus

Features
Gene ID: ENSMUSG00000022391
  
Biological name :Rangap1
  
Synonyms : P46061 / Rangap1 / Ran GTPase-activating protein 1
  
Possible biological names infered from orthology : P46060
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: E1
Gene start: 81704248
Gene end: 81745530
  
Corresponding Affymetrix probe sets: 10430748 (MoGene1.0st)   1423749_s_at (Mouse Genome 430 2.0 Array)   1444581_at (Mouse Genome 430 2.0 Array)   1451092_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000130046
Ensembl peptide - ENSMUSP00000126849
Ensembl peptide - ENSMUSP00000155198
Ensembl peptide - ENSMUSP00000155851
Ensembl peptide - ENSMUSP00000057771
NCBI entrez gene - 19387     See in Manteia.
MGI - MGI:103071
RefSeq - XM_011245524
RefSeq - NM_001146174
RefSeq - NM_011241
RefSeq - XM_006520646
RefSeq Peptide - NP_001139646
RefSeq Peptide - NP_035371
swissprot - P46061
Ensembl - ENSMUSG00000022391
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rangap1aENSDARG00000041317Danio rerio
 rangap1bENSDARG00000056059Danio rerio
 RANGAP1ENSGALG00000011966Gallus gallus
 P46060ENSG00000100401Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR009109  Ran-GTPase activating protein 1, C-terminal
 IPR027038  Ran GTPase-activating protein
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036720  Ran-GTPase activating protein 1, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0046826 negative regulation of protein export from nucleus ISO
 biological_processGO:0048678 response to axon injury IEA
 biological_processGO:0071375 cellular response to peptide hormone stimulus IEA
 biological_processGO:0090630 activation of GTPase activity IEA
 biological_processGO:1904117 cellular response to vasopressin IEA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore ISO
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope ISO
 cellular_componentGO:0005643 nuclear pore IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016235 aggresome ISO
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 cellular_componentGO:0044614 nuclear pore cytoplasmic filaments IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISO
 cellular_componentGO:0072686 mitotic spindle IEA
 cellular_componentGO:1904115 axon cytoplasm IEA
 cellular_componentGO:1990723 cytoplasmic periphery of the nuclear pore complex IEA
 molecular_functionGO:0003723 RNA binding ISO
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008536 Ran GTPase binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0045296 cadherin binding ISO


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
SUMOylation of DNA replication proteins
RHO GTPases Activate Formins
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdh23Ahl+/Cdh23Ahl+,Ush2atm1Tili/Ush2atm1Tili
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CAST/EiJ * CBA/CaJ

 MP:0001680 abnormal mesoderm development "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdh23Ahl+/Cdh23Ahl+,Ush2atm1Tili/Ush2atm1Tili
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CAST/EiJ * CBA/CaJ

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Cdh23Ahl+/Cdh23Ahl+,Ush2atm1Tili/Ush2atm1Tili
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CAST/EiJ * CBA/CaJ

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Cdh23Ahl+/Cdh23Ahl+,Ush2atm1Tili/Ush2atm1Tili
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CAST/EiJ * CBA/CaJ

 MP:0003886 abnormal embryonic epiblast morphology "anomaly in the development/organization of the tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdh23Ahl+/Cdh23Ahl+,Ush2atm1Tili/Ush2atm1Tili
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CAST/EiJ * CBA/CaJ

 MP:0005032 abnormal ectoplacental cone 
Show

Allelic Composition: Cdh23Ahl+/Cdh23Ahl+,Ush2atm1Tili/Ush2atm1Tili
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CAST/EiJ * CBA/CaJ

 MP:0011106 partial embryonic lethality before somite formation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Cdh23Ahl+/Cdh23Ahl+,Ush2atm1Tili/Ush2atm1Tili
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CAST/EiJ * CBA/CaJ

 MP:0011200 abnormal extraembryonic coelom morphology "any structural anomaly of the fluid-filled spaces formed within the mass of extraembryonic mesoderm that later fuse to become a large extraembryonic cavity" [ISBN:0-12-402035-6, ISBN-10:1405118660]
Show

Allelic Composition: Cdh23Ahl+/Cdh23Ahl+,Ush2atm1Tili/Ush2atm1Tili
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CAST/EiJ * CBA/CaJ

 MP:0011207 absent ectoplacental cavity "absence of the closed space within the ectoplacental cone, formed by the fusion of the parts of the amniotic fold that separate it from the amniotic cavity" [ISBN:0-12-402035-6]
Show

Allelic Composition: Cdh23Ahl+/Cdh23Ahl+,Ush2atm1Tili/Ush2atm1Tili
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CAST/EiJ * CBA/CaJ

 MP:0011208 small proamniotic cavity "reduced size of the cavity of the developing embryo that is formed within the epiblast tissue prior to the closing of the proamniotic canal by the amniotic folds" [ISBN:0-12-402035-6]
Show

Allelic Composition: Cdh23Ahl+/Cdh23Ahl+,Ush2atm1Tili/Ush2atm1Tili
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CAST/EiJ * CBA/CaJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003226 Q9ERU9 / Ranbp2 / E3 SUMO-protein ligase RanBP2 / RGPD3* / RGPD2* / RGPD1* / RGPD8* / RGPD6* / RGPD5* / RGPD4* / A6NKT7* / O14715* / P0DJD0* / P0DJD1* / P49792* / Q7Z3J3* / Q99666* / RAN b...  / complex
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / complex
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / complex






 

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