ENSG00000100401


Homo sapiens

Features
Gene ID: ENSG00000100401
  
Biological name :RANGAP1
  
Synonyms : P46060 / RANGAP1 / Ran GTPase activating protein 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: -1
Band: q13.2
Gene start: 41245611
Gene end: 41286251
  
Corresponding Affymetrix probe sets: 1553535_a_at (Human Genome U133 Plus 2.0 Array)   212125_at (Human Genome U133 Plus 2.0 Array)   212127_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000393407
Ensembl peptide - ENSP00000385866
Ensembl peptide - ENSP00000394787
Ensembl peptide - ENSP00000408743
Ensembl peptide - ENSP00000404842
Ensembl peptide - ENSP00000401470
Ensembl peptide - ENSP00000348577
NCBI entrez gene - 5905     See in Manteia.
OMIM - 602362
RefSeq - XM_017028899
RefSeq - XM_011530293
RefSeq - XM_011530294
RefSeq - XM_011530295
RefSeq - XM_017028893
RefSeq - XM_017028894
RefSeq - XM_017028895
RefSeq - XM_017028896
RefSeq - XM_017028897
RefSeq - XM_017028898
RefSeq - NM_001278651
RefSeq - NM_001317930
RefSeq - NM_002883
RefSeq - XM_005261695
RefSeq - XM_005261696
RefSeq - XM_006724289
RefSeq Peptide - NP_001304859
RefSeq Peptide - NP_002874
RefSeq Peptide - NP_001265580
swissprot - H0Y4Q3
swissprot - B0QYT6
swissprot - P46060
swissprot - A0A024R1U0
swissprot - B0QYT5
swissprot - B0QYT4
Ensembl - ENSG00000100401
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rangap1aENSDARG00000041317Danio rerio
 rangap1bENSDARG00000056059Danio rerio
 RANGAP1ENSGALG00000011966Gallus gallus
 P46061ENSMUSG00000022391Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR009109  Ran-GTPase activating protein 1, C-terminal
 IPR027038  Ran GTPase-activating protein
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036720  Ran-GTPase activating protein 1, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007062 sister chromatid cohesion TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0016925 protein sumoylation TAS
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0046826 negative regulation of protein export from nucleus IDA
 biological_processGO:0048678 response to axon injury IEA
 biological_processGO:0071375 cellular response to peptide hormone stimulus IEA
 biological_processGO:0090630 activation of GTPase activity IDA
 biological_processGO:1904117 cellular response to vasopressin IEA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope TAS
 cellular_componentGO:0005643 nuclear pore TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016235 aggresome IDA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031965 nuclear membrane IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0044614 nuclear pore cytoplasmic filaments IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0072686 mitotic spindle IEA
 cellular_componentGO:1904115 axon cytoplasm IEA
 cellular_componentGO:1990723 cytoplasmic periphery of the nuclear pore complex IEA
 molecular_functionGO:0003723 RNA binding IDA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008536 Ran GTPase binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0045296 cadherin binding IDA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Rev-mediated nuclear export of HIV RNA
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
SUMOylation of DNA replication proteins
RHO GTPases Activate Formins
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / complex
 ENSG00000153201 P49792 / RANBP2 / RAN binding protein 2  / complex
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / complex






 

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