ENSMUSG00000026576


Mus musculus

Features
Gene ID: ENSMUSG00000026576
  
Biological name :Atp1b1
  
Synonyms : Atp1b1 / P14094 / Sodium/potassium-transporting ATPase subunit beta-1
  
Possible biological names infered from orthology : ATPase Na+/K+ transporting subunit beta 1 / P05026
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H2.2
Gene start: 164437109
Gene end: 164458355
  
Corresponding Affymetrix probe sets: 10359689 (MoGene1.0st)   1418453_a_at (Mouse Genome 430 2.0 Array)   1423890_x_at (Mouse Genome 430 2.0 Array)   1439036_a_at (Mouse Genome 430 2.0 Array)   1451152_a_at (Mouse Genome 430 2.0 Array)   1455949_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141777
Ensembl peptide - ENSMUSP00000027863
NCBI entrez gene - 11931     See in Manteia.
MGI - MGI:88108
RefSeq - NM_009721
RefSeq Peptide - NP_033851
swissprot - A0A0A6YX05
swissprot - P14094
swissprot - Q545P0
Ensembl - ENSMUSG00000026576
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atp1b1aENSDARG00000013144Danio rerio
 atp1b1bENSDARG00000076833Danio rerio
 ATP1B1ENSGALG00000015233Gallus gallus
 ATP1B1ENSG00000143153Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Atp1b2 / P14231 / Sodium/potassium-transporting ATPase subunit beta-2 / P14415* / ATPase Na+/K+ transporting subunit beta 2*ENSMUSG0000004132937
Atp1b4 / Q99ME6 / Protein ATP1B4 / Q9UN42* / ATPase Na+/K+ transporting family member beta 4*ENSMUSG0000001632732
Atp1b3 / P97370 / Sodium/potassium-transporting ATPase subunit beta-3 / P54709* / ATPase Na+/K+ transporting subunit beta 3*ENSMUSG0000003241231
Atp4b / P50992 / Potassium-transporting ATPase subunit beta / P51164* / ATPase H+/K+ transporting beta subunit*ENSMUSG0000003144929


Protein motifs (from Interpro)
Interpro ID Name
 IPR000402  Sodium/potassium-transporting ATPase subunit beta
 IPR015565  Sodium/potassium-transporting ATPase subunit beta, chordates


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IMP
 biological_processGO:0006883 cellular sodium ion homeostasis IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0010107 potassium ion import IC
 biological_processGO:0010248 establishment or maintenance of transmembrane electrochemical gradient IEA
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0010882 regulation of cardiac muscle contraction by calcium ion signaling IMP
 biological_processGO:0030001 metal ion transport IEA
 biological_processGO:0030007 cellular potassium ion homeostasis IEA
 biological_processGO:0032781 positive regulation of ATPase activity IEA
 biological_processGO:0036376 sodium ion export across plasma membrane IC
 biological_processGO:0046034 ATP metabolic process IEA
 biological_processGO:0050821 protein stabilization IMP
 biological_processGO:0055119 relaxation of cardiac muscle IMP
 biological_processGO:0060048 cardiac muscle contraction IMP
 biological_processGO:0072659 protein localization to plasma membrane IEA
 biological_processGO:0086009 membrane repolarization IEA
 biological_processGO:1901018 positive regulation of potassium ion transmembrane transporter activity IEA
 biological_processGO:1903169 regulation of calcium ion transmembrane transport IMP
 biological_processGO:1903278 positive regulation of sodium ion export across plasma membrane IEA
 biological_processGO:1903281 positive regulation of calcium:sodium antiporter activity IMP
 biological_processGO:1903288 positive regulation of potassium ion import IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005890 sodium:potassium-exchanging ATPase complex IEA
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0014704 intercalated disc IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0042383 sarcolemma IMP
 cellular_componentGO:0043209 myelin sheath IDA
 molecular_functionGO:0001671 ATPase activator activity IEA
 molecular_functionGO:0005391 sodium:potassium-exchanging ATPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IPI
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0030955 potassium ion binding IEA
 molecular_functionGO:0031402 sodium ion binding IEA
 molecular_functionGO:0051117 ATPase binding IEA


Pathways (from Reactome)
Pathway description
Basigin interactions
Ion homeostasis
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Faslpr/Faslpr,Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: MRL.Cg-Fcer1gtm1Tks Faslpr

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Faslpr/Faslpr,Fcer1gtm1Tks/Fcer1gtm1Tks
Genetic Background: MRL.Cg-Fcer1gtm1Tks Faslpr

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Atp1b1tm1.1Akra/Atp1b1tm1.1Akra,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

 MP:0002972 abnormal cardiac muscle contractility "altered ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Atp1b1tm1.1Akra/Atp1b1tm1.1Akra,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atp1b1tm1.1Akra/Atp1b1tm1.1Akra,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

 MP:0004485 increased response of heart to induced stress "increase in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atp1b1tm1.1Akra/Atp1b1tm1.1Akra,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Atp1b1tm1.1Akra/Atp1b1tm1.1Akra,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atp1b1tm1.1Akra/Atp1b1tm1.1Akra,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atp1b1tm1.1Akra/Atp1b1tm1.1Akra,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Cacna1atg/Cacna1atg,Tg(Pcp2-TAg)4Horr/0
Genetic Background: B6J.Cg-Cacna1atg Tg(Pcp2-TAg)4Horr

 MP:0014026 abnormal respiratory epithelial transmembrane transport "any anomaly in the directed movement of a substance from one side of the respiratory epithelial cell membrane to the other" [MGI:csmith]
Show

Allelic Composition: Cacna1atg/Cacna1atg,Tg(Pcp2-TAg)4Horr/0
Genetic Background: B6J.Cg-Cacna1atg Tg(Pcp2-TAg)4Horr

Allelic Composition: Atp1b1tm1.1Zboro/Atp1b1tm1.1Zboro,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0014181 abnormal respiratory epithelial sodium ion transmembrane transport "any anomaly in the directed movement of a sodium from one side of the respiratory epithelial cell membrane to the other" [GO:0035725]
Show

Allelic Composition: Atp1b1tm1.1Zboro/Atp1b1tm1.1Zboro,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000007107 Atp1a4 / Q9WV27 / Sodium/potassium-transporting ATPase subunit alpha-4 / Q13733* / ATPase Na+/K+ transporting subunit alpha 4*  / complex
 ENSMUSG00000007097 Atp1a2 / Q6PIE5 / Sodium/potassium-transporting ATPase subunit alpha-2 / P50993* / ATPase Na+/K+ transporting subunit alpha 2*  / complex
 ENSMUSG00000040907 Atp1a3 / Q6PIC6 / Sodium/potassium-transporting ATPase subunit alpha-3 / P13637* / AC010616.2* / ATPase Na+/K+ transporting subunit alpha 3*  / complex
 ENSMUSG00000041329 Atp1b2 / P14231 / Sodium/potassium-transporting ATPase subunit beta-2 / P14415* / ATPase Na+/K+ transporting subunit beta 2*  / complex
 ENSMUSG00000033161 Atp1a1 / Q8VDN2 / Sodium/potassium-transporting ATPase subunit alpha-1 / P05023* / ATPase Na+/K+ transporting subunit alpha 1*  / complex
 ENSMUSG00000032412 Atp1b3 / P97370 / Sodium/potassium-transporting ATPase subunit beta-3 / P54709* / ATPase Na+/K+ transporting subunit beta 3*  / complex
 ENSMUSG00000023175 Bsg / P18572 / Basigin / P35613* / basigin (Ok blood group)*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr