ENSMUSG00000033161


Mus musculus

Features
Gene ID: ENSMUSG00000033161
  
Biological name :Atp1a1
  
Synonyms : Atp1a1 / Q8VDN2 / Sodium/potassium-transporting ATPase subunit alpha-1
  
Possible biological names infered from orthology : ATPase Na+/K+ transporting subunit alpha 1 / P05023
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F2.2
Gene start: 101576219
Gene end: 101604684
  
Corresponding Affymetrix probe sets: 10500685 (MoGene1.0st)   1423653_at (Mouse Genome 430 2.0 Array)   1451071_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000039657
NCBI entrez gene - 11928     See in Manteia.
MGI - MGI:88105
RefSeq - NM_144900
RefSeq Peptide - NP_659149
swissprot - Q8VDN2
Ensembl - ENSMUSG00000033161
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atp1a1a.1ENSDARG00000002791Danio rerio
 atp1a1a.2ENSDARG00000007739Danio rerio
 atp1a1a.3ENSDARG00000039131Danio rerio
 atp1a1a.4ENSDARG00000001870Danio rerio
 atp1a1a.5ENSDARG00000040252Danio rerio
 atp1a1bENSDARG00000019856Danio rerio
 ATP1A1ENSGALG00000032247Gallus gallus
 ATP1A1ENSG00000163399Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Atp1a2 / Q6PIE5 / Sodium/potassium-transporting ATPase subunit alpha-2 / P50993* / ATPase Na+/K+ transporting subunit alpha 2*ENSMUSG0000000709787
Atp1a3 / Q6PIC6 / Sodium/potassium-transporting ATPase subunit alpha-3 / P13637* / AC010616.2* / ATPase Na+/K+ transporting subunit alpha 3*ENSMUSG0000004090785
Atp1a4 / Q9WV27 / Sodium/potassium-transporting ATPase subunit alpha-4 / Q13733* / ATPase Na+/K+ transporting subunit alpha 4*ENSMUSG0000000710778
Atp12a / Q9Z1W8 / Potassium-transporting ATPase alpha chain 2 / P54707* / ATPase H+/K+ transporting non-gastric alpha2 subunit*ENSMUSG0000002222964
Atp4a / ATPase H+/K+ transporting alpha subunit / P20648*ENSMUSG0000000555362
Atp2a3 / Q64518 / Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 / Q93084* / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3*ENSMUSG0000002078829
Atp2a2 / O55143 / Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 / P16615* / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2*ENSMUSG0000002946728
Atp2a1 / Q8R429 / Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 / O14983* / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1*ENSMUSG0000003073028
A7L9Z8 / Atp2c2 / Calcium-transporting ATPase type 2C member 2 / O75185* / ATPase secretory pathway Ca2+ transporting 2*ENSMUSG0000003411227
Atp2c1 / Q80XR2 / Calcium-transporting ATPase type 2C member 1 / P98194* / ATPase secretory pathway Ca2+ transporting 1*ENSMUSG0000003257027


Protein motifs (from Interpro)
Interpro ID Name
 IPR001757  P-type ATPase
 IPR004014  Cation-transporting P-type ATPase, N-terminal
 IPR005775  P-type ATPase subfamily IIC, subunit alpha
 IPR006068  Cation-transporting P-type ATPase, C-terminal
 IPR008250  P-type ATPase, A domain superfamily
 IPR018303  P-type ATPase, phosphorylation site
 IPR023298  P-type ATPase, transmembrane domain superfamily
 IPR023299  P-type ATPase, cytoplasmic domain N
 IPR036412  HAD-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002026 regulation of the force of heart contraction IMP
 biological_processGO:0002028 regulation of sodium ion transport IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0006883 cellular sodium ion homeostasis IEA
 biological_processGO:0008217 regulation of blood pressure IGI
 biological_processGO:0010107 potassium ion import IEA
 biological_processGO:0010248 establishment or maintenance of transmembrane electrochemical gradient IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0030007 cellular potassium ion homeostasis IEA
 biological_processGO:0031947 negative regulation of glucocorticoid biosynthetic process IMP
 biological_processGO:0036376 sodium ion export across plasma membrane IEA
 biological_processGO:0042493 response to drug IMP
 biological_processGO:0045822 negative regulation of heart contraction IMP
 biological_processGO:0045823 positive regulation of heart contraction IMP
 biological_processGO:0045989 positive regulation of striated muscle contraction IMP
 biological_processGO:0060081 membrane hyperpolarization IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0071383 cellular response to steroid hormone stimulus IEA
 biological_processGO:0086004 regulation of cardiac muscle cell contraction IEA
 biological_processGO:0086009 membrane repolarization IEA
 biological_processGO:0090662 ATP hydrolysis coupled transmembrane transport IEA
 biological_processGO:1990573 potassium ion import across plasma membrane IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005890 sodium:potassium-exchanging ATPase complex IEA
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0014704 intercalated disc IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane ISS
 cellular_componentGO:0016323 basolateral plasma membrane IDA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0030315 T-tubule IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0042383 sarcolemma IEA
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005391 sodium:potassium-exchanging ATPase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IMP
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0030506 ankyrin binding IEA
 molecular_functionGO:0030955 potassium ion binding IEA
 molecular_functionGO:0031402 sodium ion binding IEA
 molecular_functionGO:0043531 ADP binding IEA
 molecular_functionGO:0043548 phosphatidylinositol 3-kinase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051087 chaperone binding IEA
 molecular_functionGO:1990239 steroid hormone binding IEA


Pathways (from Reactome)
Pathway description
Ion homeostasis
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000738 impaired muscle contractility "inability or reduced ability of a muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mfge8tm1Osa/Mfge8tm1Osa
Genetic Background: B6.129-Mfge8tm1Osa

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Atp1a1Gt(OST31117)Lex/Atp1a1Gt(OST31117)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
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Allelic Composition: Atp1a1Gt(OST31117)Lex/Atp1a1Gt(OST31117)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001745 increased circulating corticosterone level "greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
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Allelic Composition: Dkk1tm1Lmgd/Dkk1tm1Lmgd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dkk1tm1Lmgd/Dkk1tm1Lmgd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Juntm4Wag/Juntm4Wag,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0005599 increased cardiac muscle contractility "greater than the normal ability of the heart muscle to shorten or to develop increased tension " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,Plautm1Mlg/Plautm1Mlg
Genetic Background: involves: 129 * C57BL/6

 MP:0009749 enhanced behavioral response to addictive substance "increased sensitivity to an addictive substance capable of inducing the appearance of behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dkk1tm1Lmgd/Dkk1tm1Lmgd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Juntm4Wag/Juntm4Wag,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Atp1a1Gt(OST31117)Lex/Atp1a1Gt(OST31117)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026576 Atp1b1 / P14094 / Sodium/potassium-transporting ATPase subunit beta-1 / P05026* / ATPase Na+/K+ transporting subunit beta 1*  / complex
 ENSMUSG00000032412 Atp1b3 / P97370 / Sodium/potassium-transporting ATPase subunit beta-3 / P54709* / ATPase Na+/K+ transporting subunit beta 3*  / complex
 ENSMUSG00000041329 Atp1b2 / P14231 / Sodium/potassium-transporting ATPase subunit beta-2 / P14415* / ATPase Na+/K+ transporting subunit beta 2*  / complex






 

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