ENSMUSG00000022229


Mus musculus

Features
Gene ID: ENSMUSG00000022229
  
Biological name :Atp12a
  
Synonyms : Atp12a / Potassium-transporting ATPase alpha chain 2 / Q9Z1W8
  
Possible biological names infered from orthology : ATPase H+/K+ transporting non-gastric alpha2 subunit / P54707
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: C3
Gene start: 56365068
Gene end: 56388550
  
Corresponding Affymetrix probe sets: 10415446 (MoGene1.0st)   1449475_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000007340
NCBI entrez gene - 192113     See in Manteia.
MGI - MGI:1926943
RefSeq - NM_138652
RefSeq Peptide - NP_619593
swissprot - Q9Z1W8
Ensembl - ENSMUSG00000022229
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ATP12AENSGALG00000006469Gallus gallus
 ATP12AENSG00000075673Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Atp1a2 / Q6PIE5 / Sodium/potassium-transporting ATPase subunit alpha-2 / P50993* / ATPase Na+/K+ transporting subunit alpha 2*ENSMUSG0000000709764
Atp1a3 / Q6PIC6 / Sodium/potassium-transporting ATPase subunit alpha-3 / P13637* / AC010616.2* / ATPase Na+/K+ transporting subunit alpha 3*ENSMUSG0000004090764
Atp4a / ATPase H+/K+ transporting alpha subunit / P20648*ENSMUSG0000000555363
Atp1a1 / Q8VDN2 / Sodium/potassium-transporting ATPase subunit alpha-1 / P05023* / ATPase Na+/K+ transporting subunit alpha 1*ENSMUSG0000003316163
Atp1a4 / Q9WV27 / Sodium/potassium-transporting ATPase subunit alpha-4 / Q13733* / ATPase Na+/K+ transporting subunit alpha 4*ENSMUSG0000000710761
Atp2a1 / Q8R429 / Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 / O14983* / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1*ENSMUSG0000003073027
Atp2a3 / Q64518 / Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 / Q93084* / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3*ENSMUSG0000002078827
Atp2a2 / O55143 / Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 / P16615* / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2*ENSMUSG0000002946727
Atp2c1 / Q80XR2 / Calcium-transporting ATPase type 2C member 1 / P98194* / ATPase secretory pathway Ca2+ transporting 1*ENSMUSG0000003257025
A7L9Z8 / Atp2c2 / Calcium-transporting ATPase type 2C member 2 / O75185* / ATPase secretory pathway Ca2+ transporting 2*ENSMUSG0000003411225


Protein motifs (from Interpro)
Interpro ID Name
 IPR001757  P-type ATPase
 IPR004014  Cation-transporting P-type ATPase, N-terminal
 IPR005775  P-type ATPase subfamily IIC, subunit alpha
 IPR006068  Cation-transporting P-type ATPase, C-terminal
 IPR008250  P-type ATPase, A domain superfamily
 IPR018303  P-type ATPase, phosphorylation site
 IPR023298  P-type ATPase, transmembrane domain superfamily
 IPR023299  P-type ATPase, cytoplasmic domain N
 IPR030318  Potassium-transporting ATPase alpha chain 2
 IPR036412  HAD-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0006885 regulation of pH IMP
 biological_processGO:0010248 establishment or maintenance of transmembrane electrochemical gradient IEA
 biological_processGO:0055075 potassium ion homeostasis IMP
 biological_processGO:0099132 ATP hydrolysis coupled cation transmembrane transport IEA
 biological_processGO:1902600 proton transmembrane transport IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IMP
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005391 sodium:potassium-exchanging ATPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008900 potassium:proton exchanging ATPase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019829 cation-transporting ATPase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003866 abnormal defecation "anomaly in the production and excretion of feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0005619 increased potassium excretion "greater than the normal amount of this alkaline metallic element, the most abundant intracellular ion, voided by the kidneys" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0005628 decreased circulating potassium level "less than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:Rat Genome Database submission]
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Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

 MP:0010180 increased susceptibility to weight loss "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atf1tm1Gsc/Atf1+,Creb1tm2Gsc/Creb1tm2Gsc
Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031449 Atp4b / P50992 / Potassium-transporting ATPase subunit beta / P51164* / ATPase H+/K+ transporting beta subunit*  / complex






 

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