ENSMUSG00000029467


Mus musculus

Features
Gene ID: ENSMUSG00000029467
  
Biological name :Atp2a2
  
Synonyms : Atp2a2 / O55143 / Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
  
Possible biological names infered from orthology : ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 / P16615
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: F
Gene start: 122453513
Gene end: 122502225
  
Corresponding Affymetrix probe sets: 10533483 (MoGene1.0st)   1416551_at (Mouse Genome 430 2.0 Array)   1427250_at (Mouse Genome 430 2.0 Array)   1427251_at (Mouse Genome 430 2.0 Array)   1437797_at (Mouse Genome 430 2.0 Array)   1443551_at (Mouse Genome 430 2.0 Array)   1452363_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000031423
Ensembl peptide - ENSMUSP00000135935
Ensembl peptide - ENSMUSP00000136104
NCBI entrez gene - 11938     See in Manteia.
MGI - MGI:88110
RefSeq - NM_001110140
RefSeq - NM_009722
RefSeq Peptide - NP_001103610
RefSeq Peptide - NP_033852
swissprot - O55143
Ensembl - ENSMUSG00000029467
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atp2a2aENSDARG00000029439Danio rerio
 atp2a2aENSDARG00000005122Danio rerio
 ATP2A2ENSGALG00000032287Gallus gallus
 ATP2A2ENSG00000174437Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Atp2a1 / Q8R429 / Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 / O14983* / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1*ENSMUSG0000003073080
Atp2a3 / Q64518 / Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 / Q93084* / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3*ENSMUSG0000002078874
Atp2c1 / Q80XR2 / Calcium-transporting ATPase type 2C member 1 / P98194* / ATPase secretory pathway Ca2+ transporting 1*ENSMUSG0000003257031
A7L9Z8 / Atp2c2 / Calcium-transporting ATPase type 2C member 2 / O75185* / ATPase secretory pathway Ca2+ transporting 2*ENSMUSG0000003411229
Atp1a4 / Q9WV27 / Sodium/potassium-transporting ATPase subunit alpha-4 / Q13733* / ATPase Na+/K+ transporting subunit alpha 4*ENSMUSG0000000710728
Atp4a / ATPase H+/K+ transporting alpha subunit / P20648*ENSMUSG0000000555328
Atp1a3 / Q6PIC6 / Sodium/potassium-transporting ATPase subunit alpha-3 / P13637* / AC010616.2* / ATPase Na+/K+ transporting subunit alpha 3*ENSMUSG0000004090728
Atp12a / Q9Z1W8 / Potassium-transporting ATPase alpha chain 2 / P54707* / ATPase H+/K+ transporting non-gastric alpha2 subunit*ENSMUSG0000002222927
Atp1a2 / Q6PIE5 / Sodium/potassium-transporting ATPase subunit alpha-2 / P50993* / ATPase Na+/K+ transporting subunit alpha 2*ENSMUSG0000000709727
Atp1a1 / Q8VDN2 / Sodium/potassium-transporting ATPase subunit alpha-1 / P05023* / ATPase Na+/K+ transporting subunit alpha 1*ENSMUSG0000003316127


Protein motifs (from Interpro)
Interpro ID Name
 IPR001757  P-type ATPase
 IPR004014  Cation-transporting P-type ATPase, N-terminal
 IPR005782  P-type ATPase, subfamily IIA, SERCA-type
 IPR006068  Cation-transporting P-type ATPase, C-terminal
 IPR008250  P-type ATPase, A domain superfamily
 IPR018303  P-type ATPase, phosphorylation site
 IPR023214  HAD superfamily
 IPR023298  P-type ATPase, transmembrane domain superfamily
 IPR023299  P-type ATPase, cytoplasmic domain N
 IPR036412  HAD-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002026 regulation of the force of heart contraction IGI
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006874 cellular calcium ion homeostasis ISO
 biological_processGO:0006937 regulation of muscle contraction TAS
 biological_processGO:0006984 ER-nucleus signaling pathway IMP
 biological_processGO:0006996 organelle organization IMP
 biological_processGO:0010882 regulation of cardiac muscle contraction by calcium ion signaling IEA
 biological_processGO:0014883 transition between fast and slow fiber IDA
 biological_processGO:0014898 cardiac muscle hypertrophy in response to stress IDA
 biological_processGO:0032469 endoplasmic reticulum calcium ion homeostasis IEA
 biological_processGO:0032470 positive regulation of endoplasmic reticulum calcium ion concentration IEA
 biological_processGO:0033292 T-tubule organization IMP
 biological_processGO:0034599 cellular response to oxidative stress IGI
 biological_processGO:0045822 negative regulation of heart contraction IGI
 biological_processGO:0055119 relaxation of cardiac muscle IEA
 biological_processGO:0070296 sarcoplasmic reticulum calcium ion transport IMP
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0086036 regulation of cardiac muscle cell membrane potential IEA
 biological_processGO:0098909 regulation of cardiac muscle cell action potential involved in regulation of contraction IEA
 biological_processGO:0099132 ATP hydrolysis coupled cation transmembrane transport IEA
 biological_processGO:1903233 regulation of calcium ion-dependent exocytosis of neurotransmitter IMP
 biological_processGO:1903515 calcium ion transport from cytosol to endoplasmic reticulum IEA
 biological_processGO:1990036 calcium ion import into sarcoplasmic reticulum IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane ISO
 cellular_componentGO:0012506 vesicle membrane IEA
 cellular_componentGO:0014704 intercalated disc ISO
 cellular_componentGO:0014801 longitudinal sarcoplasmic reticulum ISO
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016529 sarcoplasmic reticulum TAS
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IEA
 cellular_componentGO:0033017 sarcoplasmic reticulum membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0090534 calcium ion-transporting ATPase complex ISO
 cellular_componentGO:0097470 ribbon synapse IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005388 calcium-transporting ATPase activity ISO
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008022 protein C-terminus binding ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0031775 lutropin-choriogonadotropic hormone receptor binding IEA
 molecular_functionGO:0044548 S100 protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0086039 calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential IEA


Pathways (from Reactome)
Pathway description
Reduction of cytosolic Ca++ levels
Ion homeostasis
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
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Allelic Composition: H2afytm1Peh/H2afytm1Peh,H2afy2tm1.1Peh/H2afy2tm1.1Peh
Genetic Background: 129S6.Cg-H2afy2tm1.1Peh H2afytm1Peh

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Atp2a2tm1.1Iemr/Atp2a2tm1.1Iemr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0000277 abnormal heart shape "malformation of the form or the patterning of the heart" [J:18048]
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Allelic Composition: Shhtm2Amc/Shhtm3Amc,Tg(Pax2-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129 * FVB/N * Swiss

 MP:0000466 esophageal epithelium hyperplasia "increased cell number in the epithelial layer of the esophagus" [J:47225]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000582 toenail hyperkeratosis "keratin extensions from the toenails" [J:62478]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Shhtm2Amc/Shhtm3Amc,Tg(Pax2-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
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Allelic Composition: Shhtm2Amc/Shhtm3Amc,Tg(Pax2-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Oca2p-un+3J/Oca2p-un+3J
Genetic Background: C57BL/6J-Oca2p-un

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss

Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129 * FVB/N * Swiss

 MP:0001627 abnormal cardiac output "anomaly in the blood volume pumped by each ventricle per minute (stroke volume x heart rate)" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129 * FVB/N * Swiss

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: H2afytm1Peh/H2afytm1Peh,H2afy2tm1.1Peh/H2afy2tm1.1Peh
Genetic Background: 129S6.Cg-H2afy2tm1.1Peh H2afytm1Peh

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm2Amc/Shhtm3Amc,Tg(Pax2-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002051 skin papilloma "a circumscribed, benign epithelial tumor projecting from the surrounding surface" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002067 abnormal sensory capabilities/reflexes/nociception "inability or altered ability to respond to a sensory stimulus" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atp1a3tm1b(EUCOMM)Hmgu/Atp1a3+
Genetic Background: C57BL/6N-Atp1a3tm1b(EUCOMM)Hmgu/H

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129 * FVB/N * Swiss

 MP:0002128 abnormal blood circulation "failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: H2afytm1Peh/H2afytm1Peh,H2afy2tm1.1Peh/H2afy2tm1.1Peh
Genetic Background: 129S6.Cg-H2afy2tm1.1Peh H2afytm1Peh

 MP:0002625 left ventricle hypertrophy "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002754 dilated right ventricle "an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss

Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129 * FVB/N * Swiss

Allelic Composition: Atp2a2tm1Ges/Atp2a2+,Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol/0,Tg(Myh6-tTA)55Rbns/0
Genetic Background: involves: 129X1/SvJ * FVB

Allelic Composition: Atp2a2tm1Ges/Atp2a2+,Tg(Myh6/tetO-Tnnc1*L48Q)2Jmol/0,Tg(Myh6-tTA)55Rbns/0
Genetic Background: involves: 129X1/SvJ * FVB

 MP:0002843 decreased blood pressure "decreased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002899 fatigue "easily exhausted due to mental or physical exertion" [hdene:Howard Dene , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss

 MP:0002953 thick ventricular wall "increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss

Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129 * FVB/N * Swiss

 MP:0003140 dilated atria "an expansion in the volume of one or both of the upper chambers of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Atp2a2tm1.1Iemr/Atp2a2tm1.1Iemr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss

 MP:0003277 esophageal papilloma "benign epithelial tumor of the esophagus" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss

Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129 * FVB/N * Swiss

 MP:0003387 coarctation of aorta "narrowing of the aorta" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss

 MP:0003393 decreased cardiac output "reduction in the blood volume pumped by each ventricle per minute" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Atp2a2tm1.1Iemr/Atp2a2tm1.1Iemr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0003544 abnormal vascular endothelial cell migration "anomaly in the movement of endothelial cell or their precursors to the appropriate location in the body" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95387]
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Allelic Composition: H2afytm1Peh/H2afytm1Peh,H2afy2tm1.1Peh/H2afy2tm1.1Peh
Genetic Background: 129S6.Cg-H2afy2tm1.1Peh H2afytm1Peh

 MP:0003710 abnormal physiological neovascularization "anomalies in the development of new blood vessels in restoration of blood circulation during the healing process " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: H2afytm1Peh/H2afytm1Peh,H2afy2tm1.1Peh/H2afy2tm1.1Peh
Genetic Background: 129S6.Cg-H2afy2tm1.1Peh H2afytm1Peh

 MP:0003819 increased left ventricle diastolic pressure "increase in the pressure in the left ventricle between heart beats when the heart is relaxed" [RGD:Rat Genome Database submission]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003822 decreased left ventricle systolic pressure "decrease in the pressure in the left ventricle as the heart contracts and pumps blood into the arteries" [RGD:Rat Genome Database submission]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003828 pulmonary edema "an accumulation of an excessive amount of watery fluid in the lung " [J:44108, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Atp2a2tm1Ges/Atp2a2+,Tg(Myh6/tetO-Tnnc1*L48Q)2Jmol/0,Tg(Myh6-tTA)55Rbns/0
Genetic Background: involves: 129X1/SvJ * FVB

 MP:0003923 abnormal left atrium morphology "structural anomaly of the left upper chamber of the heart " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atp2a2tm1.1Iemr/Atp2a2tm1.1Iemr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0004003 abnormal vascular endothelial cell physiology "anomaly in the function of the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: H2afytm1Peh/H2afytm1Peh,H2afy2tm1.1Peh/H2afy2tm1.1Peh
Genetic Background: 129S6.Cg-H2afy2tm1.1Peh H2afytm1Peh

 MP:0004084 abnormal cardiac muscle relaxation "altered ability of the cardiac/heart muscle to lengthen following contractions, often measured by dP/dt min" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss

Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129 * FVB/N * Swiss

 MP:0004207 squamous cell carcinoma "a carcinoma that arises from stratified squamous epithelium that occurs in sites where glandular or columnar epithelium is normally present, such as the skin, esophagus, lungs and cervix" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2a2tm1.1Iemr/Atp2a2tm1.1Iemr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

Allelic Composition: Atp2a2tm1Ges/Atp2a2+,Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol/0,Tg(Myh6-tTA)55Rbns/0
Genetic Background: involves: 129X1/SvJ * FVB

Allelic Composition: Atp2a2tm1Ges/Atp2a2+,Tg(Myh6/tetO-Tnnc1*L48Q)2Jmol/0,Tg(Myh6-tTA)55Rbns/0
Genetic Background: involves: 129X1/SvJ * FVB

 MP:0004231 abnormal calcium ion homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of calcium ions within the body or between a cell and its external environment" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss

Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129 * FVB/N * Swiss

Allelic Composition: Atp2a2tm1.1Raco/Atp2a2+
Genetic Background: C57BL/6J-Atp2a2tm1.1Raco

 MP:0004485 increased response of heart to induced stress "increase in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129 * FVB/N * Swiss

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss

Allelic Composition: Atp2a2tm1.1Iemr/Atp2a2tm1.1Iemr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005156 bradykinesia "decreased spontaneity and movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83301]
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Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129 * FVB/N * Swiss

Allelic Composition: Atp2a2tm1.1Iemr/Atp2a2tm1.1Iemr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0005493 stomach epithelial hyperplasia 
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: H2afytm1Peh/H2afytm1Peh,H2afy2tm1.1Peh/H2afy2tm1.1Peh
Genetic Background: 129S6.Cg-H2afy2tm1.1Peh H2afytm1Peh

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss

 MP:0005665 increased circulating noradrenaline level "greater than the normal blood concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Atp2a2tm1.1Iemr/Atp2a2tm1.1Iemr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129 * FVB/N * Swiss

 MP:0006264 decreased systolic blood pressure "abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]
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Allelic Composition: Atp2a2tm1.1Iemr/Atp2a2tm1.1Iemr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spi1tm4.1Dgt/Spi1tm4.1Dgt
Genetic Background: B6.129(Cg)-Spi1tm4.1Dgt

 MP:0009105 penis prolapse "inability to withdraw the penis into the prepuce (the fold of skin covering the glans penis), other than a paraphimosis; not to be confused with phimosis" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp1a3tm1b(EUCOMM)Hmgu/Atp1a3+
Genetic Background: C57BL/6N-Atp1a3tm1b(EUCOMM)Hmgu/H

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss

 MP:0010403 atrial septal defect "abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]
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Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss

 MP:0010469 ascending aorta hypoplasia "underdevelopment or reduced size of the portion of the aorta that arises from the base of the left ventricle and extends upward to the aortic arch and from which the coronary arteries arise, usually due to reduced cell number" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss

 MP:0010556 thin ventricle myocardium compact layer "reduced thickness of the ventricular portion of the outer, dense layer of the myocardium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss

 MP:0010579 increased heart left ventricle size "greater than average size of the left ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2a2tm1Ges/Atp2a2+,Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol/0,Tg(Myh6-tTA)55Rbns/0
Genetic Background: involves: 129X1/SvJ * FVB

 MP:0010724 thick interventricular septum "increased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2a2tm1Ges/Atp2a2+,Tg(Myh6/tetO-Tnnc1*L48Q)2Jmol/0,Tg(Myh6-tTA)55Rbns/0
Genetic Background: involves: 129X1/SvJ * FVB

 MP:0010754 abnormal heart left ventricle pressure "any anomaly in the pressure within the left cardiac ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2a2tm1.1Iemr/Atp2a2tm1.1Iemr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
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Allelic Composition: H2afytm1Peh/H2afytm1Peh,H2afy2tm1.1Peh/H2afy2tm1.1Peh
Genetic Background: 129S6.Cg-H2afy2tm1.1Peh H2afytm1Peh

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Chrna4tm1Lst/Chrna4+
Genetic Background: involves: C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Atp1a3tm1b(EUCOMM)Hmgu/Atp1a3+
Genetic Background: C57BL/6N-Atp1a3tm1b(EUCOMM)Hmgu/H

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss

 MP:0011952 decreased cardiac stroke volume "reduction in the volume of blood pushed into the aorta with each beat of the heart" [MGI:csmith]
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Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129 * FVB/N * Swiss

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
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Allelic Composition: Atp1a3tm1b(EUCOMM)Hmgu/Atp1a3+
Genetic Background: C57BL/6N-Atp1a3tm1b(EUCOMM)Hmgu/H

 MP:0030257 increased tongue papilloma incidence "greater than the expected number of benign tumors consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic epithelial cells in the tongue" [MGI:anna]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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