ENSDARG00000005122


Danio rerio

Features
Gene ID: ENSDARG00000005122
  
Biological name :atp2a2a
  
Synonyms : atp2a2a / atp2a2b / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2a
  
Possible biological names infered from orthology : ATP2A2 / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 / O55143 / P16615 / Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
  
Species: Danio rerio
  
Chr. number: 21
Strand: 1
Band:
Gene start: 17051478
Gene end: 17108649
  
Corresponding Affymetrix probe sets: Dr.3629.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000136537
Ensembl peptide - ENSDARP00000140204
Ensembl peptide - ENSDARP00000047200
NCBI entrez gene - 568265     See in Manteia.
RefSeq - NM_001030277
RefSeq - XM_005161196
RefSeq Peptide - NP_001025448
swissprot - A0A0R4IQS8
swissprot - Q6ZM60
swissprot - A9C3Q5
ZFIN ID - ZDB-GENE-040426-702
ZFIN ID - ZDB-GENE-030131-867
Ensembl - ENSDARG00000005122
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ATP2A2ENSGALG00000032287Gallus gallus
 ATP2A2ENSG00000174437Homo sapiens
 Atp2a2ENSMUSG00000029467Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
atp2a2a / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2a / ATP2A2* / O55143* / P16615* / Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 * / ATPase sarcoplasmic/endoplas...ENSDARG0000002943985
si:dkey-28b4.8ENSDARG0000000284078
atp2a1 / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1ENSDARG0000002057477
atp2a3 / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 / Q64518* / Q93084* / Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 *ENSDARG0000006097877
atp2a1l / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, likeENSDARG0000003545877
atp2c1 / ATPase secretory pathway Ca2+ transporting 1 / P98194* / Q80XR2* / Calcium-transporting ATPase type 2C member 1 *ENSDARG0000006019731
atp1a3b / ATPase Na+/K+ transporting subunit alpha 3b / P13637* / ATP1A3* / Q6PIC6* / AC010616.2* / ATPase Na+/K+ transporting subunit alpha 3* / Sodium/potassium-transporting ATPase subuni...ENSDARG0000010413928
atp1a1a.2 / ATPase Na+/K+ transporting subunit alpha 1a, tandem duplicate 2 / ATP1A1* / P05023* / Q8VDN2* / ATPase Na+/K+ transporting subunit alpha 1* / Sodium/potassium-transporting ATPas...ENSDARG0000000773928
atp1a3a / ATPase Na+/K+ transporting subunit alpha 3a / P13637* / ATP1A3* / Q6PIC6* / AC010616.2* / ATPase Na+/K+ transporting subunit alpha 3* / Sodium/potassium-transporting ATPase subuni...ENSDARG0000001825928
atp1a1a.5 / ATPase Na+/K+ transporting subunit alpha 1a, tandem duplicate 5 / ATP1A1* / P05023* / Q8VDN2* / ATPase Na+/K+ transporting subunit alpha 1* / Sodium/potassium-transporting ATPas...ENSDARG0000004025228
atp1a1a.3 / ATPase Na+/K+ transporting subunit alpha 1a, tandem duplicate 3 / ATP1A1* / P05023* / Q8VDN2* / ATPase Na+/K+ transporting subunit alpha 1* / Sodium/potassium-transporting ATPas...ENSDARG0000003913128
atp1a1b / ATPase Na+/K+ transporting subunit alpha 1b / ATP1A1* / P05023* / Q8VDN2* / ATPase Na+/K+ transporting subunit alpha 1* / Sodium/potassium-transporting ATPase subunit alpha-1 *ENSDARG0000001985627
atp1a1a.4 / ATPase Na+/K+ transporting subunit alpha 1a, tandem duplicate 4 / ATP1A1* / P05023* / Q8VDN2* / ATPase Na+/K+ transporting subunit alpha 1* / Sodium/potassium-transporting ATPas...ENSDARG0000000187027
atp1a2a / ATPase Na+/K+ transporting subunit alpha 2 / ATP1A2* / P50993* / Q6PIE5* / Sodium/potassium-transporting ATPase subunit alpha-2 *ENSDARG0000001047227
atp1a1a.1 / ATPase Na+/K+ transporting subunit alpha 1a, tandem duplicate 1 / ATP1A1* / P05023* / Q8VDN2* / ATPase Na+/K+ transporting subunit alpha 1* / Sodium/potassium-transporting ATPas...ENSDARG0000000279127


Protein motifs (from Interpro)
Interpro ID Name
 IPR001757  P-type ATPase
 IPR004014  Cation-transporting P-type ATPase, N-terminal
 IPR005782  P-type ATPase, subfamily IIA, SERCA-type
 IPR006068  Cation-transporting P-type ATPase, C-terminal
 IPR008250  P-type ATPase, A domain superfamily
 IPR018303  P-type ATPase, phosphorylation site
 IPR023214  HAD superfamily
 IPR023298  P-type ATPase, transmembrane domain superfamily
 IPR023299  P-type ATPase, cytoplasmic domain N


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0008016 regulation of heart contraction IMP
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0099132 ATP hydrolysis coupled cation transmembrane transport IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005388 calcium-transporting ATPase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Reduction of cytosolic Ca++ levels
Ion homeostasis
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000009 cardiac ventricle cardiac ventricle collapsed , abnormal
cardiac ventricle decreased contractility , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000471 atrium atrium collapsed , abnormal
atrium decreased contractility , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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