ENSDARG00000002791


Danio rerio

Features
Gene ID: ENSDARG00000002791
  
Biological name :atp1a1a.1
  
Synonyms : atp1a1a.1 / ATPase Na+/K+ transporting subunit alpha 1a, tandem duplicate 1
  
Possible biological names infered from orthology : ATP1A1 / ATPase Na+/K+ transporting subunit alpha 1 / P05023 / Q8VDN2 / Sodium/potassium-transporting ATPase subunit alpha-1
  
Species: Danio rerio
  
Chr. number: 1
Strand: 1
Band:
Gene start: 1712140
Gene end: 1793371
  
Corresponding Affymetrix probe sets: Dr.888.1.S1_at (Zebrafish Array)   NM_131686_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000075490
NCBI entrez gene - 64612     See in Manteia.
RefSeq - NM_131686
RefSeq Peptide - NP_571761
swissprot - Q9DGL6
ZFIN ID - ZDB-GENE-001212-1
Ensembl - ENSDARG00000002791
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ATP1A1ENSGALG00000032247Gallus gallus
 ATP1A1ENSG00000163399Homo sapiens
 Atp1a1ENSMUSG00000033161Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
atp1a1b / ATPase Na+/K+ transporting subunit alpha 1b / ATP1A1* / P05023* / Q8VDN2* / ATPase Na+/K+ transporting subunit alpha 1* / Sodium/potassium-transporting ATPase subunit alpha-1 *ENSDARG0000001985692
atp1a1a.4 / ATPase Na+/K+ transporting subunit alpha 1a, tandem duplicate 4 / ATP1A1* / P05023* / Q8VDN2* / ATPase Na+/K+ transporting subunit alpha 1* / Sodium/potassium-transporting ATPas...ENSDARG0000000187090
atp1a3a / ATPase Na+/K+ transporting subunit alpha 3a / P13637* / ATP1A3* / Q6PIC6* / AC010616.2* / ATPase Na+/K+ transporting subunit alpha 3* / Sodium/potassium-transporting ATPase subuni...ENSDARG0000001825985
atp1a3b / ATPase Na+/K+ transporting subunit alpha 3b / P13637* / ATP1A3* / Q6PIC6* / AC010616.2* / ATPase Na+/K+ transporting subunit alpha 3* / Sodium/potassium-transporting ATPase subuni...ENSDARG0000010413984
atp1a1a.3 / ATPase Na+/K+ transporting subunit alpha 1a, tandem duplicate 3 / ATP1A1* / P05023* / Q8VDN2* / ATPase Na+/K+ transporting subunit alpha 1* / Sodium/potassium-transporting ATPas...ENSDARG0000003913184
atp1a2a / ATPase Na+/K+ transporting subunit alpha 2 / ATP1A2* / P50993* / Q6PIE5* / Sodium/potassium-transporting ATPase subunit alpha-2 *ENSDARG0000001047283
atp1a1a.5 / ATPase Na+/K+ transporting subunit alpha 1a, tandem duplicate 5 / ATP1A1* / P05023* / Q8VDN2* / ATPase Na+/K+ transporting subunit alpha 1* / Sodium/potassium-transporting ATPas...ENSDARG0000004025280
atp1a1a.2 / ATPase Na+/K+ transporting subunit alpha 1a, tandem duplicate 2 / ATP1A1* / P05023* / Q8VDN2* / ATPase Na+/K+ transporting subunit alpha 1* / Sodium/potassium-transporting ATPas...ENSDARG0000000773980
atp2a2a / atp2a2b / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2a / ATP2A2* / O55143* / P16615* / Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 * / ATPase sarcoplasmi...ENSDARG0000000512228
atp2c1 / ATPase secretory pathway Ca2+ transporting 1 / P98194* / Q80XR2* / Calcium-transporting ATPase type 2C member 1 *ENSDARG0000006019728
atp2a3 / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 / Q64518* / Q93084* / Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 *ENSDARG0000006097828
si:dkey-28b4.8ENSDARG0000000284028
atp2a2a / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2a / ATP2A2* / O55143* / P16615* / Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 * / ATPase sarcoplasmic/endoplas...ENSDARG0000002943928
atp2a1l / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, likeENSDARG0000003545827
atp2a1 / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1ENSDARG0000002057427


Protein motifs (from Interpro)
Interpro ID Name
 IPR001757  P-type ATPase
 IPR004014  Cation-transporting P-type ATPase, N-terminal
 IPR005775  P-type ATPase subfamily IIC, subunit alpha
 IPR006068  Cation-transporting P-type ATPase, C-terminal
 IPR008250  P-type ATPase, A domain superfamily
 IPR018303  P-type ATPase, phosphorylation site
 IPR023214  HAD superfamily
 IPR023298  P-type ATPase, transmembrane domain superfamily
 IPR023299  P-type ATPase, cytoplasmic domain N


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003143 embryonic heart tube morphogenesis IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0007420 brain development IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0010172 embryonic body morphogenesis IMP
 biological_processGO:0010248 establishment or maintenance of transmembrane electrochemical gradient IEA
 biological_processGO:0010432 bract development IMP
 biological_processGO:0021591 ventricular system development IMP
 biological_processGO:0030198 extracellular matrix organization IMP
 biological_processGO:0030916 otic vesicle formation IMP
 biological_processGO:0030917 midbrain-hindbrain boundary development IMP
 biological_processGO:0035050 embryonic heart tube development IMP
 biological_processGO:0035051 cardiocyte differentiation IMP
 biological_processGO:0048840 otolith development IMP
 biological_processGO:0048854 brain morphogenesis IMP
 biological_processGO:0060974 cell migration involved in heart formation IMP
 biological_processGO:0071599 otic vesicle development IMP
 cellular_componentGO:0005887 integral component of plasma membrane NAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane NAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005391 sodium:potassium-exchanging ATPase activity IMP
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Ion homeostasis
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain surface feature shape , abnormal
brain quality , abnormal
brain morphology , abnormal
brain unstructured , abnormal
brain decreased diameter , abnormal
brain decreased size , abnormal
brain flat , abnormal
brain degenerate , abnormal
Show

 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary morphology , abnormal
Show

 ZFA:0000051 otic vesicle otic vesicle decreased width , abnormal
otic vesicle elongated , abnormal
otic vesicle increased size , abnormal
otic vesicle epithelium morphology , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
pericardium increased size , abnormal
Show

 ZFA:0000084 yolk yolk swollen , abnormal
yolk quality , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
eye quality , abnormal
Show

 ZFA:0000110 fourth ventricle fourth ventricle decreased size , abnormal
fourth ventricle decreased diameter , abnormal
Show

 ZFA:0000112 gut gut quality , abnormal
Show

 ZFA:0000114 heart heart quality , abnormal
heart morphology , abnormal
heart decreased functionality , abnormal
Show

 ZFA:0000115 heart rudiment heart rudiment has fewer parts of type heart rudiment extracellular matrix, abnormal
heart rudiment extracellular matrix composition , abnormal
heart rudiment lacks parts or has fewer parts of type heart rudiment extracellular matrix, abnormal
Show

 ZFA:0000159 tectal ventricle tectal ventricle decreased size , abnormal
Show

 ZFA:0000217 inner ear inner ear decreased size , abnormal
inner ear morphology , abnormal
inner ear lacks all parts of type otolith , abnormal
Show

 ZFA:0000282 sensory system sensory system quality , abnormal
Show

 ZFA:0000360 heart tube heart tube decreased length , abnormal
Show

 ZFA:0000396 nervous system nervous system quality , abnormal
Show

 ZFA:0000431 semicircular canal semicircular canal aplastic , abnormal
Show

 ZFA:0000938 central canal central canal decreased thickness , abnormal
Show

 ZFA:0001094 whole organism whole organism viability , abnormal
whole organism decreased size , abnormal
whole organism degenerate , abnormal
whole organism necrotic , abnormal
whole organism lethal (sensu genetics) , abnormal
Show

 ZFA:0001105 embryonic structure embryonic structure inverted , abnormal
Show

 ZFA:0001114 head head decreased size , abnormal
head surface feature shape , abnormal
Show

 ZFA:0001115 trunk trunk curved dorsal , abnormal
Show

 ZFA:0001117 post-vent region post-vent region curved dorsal , abnormal
post-vent region curved , abnormal
Show

 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton morphology , abnormal
Show

 ZFA:0001259 forebrain ventricle forebrain ventricle decreased size , abnormal
Show

 ZFA:0001261 ventricular system ventricular system structure, cavities , abnormal
ventricular system collapsed , abnormal
ventricular system decreased size , abnormal
Show

 ZFA:0001439 anatomical system anatomical system quality , abnormal
Show

 ZFA:0001617 otolith otolith decreased distance otolith , abnormal
otolith decreased size , abnormal
Show

 ZFA:0009090 pigment cell pigment cell quality , abnormal
Show

 ZFA:0009091 melanocyte melanocyte quality , abnormal
melanocyte morphology , abnormal
Show

 ZFA:0009306 neuroepithelial cell neuroepithelial cell apical part of cell decreased width , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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