ENSG00000163399


Homo sapiens

Features
Gene ID: ENSG00000163399
  
Biological name :ATP1A1
  
Synonyms : ATP1A1 / ATPase Na+/K+ transporting subunit alpha 1 / P05023
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p13.1
Gene start: 116372668
Gene end: 116410261
  
Corresponding Affymetrix probe sets: 220948_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000445306
Ensembl peptide - ENSP00000295598
Ensembl peptide - ENSP00000358506
Ensembl peptide - ENSP00000396236
Ensembl peptide - ENSP00000400124
Ensembl peptide - ENSP00000358508
NCBI entrez gene - 476     See in Manteia.
OMIM - 182310
RefSeq - XM_017001361
RefSeq - NM_000701
RefSeq - NM_001160233
RefSeq - NM_001160234
RefSeq - XM_017001360
RefSeq Peptide - NP_001153706
RefSeq Peptide - NP_000692
RefSeq Peptide - NP_001153705
swissprot - Q5TC05
swissprot - Q5TC02
swissprot - P05023
swissprot - Q5TC01
Ensembl - ENSG00000163399
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atp1a1a.1ENSDARG00000002791Danio rerio
 atp1a1a.2ENSDARG00000007739Danio rerio
 atp1a1a.3ENSDARG00000039131Danio rerio
 atp1a1a.4ENSDARG00000001870Danio rerio
 atp1a1a.5ENSDARG00000040252Danio rerio
 atp1a1bENSDARG00000019856Danio rerio
 ATP1A1ENSGALG00000032247Gallus gallus
 Atp1a1ENSMUSG00000033161Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ATP1A2 / P50993 / ATPase Na+/K+ transporting subunit alpha 2ENSG0000001862587
ATP1A3 / P13637 / ATPase Na+/K+ transporting subunit alpha 3ENSG0000010540987
AC010616.2ENSG0000028550585
ATP1A4 / Q13733 / ATPase Na+/K+ transporting subunit alpha 4ENSG0000013268178
ATP12A / P54707 / ATPase H+/K+ transporting non-gastric alpha2 subunitENSG0000007567364
ATP4A / P20648 / ATPase H+/K+ transporting alpha subunitENSG0000010567563
ATP2A3 / Q93084 / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3ENSG0000007437029
ATP2A2 / P16615 / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2ENSG0000017443728
ATP2C1 / P98194 / ATPase secretory pathway Ca2+ transporting 1ENSG0000001726027
ATP2C2 / O75185 / ATPase secretory pathway Ca2+ transporting 2ENSG0000006427027
ATP2A1 / O14983 / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1ENSG0000019629627


Protein motifs (from Interpro)
Interpro ID Name
 IPR001757  P-type ATPase
 IPR004014  Cation-transporting P-type ATPase, N-terminal
 IPR005775  P-type ATPase subfamily IIC, subunit alpha
 IPR006068  Cation-transporting P-type ATPase, C-terminal
 IPR008250  P-type ATPase, A domain superfamily
 IPR018303  P-type ATPase, phosphorylation site
 IPR023298  P-type ATPase, transmembrane domain superfamily
 IPR023299  P-type ATPase, cytoplasmic domain N
 IPR036412  HAD-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002026 regulation of the force of heart contraction IEA
 biological_processGO:0002028 regulation of sodium ion transport IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0006883 cellular sodium ion homeostasis IDA
 biological_processGO:0008217 regulation of blood pressure IEA
 biological_processGO:0010107 potassium ion import IEA
 biological_processGO:0010248 establishment or maintenance of transmembrane electrochemical gradient IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0030007 cellular potassium ion homeostasis IDA
 biological_processGO:0031947 negative regulation of glucocorticoid biosynthetic process IEA
 biological_processGO:0034220 ion transmembrane transport TAS
 biological_processGO:0036376 sodium ion export across plasma membrane IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0045822 negative regulation of heart contraction IEA
 biological_processGO:0045823 positive regulation of heart contraction IEA
 biological_processGO:0045989 positive regulation of striated muscle contraction IEA
 biological_processGO:0055119 relaxation of cardiac muscle TAS
 biological_processGO:0060081 membrane hyperpolarization IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0071383 cellular response to steroid hormone stimulus IDA
 biological_processGO:0086002 cardiac muscle cell action potential involved in contraction TAS
 biological_processGO:0086004 regulation of cardiac muscle cell contraction IEA
 biological_processGO:0086009 membrane repolarization IDA
 biological_processGO:0086013 membrane repolarization during cardiac muscle cell action potential IC
 biological_processGO:0086064 cell communication by electrical coupling involved in cardiac conduction TAS
 biological_processGO:0090662 ATP hydrolysis coupled transmembrane transport IEA
 biological_processGO:1903416 response to glycoside IDA
 biological_processGO:1903779 regulation of cardiac conduction TAS
 biological_processGO:1990573 potassium ion import across plasma membrane IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005890 sodium:potassium-exchanging ATPase complex TAS
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0014704 intercalated disc IEA
 cellular_componentGO:0016020 membrane TAS
 cellular_componentGO:0016021 integral component of membrane ISS
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030315 T-tubule IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0042383 sarcolemma ISS
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:1903561 extracellular vesicle HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005391 sodium:potassium-exchanging ATPase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding ISS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0030506 ankyrin binding IEA
 molecular_functionGO:0030955 potassium ion binding IEA
 molecular_functionGO:0031402 sodium ion binding IEA
 molecular_functionGO:0043531 ADP binding IEA
 molecular_functionGO:0043548 phosphatidylinositol 3-kinase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051087 chaperone binding IEA
 molecular_functionGO:1990239 steroid hormone binding IDA


Pathways (from Reactome)
Pathway description
Ion homeostasis
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000069849 ATP1B3 / P54709 / ATPase Na+/K+ transporting subunit beta 3  / complex
 ENSG00000129244 ATP1B2 / P14415 / ATPase Na+/K+ transporting subunit beta 2  / complex
 ENSG00000143153 ATP1B1 / P05026 / ATPase Na+/K+ transporting subunit beta 1  / complex






 

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