ENSG00000132681


Homo sapiens

Features
Gene ID: ENSG00000132681
  
Biological name :ATP1A4
  
Synonyms : ATP1A4 / ATPase Na+/K+ transporting subunit alpha 4 / Q13733
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q23.2
Gene start: 160151570
Gene end: 160186977
  
Corresponding Affymetrix probe sets: 1558612_a_at (Human Genome U133 Plus 2.0 Array)   1564241_at (Human Genome U133 Plus 2.0 Array)   1565346_a_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000434272
Ensembl peptide - ENSP00000357060
Ensembl peptide - ENSP00000433094
NCBI entrez gene - 480     See in Manteia.
OMIM - 607321
RefSeq - XM_011509582
RefSeq - NM_001001734
RefSeq - NM_144699
RefSeq Peptide - NP_001001734
RefSeq Peptide - NP_653300
swissprot - Q13733
swissprot - E9PRA5
Ensembl - ENSG00000132681
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Atp1a4ENSMUSG00000007107Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ATP1A2 / P50993 / ATPase Na+/K+ transporting subunit alpha 2ENSG0000001862579
ATP1A1 / P05023 / ATPase Na+/K+ transporting subunit alpha 1ENSG0000016339978
ATP1A3 / P13637 / ATPase Na+/K+ transporting subunit alpha 3ENSG0000010540977
AC010616.2ENSG0000028550576
ATP12A / P54707 / ATPase H+/K+ transporting non-gastric alpha2 subunitENSG0000007567361
ATP4A / P20648 / ATPase H+/K+ transporting alpha subunitENSG0000010567559
ATP2A3 / Q93084 / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3ENSG0000007437029
ATP2A1 / O14983 / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1ENSG0000019629628
ATP2A2 / P16615 / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2ENSG0000017443728
ATP2C2 / O75185 / ATPase secretory pathway Ca2+ transporting 2ENSG0000006427026
ATP2C1 / P98194 / ATPase secretory pathway Ca2+ transporting 1ENSG0000001726026


Protein motifs (from Interpro)
Interpro ID Name
 IPR001757  P-type ATPase
 IPR004014  Cation-transporting P-type ATPase, N-terminal
 IPR005775  P-type ATPase subfamily IIC, subunit alpha
 IPR006068  Cation-transporting P-type ATPase, C-terminal
 IPR008250  P-type ATPase, A domain superfamily
 IPR018303  P-type ATPase, phosphorylation site
 IPR023298  P-type ATPase, transmembrane domain superfamily
 IPR023299  P-type ATPase, cytoplasmic domain N
 IPR036412  HAD-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport TAS
 biological_processGO:0006814 sodium ion transport TAS
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0009566 fertilization IEA
 biological_processGO:0010248 establishment or maintenance of transmembrane electrochemical gradient IEA
 biological_processGO:0015991 ATP hydrolysis coupled proton transport TAS
 biological_processGO:0030317 flagellated sperm motility IDA
 biological_processGO:0030641 regulation of cellular pH IDA
 biological_processGO:0034220 ion transmembrane transport TAS
 biological_processGO:0042391 regulation of membrane potential IEA
 biological_processGO:1903779 regulation of cardiac conduction TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane NAS
 cellular_componentGO:0005890 sodium:potassium-exchanging ATPase complex TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005391 sodium:potassium-exchanging ATPase activity TAS
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Ion homeostasis
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000069849 ATP1B3 / P54709 / ATPase Na+/K+ transporting subunit beta 3  / complex
 ENSG00000129244 ATP1B2 / P14415 / ATPase Na+/K+ transporting subunit beta 2  / complex
 ENSG00000143153 ATP1B1 / P05026 / ATPase Na+/K+ transporting subunit beta 1  / complex






 

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