ENSG00000129244


Homo sapiens

Features
Gene ID: ENSG00000129244
  
Biological name :ATP1B2
  
Synonyms : ATP1B2 / ATPase Na+/K+ transporting subunit beta 2 / P14415
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: p13.1
Gene start: 7646627
Gene end: 7657768
  
Corresponding Affymetrix probe sets: 204311_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000250111
Ensembl peptide - ENSP00000459145
Ensembl peptide - ENSP00000460499
NCBI entrez gene - 482     See in Manteia.
OMIM - 182331
RefSeq - NM_001678
RefSeq - NM_001303263
RefSeq Peptide - NP_001290192
RefSeq Peptide - NP_001669
swissprot - P14415
swissprot - I3L1V9
swissprot - I3L3J8
Ensembl - ENSG00000129244
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atp1b2aENSDARG00000099203Danio rerio
 atp1b2bENSDARG00000034424Danio rerio
 Atp1b2ENSMUSG00000041329Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ATP1B3 / P54709 / ATPase Na+/K+ transporting subunit beta 3ENSG0000006984944
ATP1B4 / Q9UN42 / ATPase Na+/K+ transporting family member beta 4ENSG0000010189240
ATP1B1 / P05026 / ATPase Na+/K+ transporting subunit beta 1ENSG0000014315339
ATP4B / P51164 / ATPase H+/K+ transporting beta subunitENSG0000018600939


Protein motifs (from Interpro)
Interpro ID Name
 IPR000402  Sodium/potassium-transporting ATPase subunit beta


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0006883 cellular sodium ion homeostasis IDA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0010107 potassium ion import IDA
 biological_processGO:0010248 establishment or maintenance of transmembrane electrochemical gradient IEA
 biological_processGO:0030007 cellular potassium ion homeostasis IDA
 biological_processGO:0032781 positive regulation of ATPase activity IDA
 biological_processGO:0034220 ion transmembrane transport TAS
 biological_processGO:0036376 sodium ion export across plasma membrane IDA
 biological_processGO:0050821 protein stabilization IDA
 biological_processGO:0050900 leukocyte migration TAS
 biological_processGO:0086009 membrane repolarization IDA
 biological_processGO:0086064 cell communication by electrical coupling involved in cardiac conduction TAS
 biological_processGO:1901018 positive regulation of potassium ion transmembrane transporter activity IDA
 biological_processGO:1903278 positive regulation of sodium ion export across plasma membrane IDA
 biological_processGO:1903288 positive regulation of potassium ion import IDA
 biological_processGO:1903779 regulation of cardiac conduction TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005890 sodium:potassium-exchanging ATPase complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 molecular_functionGO:0001671 ATPase activator activity IDA
 molecular_functionGO:0005391 sodium:potassium-exchanging ATPase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0051117 ATPase binding IPI


Pathways (from Reactome)
Pathway description
Basigin interactions
Ion homeostasis
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000172270 BSG / P35613 / basigin (Ok blood group)  / reaction / complex
 ENSG00000069849 ATP1B3 / P54709 / ATPase Na+/K+ transporting subunit beta 3  / complex
 ENSG00000143153 ATP1B1 / P05026 / ATPase Na+/K+ transporting subunit beta 1  / complex
 ENSG00000105409 ATP1A3 / P13637 / ATPase Na+/K+ transporting subunit alpha 3  / complex
 ENSG00000163399 ATP1A1 / P05023 / ATPase Na+/K+ transporting subunit alpha 1  / complex
 ENSG00000018625 ATP1A2 / P50993 / ATPase Na+/K+ transporting subunit alpha 2  / complex
 ENSG00000132681 ATP1A4 / Q13733 / ATPase Na+/K+ transporting subunit alpha 4  / complex






 

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