ENSMUSG00000041329


Mus musculus

Features
Gene ID: ENSMUSG00000041329
  
Biological name :Atp1b2
  
Synonyms : Atp1b2 / P14231 / Sodium/potassium-transporting ATPase subunit beta-2
  
Possible biological names infered from orthology : ATPase Na+/K+ transporting subunit beta 2 / P14415
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B3
Gene start: 69599736
Gene end: 69605942
  
Corresponding Affymetrix probe sets: 10387505 (MoGene1.0st)   1422009_at (Mouse Genome 430 2.0 Array)   1435148_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000047353
Ensembl peptide - ENSMUSP00000116290
NCBI entrez gene - 11932     See in Manteia.
MGI - MGI:88109
RefSeq - XM_017314232
RefSeq - NM_013415
RefSeq Peptide - NP_038201
swissprot - P14231
swissprot - Q3UR55
swissprot - I7HIF3
Ensembl - ENSMUSG00000041329
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atp1b2aENSDARG00000099203Danio rerio
 atp1b2bENSDARG00000034424Danio rerio
 ATP1B2ENSG00000129244Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Atp1b3 / P97370 / Sodium/potassium-transporting ATPase subunit beta-3 / P54709* / ATPase Na+/K+ transporting subunit beta 3*ENSMUSG0000003241242
Atp4b / P50992 / Potassium-transporting ATPase subunit beta / P51164* / ATPase H+/K+ transporting beta subunit*ENSMUSG0000003144939
Atp1b4 / Q99ME6 / Protein ATP1B4 / Q9UN42* / ATPase Na+/K+ transporting family member beta 4*ENSMUSG0000001632739
Atp1b1 / P14094 / Sodium/potassium-transporting ATPase subunit beta-1 / P05026* / ATPase Na+/K+ transporting subunit beta 1*ENSMUSG0000002657639


Protein motifs (from Interpro)
Interpro ID Name
 IPR000402  Sodium/potassium-transporting ATPase subunit beta


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0006883 cellular sodium ion homeostasis IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0010107 potassium ion import IEA
 biological_processGO:0010248 establishment or maintenance of transmembrane electrochemical gradient IEA
 biological_processGO:0030007 cellular potassium ion homeostasis IEA
 biological_processGO:0032781 positive regulation of ATPase activity IEA
 biological_processGO:0036376 sodium ion export across plasma membrane IEA
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0086009 membrane repolarization IEA
 biological_processGO:1901018 positive regulation of potassium ion transmembrane transporter activity IEA
 biological_processGO:1903278 positive regulation of sodium ion export across plasma membrane IEA
 biological_processGO:1903288 positive regulation of potassium ion import IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005890 sodium:potassium-exchanging ATPase complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IDA
 molecular_functionGO:0001671 ATPase activator activity IEA
 molecular_functionGO:0005391 sodium:potassium-exchanging ATPase activity IEA
 molecular_functionGO:0051117 ATPase binding IEA


Pathways (from Reactome)
Pathway description
Basigin interactions
Ion homeostasis
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Neurod2tm1Tap/Neurod2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000756 forelimb paralysis "loss of power of voluntary movement in muscles of the forlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Neurod2tm1Tap/Neurod2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000886 abnormal cerebellar granule layer "any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Neurod2tm1Tap/Neurod2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001004 abnormal photoreceptor morphology "structural or developmental anomaly of the receptors sensitive to light " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Neurod2tm1Tap/Neurod2+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Atp1b2tm1(Atp1b1)Mtg/Atp1b2tm1(Atp1b1)Mtg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Neurod2tm1Tap/Neurod2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Neurod2tm1Tap/Neurod2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
Show

Allelic Composition: Neurod2tm1Tap/Neurod2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005176 eyelids fail to open "eyes remain shut throughout life" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:83500]
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Allelic Composition: Neurod2tm1Tap/Neurod2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005277 abnormal brainstem morphology "anomalous structure of the midbrain, pons, or medulla" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82670]
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Allelic Composition: Neurod2tm1Tap/Neurod2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Neurod2tm1Tap/Neurod2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0006069 abnormal retinal neuronal layer morphology "malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]
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Allelic Composition: Atp1b2tm1(Atp1b1)Mtg/Atp1b2tm1(Atp1b1)Mtg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008450 retinal photoreceptor degeneration "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Neurod2tm1Tap/Neurod2+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Atp1b2tm1(Atp1b1)Mtg/Atp1b2tm1(Atp1b1)Mtg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Neurod2tm1Tap/Neurod2+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Atp1b2tm1(Atp1b1)Mtg/Atp1b2tm1(Atp1b1)Mtg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008518 retinal outer nuclear layer degeneration "a retrogressive impairment or destruction of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Neurod2tm1Tap/Neurod2+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Atp1b2tm1(Atp1b1)Mtg/Atp1b2tm1(Atp1b1)Mtg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Neurod2tm1Tap/Neurod2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008536 enlarged third ventricle "increased size of the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [MESH:A08.186.211.276.840, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Neurod2tm1Tap/Neurod2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008582 short photoreceptor inner segment "decreased length of the photoreceptor region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Neurod2tm1Tap/Neurod2+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Atp1b2tm1(Atp1b1)Mtg/Atp1b2tm1(Atp1b1)Mtg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008587 short photoreceptor outer segment "decreased length of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Neurod2tm1Tap/Neurod2+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Atp1b2tm1(Atp1b1)Mtg/Atp1b2tm1(Atp1b1)Mtg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Neurod2tm1Tap/Neurod2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0030005 increased retinal apoptosis "increase in the number of cells in the retina undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Atp1b2tm1(Atp1b1)Mtg/Atp1b2tm1(Atp1b1)Mtg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026576 Atp1b1 / P14094 / Sodium/potassium-transporting ATPase subunit beta-1 / P05026* / ATPase Na+/K+ transporting subunit beta 1*  / complex
 ENSMUSG00000032412 Atp1b3 / P97370 / Sodium/potassium-transporting ATPase subunit beta-3 / P54709* / ATPase Na+/K+ transporting subunit beta 3*  / complex
 ENSMUSG00000023175 Bsg / P18572 / Basigin / P35613* / basigin (Ok blood group)*  / complex / reaction
 ENSMUSG00000033161 Atp1a1 / Q8VDN2 / Sodium/potassium-transporting ATPase subunit alpha-1 / P05023* / ATPase Na+/K+ transporting subunit alpha 1*  / complex
 ENSMUSG00000007097 Atp1a2 / Q6PIE5 / Sodium/potassium-transporting ATPase subunit alpha-2 / P50993* / ATPase Na+/K+ transporting subunit alpha 2*  / complex
 ENSMUSG00000040907 Atp1a3 / Q6PIC6 / Sodium/potassium-transporting ATPase subunit alpha-3 / P13637* / AC010616.2* / ATPase Na+/K+ transporting subunit alpha 3*  / complex
 ENSMUSG00000007107 Atp1a4 / Q9WV27 / Sodium/potassium-transporting ATPase subunit alpha-4 / Q13733* / ATPase Na+/K+ transporting subunit alpha 4*  / complex






 

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