ENSMUSG00000007097


Mus musculus

Features
Gene ID: ENSMUSG00000007097
  
Biological name :Atp1a2
  
Synonyms : Atp1a2 / Q6PIE5 / Sodium/potassium-transporting ATPase subunit alpha-2
  
Possible biological names infered from orthology : ATPase Na+/K+ transporting subunit alpha 2 / P50993
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H3
Gene start: 172271709
Gene end: 172298064
  
Corresponding Affymetrix probe sets: 10360270 (MoGene1.0st)   1427465_at (Mouse Genome 430 2.0 Array)   1434893_at (Mouse Genome 430 2.0 Array)   1443823_s_at (Mouse Genome 430 2.0 Array)   1452308_a_at (Mouse Genome 430 2.0 Array)   1455136_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000095072
Ensembl peptide - ENSMUSP00000083077
NCBI entrez gene - 98660     See in Manteia.
MGI - MGI:88106
RefSeq - NM_178405
RefSeq Peptide - NP_848492
swissprot - D3YYN7
swissprot - Q3UHK5
swissprot - Q6PIE5
Ensembl - ENSMUSG00000007097
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atp1a2aENSDARG00000010472Danio rerio
 ATP1A2ENSG00000018625Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Atp1a1 / Q8VDN2 / Sodium/potassium-transporting ATPase subunit alpha-1 / P05023* / ATPase Na+/K+ transporting subunit alpha 1*ENSMUSG0000003316187
Atp1a3 / Q6PIC6 / Sodium/potassium-transporting ATPase subunit alpha-3 / P13637* / AC010616.2* / ATPase Na+/K+ transporting subunit alpha 3*ENSMUSG0000004090786
Atp1a4 / Q9WV27 / Sodium/potassium-transporting ATPase subunit alpha-4 / Q13733* / ATPase Na+/K+ transporting subunit alpha 4*ENSMUSG0000000710780
Atp12a / Q9Z1W8 / Potassium-transporting ATPase alpha chain 2 / P54707* / ATPase H+/K+ transporting non-gastric alpha2 subunit*ENSMUSG0000002222965
Atp4a / ATPase H+/K+ transporting alpha subunit / P20648*ENSMUSG0000000555363
Atp2a3 / Q64518 / Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 / Q93084* / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3*ENSMUSG0000002078830
Atp2a2 / O55143 / Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 / P16615* / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2*ENSMUSG0000002946728
Atp2a1 / Q8R429 / Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 / O14983* / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1*ENSMUSG0000003073028
Atp2c1 / Q80XR2 / Calcium-transporting ATPase type 2C member 1 / P98194* / ATPase secretory pathway Ca2+ transporting 1*ENSMUSG0000003257027
A7L9Z8 / Atp2c2 / Calcium-transporting ATPase type 2C member 2 / O75185* / ATPase secretory pathway Ca2+ transporting 2*ENSMUSG0000003411227


Protein motifs (from Interpro)
Interpro ID Name
 IPR001757  P-type ATPase
 IPR004014  Cation-transporting P-type ATPase, N-terminal
 IPR005775  P-type ATPase subfamily IIC, subunit alpha
 IPR006068  Cation-transporting P-type ATPase, C-terminal
 IPR008250  P-type ATPase, A domain superfamily
 IPR018303  P-type ATPase, phosphorylation site
 IPR023298  P-type ATPase, transmembrane domain superfamily
 IPR023299  P-type ATPase, cytoplasmic domain N
 IPR036412  HAD-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001504 neurotransmitter uptake IMP
 biological_processGO:0002026 regulation of the force of heart contraction IMP
 biological_processGO:0002087 regulation of respiratory gaseous exchange by neurological system process IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0006883 cellular sodium ion homeostasis IEA
 biological_processGO:0006937 regulation of muscle contraction IMP
 biological_processGO:0006940 regulation of smooth muscle contraction IMP
 biological_processGO:0006942 regulation of striated muscle contraction IMP
 biological_processGO:0008217 regulation of blood pressure IGI
 biological_processGO:0008344 adult locomotory behavior IMP
 biological_processGO:0008542 visual learning IMP
 biological_processGO:0010107 potassium ion import IEA
 biological_processGO:0010248 establishment or maintenance of transmembrane electrochemical gradient IEA
 biological_processGO:0015991 ATP hydrolysis coupled proton transport IEA
 biological_processGO:0019229 regulation of vasoconstriction IMP
 biological_processGO:0030007 cellular potassium ion homeostasis IEA
 biological_processGO:0035094 response to nicotine IEA
 biological_processGO:0036376 sodium ion export across plasma membrane IEA
 biological_processGO:0040011 locomotion IMP
 biological_processGO:0045822 negative regulation of heart contraction IMP
 biological_processGO:0045988 negative regulation of striated muscle contraction IMP
 biological_processGO:0046034 ATP metabolic process IEA
 biological_processGO:0051481 negative regulation of cytosolic calcium ion concentration IMP
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0071383 cellular response to steroid hormone stimulus IDA
 biological_processGO:0086004 regulation of cardiac muscle cell contraction IEA
 biological_processGO:1903170 negative regulation of calcium ion transmembrane transport IEA
 biological_processGO:1903280 negative regulation of calcium:sodium antiporter activity IEA
 biological_processGO:1903416 response to glycoside IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005890 sodium:potassium-exchanging ATPase complex IEA
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0014704 intercalated disc IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030315 T-tubule IEA
 cellular_componentGO:0042383 sarcolemma IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005391 sodium:potassium-exchanging ATPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0019829 cation-transporting ATPase activity IEA
 molecular_functionGO:0030955 potassium ion binding IEA
 molecular_functionGO:0031402 sodium ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051087 chaperone binding IEA
 molecular_functionGO:1990239 steroid hormone binding IEA


Pathways (from Reactome)
Pathway description
Ion homeostasis
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000230 abnormal blood pressure "altered tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sh3kbp1tm1Kuro/Sh3kbp1tm1Kuro,Cd79atm1(cre)Reth/Cd79a+,Gt(ROSA)26Sortm4(Ikbkb)Rsky/?
Genetic Background: involves: BALB/c * C57BL/6 * NZB

 MP:0000818 abnormal amygdala morphology "any malformation or absence of the almond-shaped body of basal nuclei anterior to the inferior horn of the lateral ventricle of the brain, within the temporal lobe; this area is involved in aggression and fear responses" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pfn1tm1Wit/Pfn1+
Genetic Background: B6.129S4-Pfn1tm1Wit

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
Show

Allelic Composition: Dkk1tm1Lmgd/Dkk1tm1Lmgd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001404 no spontaneous movement "failure to make any change in position or posture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Foxm1tm1.1Rhc/Foxm1tm1.1Rhc
Genetic Background: involves: 129X1/SvJ

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Dkk1tm1Lmgd/Dkk1tm1Lmgd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001491 unresponsive to tactile stimuli "absence of reflex action normally induced by touch or pain" [J:43515, J:47439]
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Allelic Composition: Foxm1tm1.1Rhc/Foxm1tm1.1Rhc
Genetic Background: involves: 129X1/SvJ

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Sh3kbp1tm1Kuro/Sh3kbp1tm1Kuro,Cd79atm1(cre)Reth/Cd79a+,Gt(ROSA)26Sortm4(Ikbkb)Rsky/?
Genetic Background: involves: BALB/c * C57BL/6 * NZB

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Foxm1tm1.1Rhc/Foxm1tm1.1Rhc
Genetic Background: involves: 129X1/SvJ

 MP:0002065 abnormal fear/anxiety-related behavior "altered response in tests for fear or anxiety related behaviors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atp1a2tm1Kwk/Atp1a2tm1Kwk
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atp1a2tm2Kwk/Atp1a2tm2Kwk
Genetic Background: B6.129X1-Atp1a2tm2Kwk

 MP:0002204 abnormal neurotransmitter physiology "aberrant function or production of endogenous signaling molecules secreted by neurons that alter the behavior of neurons or effector cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Foxm1tm1.1Rhc/Foxm1tm1.1Rhc
Genetic Background: involves: 129X1/SvJ

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxm1tm1.1Rhc/Foxm1tm1.1Rhc
Genetic Background: involves: 129X1/SvJ

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Sh3kbp1tm1Kuro/Sh3kbp1tm1Kuro,Cd79atm1(cre)Reth/Cd79a+,Gt(ROSA)26Sortm4(Ikbkb)Rsky/?
Genetic Background: involves: BALB/c * C57BL/6 * NZB

 MP:0002972 abnormal cardiac muscle contractility "altered ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Scn8anur14/Scn8anur14
Genetic Background: involves: C57BL/6J

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Juntm4Wag/Juntm4Wag,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0005267 abnormal olfactory cortex morphology "anomalous structure of piriform cortex, part of the olfactory tract, which receives its major afferents from the olfactory bulb, and is primarily responsible for the identification of odors" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83884]
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Allelic Composition: Pfn1tm1Wit/Pfn1+
Genetic Background: B6.129S4-Pfn1tm1Wit

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxm1tm1.1Rhc/Foxm1tm1.1Rhc
Genetic Background: involves: 129X1/SvJ

 MP:0005423 abnormal somatic nervous system physiology "anomalous function of any of the cranial and spinal nerves or their ganglia or the peripheral sensory receptors" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Foxm1tm1.1Rhc/Foxm1tm1.1Rhc
Genetic Background: involves: 129X1/SvJ

 MP:0005599 increased cardiac muscle contractility "greater than the normal ability of the heart muscle to shorten or to develop increased tension " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,Plautm1Mlg/Plautm1Mlg
Genetic Background: involves: 129 * C57BL/6

 MP:0005620 abnormal muscle contractility "aberrant ability of a muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mfge8tm1Osa/Mfge8tm1Osa
Genetic Background: B6.129-Mfge8tm1Osa

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Juntm4Wag/Juntm4Wag,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Atp1a2tm1Kwk/Atp1a2tm1Kwk
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Atp1a2tm2Kwk/Atp1a2tm2Kwk
Genetic Background: B6.129X1-Atp1a2tm2Kwk

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026576 Atp1b1 / P14094 / Sodium/potassium-transporting ATPase subunit beta-1 / P05026* / ATPase Na+/K+ transporting subunit beta 1*  / complex
 ENSMUSG00000032412 Atp1b3 / P97370 / Sodium/potassium-transporting ATPase subunit beta-3 / P54709* / ATPase Na+/K+ transporting subunit beta 3*  / complex
 ENSMUSG00000041329 Atp1b2 / P14231 / Sodium/potassium-transporting ATPase subunit beta-2 / P14415* / ATPase Na+/K+ transporting subunit beta 2*  / complex






 

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