ENSMUSG00000032570


Mus musculus

Features
Gene ID: ENSMUSG00000032570
  
Biological name :Atp2c1
  
Synonyms : Atp2c1 / Calcium-transporting ATPase type 2C member 1 / Q80XR2
  
Possible biological names infered from orthology : ATPase secretory pathway Ca2+ transporting 1 / P98194
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: F1
Gene start: 105403539
Gene end: 105527319
  
Corresponding Affymetrix probe sets: 10596347 (MoGene1.0st)   1431196_at (Mouse Genome 430 2.0 Array)   1434386_at (Mouse Genome 430 2.0 Array)   1437738_at (Mouse Genome 430 2.0 Array)   1439215_at (Mouse Genome 430 2.0 Array)   1442742_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135802
Ensembl peptide - ENSMUSP00000039103
Ensembl peptide - ENSMUSP00000082220
Ensembl peptide - ENSMUSP00000108177
Ensembl peptide - ENSMUSP00000129617
Ensembl peptide - ENSMUSP00000134764
Ensembl peptide - ENSMUSP00000134902
Ensembl peptide - ENSMUSP00000135010
Ensembl peptide - ENSMUSP00000135170
Ensembl peptide - ENSMUSP00000135320
Ensembl peptide - ENSMUSP00000135646
Ensembl peptide - ENSMUSP00000135732
NCBI entrez gene - 235574     See in Manteia.
MGI - MGI:1889008
RefSeq - XM_006511714
RefSeq - NM_001253831
RefSeq - NM_001253834
RefSeq - NM_001253836
RefSeq - NM_175025
RefSeq - XM_006511710
RefSeq - XM_006511711
RefSeq - XM_006511712
RefSeq Peptide - NP_778190
RefSeq Peptide - NP_001240760
RefSeq Peptide - NP_001240763
RefSeq Peptide - NP_001240765
swissprot - H3BJJ5
swissprot - H3BJY0
swissprot - H3BKB1
swissprot - H3BL44
swissprot - H3BLC2
swissprot - H3BLI6
swissprot - Q3UZR5
swissprot - H3BJ99
swissprot - Q80XR2
swissprot - Q8BMS7
swissprot - H3BIX7
Ensembl - ENSMUSG00000032570
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atp2c1ENSDARG00000060197Danio rerio
 ATP2C1ENSGALG00000034340Gallus gallus
 ATP2C1ENSG00000017260Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
A7L9Z8 / Atp2c2 / Calcium-transporting ATPase type 2C member 2 / O75185* / ATPase secretory pathway Ca2+ transporting 2*ENSMUSG0000003411262
Atp2a2 / O55143 / Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 / P16615* / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2*ENSMUSG0000002946734
Atp2a3 / Q64518 / Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 / Q93084* / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3*ENSMUSG0000002078834
Atp2a1 / Q8R429 / Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 / O14983* / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1*ENSMUSG0000003073033
Atp1a4 / Q9WV27 / Sodium/potassium-transporting ATPase subunit alpha-4 / Q13733* / ATPase Na+/K+ transporting subunit alpha 4*ENSMUSG0000000710729
Atp1a2 / Q6PIE5 / Sodium/potassium-transporting ATPase subunit alpha-2 / P50993* / ATPase Na+/K+ transporting subunit alpha 2*ENSMUSG0000000709729
Atp4a / ATPase H+/K+ transporting alpha subunit / P20648*ENSMUSG0000000555329
Atp1a1 / Q8VDN2 / Sodium/potassium-transporting ATPase subunit alpha-1 / P05023* / ATPase Na+/K+ transporting subunit alpha 1*ENSMUSG0000003316129
Atp1a3 / Q6PIC6 / Sodium/potassium-transporting ATPase subunit alpha-3 / P13637* / AC010616.2* / ATPase Na+/K+ transporting subunit alpha 3*ENSMUSG0000004090729
Atp12a / Q9Z1W8 / Potassium-transporting ATPase alpha chain 2 / P54707* / ATPase H+/K+ transporting non-gastric alpha2 subunit*ENSMUSG0000002222927


Protein motifs (from Interpro)
Interpro ID Name
 IPR001757  P-type ATPase
 IPR004014  Cation-transporting P-type ATPase, N-terminal
 IPR006068  Cation-transporting P-type ATPase, C-terminal
 IPR006413  P-type ATPase, subfamily IIA, PMR1-type
 IPR008250  P-type ATPase, A domain superfamily
 IPR018303  P-type ATPase, phosphorylation site
 IPR023214  HAD superfamily
 IPR023298  P-type ATPase, transmembrane domain superfamily
 IPR023299  P-type ATPase, cytoplasmic domain N
 IPR030336  Calcium-transporting ATPase type 2C member 1
 IPR036412  HAD-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006828 manganese ion transport ISS
 biological_processGO:0006874 cellular calcium ion homeostasis IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008544 epidermis development IEA
 biological_processGO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IEA
 biological_processGO:0030026 cellular manganese ion homeostasis ISO
 biological_processGO:0031532 actin cytoskeleton reorganization IEA
 biological_processGO:0032468 Golgi calcium ion homeostasis IEA
 biological_processGO:0032472 Golgi calcium ion transport IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling ISS
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0071421 manganese ion transmembrane transport IEA
 biological_processGO:0099132 ATP hydrolysis coupled cation transmembrane transport IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005802 trans-Golgi network IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032580 Golgi cisterna membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004871 obsolete signal transducer activity ISS
 molecular_functionGO:0005388 calcium-transporting ATPase activity IEA
 molecular_functionGO:0005509 calcium ion binding ISS
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0015410 manganese-transporting ATPase activity ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030145 manganese ion binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002051 skin papilloma "a circumscribed, benign epithelial tumor projecting from the surrounding surface" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003277 esophageal papilloma "benign epithelial tumor of the esophagus" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004207 squamous cell carcinoma "a carcinoma that arises from stratified squamous epithelium that occurs in sites where glandular or columnar epithelium is normally present, such as the skin, esophagus, lungs and cervix" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009378 abnormal endoplasmic reticulum morphology "any structural anomaly of irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells" [GO:0005783]
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011260 abnormal head mesenchyme morphology "any structural anomaly of the primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells" [ISBN:0-683-40008-8]
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011743 abnormal Golgi apparatus morphology "any structural anomaly of the compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack; Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations" [GO:0005794, MGI:mberry]
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0012505 increased neural tube apoptosis "increase in the number of cells of the neural tube undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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