ENSMUSG00000040907


Mus musculus

Features
Gene ID: ENSMUSG00000040907
  
Biological name :Atp1a3
  
Synonyms : Atp1a3 / Q6PIC6 / Sodium/potassium-transporting ATPase subunit alpha-3
  
Possible biological names infered from orthology : AC010616.2 / ATPase Na+/K+ transporting subunit alpha 3 / P13637
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A3
Gene start: 24978167
Gene end: 25005958
  
Corresponding Affymetrix probe sets: 10560919 (MoGene1.0st)   1424856_at (Mouse Genome 430 2.0 Array)   1427481_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000079691
Ensembl peptide - ENSMUSP00000099922
Ensembl peptide - ENSMUSP00000143735
NCBI entrez gene - 232975     See in Manteia.
MGI - MGI:88107
RefSeq - XM_011250520
RefSeq - NM_001290469
RefSeq - XM_011250518
RefSeq - XM_011250519
RefSeq Peptide - NP_001277398
swissprot - Q8VCE0
swissprot - A0A0G2JGX4
swissprot - Q6PIC6
Ensembl - ENSMUSG00000040907
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atp1a3aENSDARG00000018259Danio rerio
 atp1a3bENSDARG00000104139Danio rerio
 AC010616.2ENSG00000285505Homo sapiens
 ATP1A3ENSG00000105409Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Atp1a2 / Q6PIE5 / Sodium/potassium-transporting ATPase subunit alpha-2 / P50993* / ATPase Na+/K+ transporting subunit alpha 2*ENSMUSG0000000709787
Atp1a1 / Q8VDN2 / Sodium/potassium-transporting ATPase subunit alpha-1 / P05023* / ATPase Na+/K+ transporting subunit alpha 1*ENSMUSG0000003316186
Atp1a4 / Q9WV27 / Sodium/potassium-transporting ATPase subunit alpha-4 / Q13733* / ATPase Na+/K+ transporting subunit alpha 4*ENSMUSG0000000710777
Atp4a / ATPase H+/K+ transporting alpha subunit / P20648*ENSMUSG0000000555365
Atp12a / Q9Z1W8 / Potassium-transporting ATPase alpha chain 2 / P54707* / ATPase H+/K+ transporting non-gastric alpha2 subunit*ENSMUSG0000002222965
Atp2a3 / Q64518 / Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 / Q93084* / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3*ENSMUSG0000002078829
Atp2a2 / O55143 / Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 / P16615* / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2*ENSMUSG0000002946729
Atp2a1 / Q8R429 / Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 / O14983* / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1*ENSMUSG0000003073028
A7L9Z8 / Atp2c2 / Calcium-transporting ATPase type 2C member 2 / O75185* / ATPase secretory pathway Ca2+ transporting 2*ENSMUSG0000003411227
Atp2c1 / Q80XR2 / Calcium-transporting ATPase type 2C member 1 / P98194* / ATPase secretory pathway Ca2+ transporting 1*ENSMUSG0000003257027


Protein motifs (from Interpro)
Interpro ID Name
 IPR001757  P-type ATPase
 IPR004014  Cation-transporting P-type ATPase, N-terminal
 IPR005775  P-type ATPase subfamily IIC, subunit alpha
 IPR006068  Cation-transporting P-type ATPase, C-terminal
 IPR008250  P-type ATPase, A domain superfamily
 IPR018303  P-type ATPase, phosphorylation site
 IPR023298  P-type ATPase, transmembrane domain superfamily
 IPR023299  P-type ATPase, cytoplasmic domain N
 IPR036412  HAD-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0006883 cellular sodium ion homeostasis IDA
 biological_processGO:0007613 memory IMP
 biological_processGO:0008344 adult locomotory behavior IMP
 biological_processGO:0008542 visual learning IMP
 biological_processGO:0010107 potassium ion import ISO
 biological_processGO:0010248 establishment or maintenance of transmembrane electrochemical gradient IEA
 biological_processGO:0021987 cerebral cortex development IEA
 biological_processGO:0030007 cellular potassium ion homeostasis ISO
 biological_processGO:0035235 ionotropic glutamate receptor signaling pathway IMP
 biological_processGO:0036376 sodium ion export across plasma membrane IDA
 biological_processGO:0042493 response to drug IMP
 biological_processGO:0060048 cardiac muscle contraction IDA
 biological_processGO:0071300 cellular response to retinoic acid IEA
 biological_processGO:0086036 regulation of cardiac muscle cell membrane potential IGI
 biological_processGO:0097067 cellular response to thyroid hormone stimulus IEA
 biological_processGO:1904646 cellular response to amyloid-beta IEA
 biological_processGO:1990535 neuron projection maintenance ISO
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0005890 sodium:potassium-exchanging ATPase complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0042383 sarcolemma IDA
 cellular_componentGO:0043025 neuronal cell body ISO
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0044326 dendritic spine neck IEA
 cellular_componentGO:0044327 dendritic spine head IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001540 amyloid-beta binding IEA
 molecular_functionGO:0005391 sodium:potassium-exchanging ATPase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0031748 D1 dopamine receptor binding IEA
 molecular_functionGO:0043395 heparan sulfate proteoglycan binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051087 chaperone binding ISO
 molecular_functionGO:0086037 sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential IGI


Pathways (from Reactome)
Pathway description
Ion homeostasis
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000801 abnormal temporal lobe morphology "malformation or absence of the lower lateral part of the cerebral hemisphere" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Atp1a3Myk/Atp1a3+
Genetic Background: B6NCr.129S1-Atp1a3Myk

Allelic Composition: Atp1a3Myk/Atp1a3+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J * C57BL/6NCr

 MP:0000947 convulsive seizures "seizures characterized by uncontrolled motor activity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pdx1tm1Macd/Pdx1+,Tg(tetO-Sox17,-EGFP)1Jaw/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Atp1a3Myk/Atp1a3+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J * C57BL/6NCr

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Pdx1tm1Macd/Pdx1+,Tg(tetO-Sox17,-EGFP)1Jaw/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Atp1a3Myk/Atp1a3+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J * C57BL/6NCr

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Pdx1tm1Macd/Pdx1+,Tg(tetO-Sox17,-EGFP)1Jaw/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Atp1a3Myk/Atp1a3+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J * C57BL/6NCr

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Pdx1tm1Macd/Pdx1+,Tg(tetO-Sox17,-EGFP)1Jaw/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Dkk1tm1Lmgd/Dkk1tm1Lmgd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Atp1a3Myk/Atp1a3+
Genetic Background: B6NCr.129S1-Atp1a3Myk

Allelic Composition: Atp1a3tm1.1Kwk/Atp1a3+
Genetic Background: B6JJcl.Cg-Atp1a3tm1.1Kwk

Allelic Composition: Atp1a3tm1b(EUCOMM)Hmgu/Atp1a3+
Genetic Background: C57BL/6N-Atp1a3tm1b(EUCOMM)Hmgu/H

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Atp1a3Myk/Atp1a3+
Genetic Background: B6NCr.129S1-Atp1a3Myk

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Dkk1tm1Lmgd/Dkk1tm1Lmgd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001486 abnormal startle reflex "abberant threshold or reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Pdx1tm1Macd/Pdx1+,Tg(tetO-Sox17,-EGFP)1Jaw/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001501 abnormal sleep pattern "deviation from the normal wake/sleep cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pdx1tm1Macd/Pdx1+,Tg(tetO-Sox17,-EGFP)1Jaw/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pdx1tm1Macd/Pdx1+,Tg(tetO-Sox17,-EGFP)1Jaw/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Atp1a3Myk/Atp1a3tm1Ling
Genetic Background: involves: 129S1/SvImJ * C57BL/6J * C57BL/6NCr

Allelic Composition: Atp1a3Myk/Atp1a3+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J * C57BL/6NCr

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Atp1a3tm1.1Kwk/Atp1a3+
Genetic Background: B6JJcl.Cg-Atp1a3tm1.1Kwk

 MP:0002327 abnormal respiratory function "anomaly in any measure of the processes involved in respiration" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tshrhyt-3J/Tshrhyt-3J
Genetic Background: CByJ;CXB10-Tshrhyt-3J/GrsrJ

 MP:0002634 abnormal sensorimotor gating "malfunction of the process by which inhibitory neural pathways filter multiple stimuli and allow attention to be focused on one stimulus; usually measured by pre-pulse inhibition (PPI)" [J:42758, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Atp1a3Myk/Atp1a3+
Genetic Background: B6NCr.129S1-Atp1a3Myk

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Atp1a3Myk/Atp1a3tm1Ling
Genetic Background: involves: 129S1/SvImJ * C57BL/6J * C57BL/6NCr

 MP:0003461 abnormal response to novel object "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Atp1a3Myk/Atp1a3+
Genetic Background: B6NCr.129S1-Atp1a3Myk

 MP:0003858 enhanced coordination "improved ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atp1a3tm1.1Kwk/Atp1a3+
Genetic Background: B6JJcl.Cg-Atp1a3tm1.1Kwk

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Atp1a3Myk/Atp1a3+
Genetic Background: B6NCr.129S1-Atp1a3Myk

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp1a3Myk/Atp1a3+
Genetic Background: B6NCr.129S1-Atp1a3Myk

Allelic Composition: Atp1a3tm1b(EUCOMM)Hmgu/Atp1a3+
Genetic Background: C57BL/6N-Atp1a3tm1b(EUCOMM)Hmgu/H

 MP:0005323 dystonia "impairment of muscle tone resulting in prolonged muscle contraction and involuntary movements such as repetitive movements, or twisting or writhing of the limbs" [J:84533]
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Allelic Composition: Atp1a3tm1.1Kwk/Atp1a3+
Genetic Background: B6JJcl.Cg-Atp1a3tm1.1Kwk

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Atp1a3Myk/Atp1a3+
Genetic Background: B6NCr.129S1-Atp1a3Myk

 MP:0008840 abnormal spike wave discharge "anomaly in the characteristic epileptiformic electroencephalographic (EEG) activity detected in generalized absence epilepsy" [PMID:16725200]
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Allelic Composition: Atp1a3Myk/Atp1a3+
Genetic Background: B6NCr.129S1-Atp1a3Myk

Allelic Composition: Atp1a3Myk/Atp1a3+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J * C57BL/6NCr

 MP:0008875 abnormal pharmacokinetics of xenobiotics "any anomaly in the absorbtion, distribution, metabolism or elimination of a foreign compound" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp1a3tm1.1Kwk/Atp1a3+
Genetic Background: B6JJcl.Cg-Atp1a3tm1.1Kwk

 MP:0008918 microgliosis "a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp1a3Myk/Atp1a3tm1Ling
Genetic Background: involves: 129S1/SvImJ * C57BL/6J * C57BL/6NCr

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp1a3Myk/Atp1a3+
Genetic Background: B6NCr.129S1-Atp1a3Myk

 MP:0009357 induced seizures "applied stimulation producing uncontrolled electrical activity in the brain, producing a physical convulsion or minor change in physical behavior" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp1a3Myk/Atp1a3+
Genetic Background: B6NCr.129S1-Atp1a3Myk

 MP:0009358 environmentally induced seizures "relatively mild but sudden stimulation due to changes in ambient habitat including lighting, sounds, touching, and/ or moving cage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp1a3Myk/Atp1a3+
Genetic Background: B6NCr.129S1-Atp1a3Myk

Allelic Composition: Atp1a3Myk/Atp1a3+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J * C57BL/6NCr

 MP:0009435 abnormal miniature inhibitory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an inhibitory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp1a3tm1.1Kwk/Atp1a3+
Genetic Background: B6JJcl.Cg-Atp1a3tm1.1Kwk

 MP:0009713 enhanced conditioned place preference behavior "increase in the ability of an animal to learn and remember an association between a putative rewarding internal state produced by a xenobiotic or drug with a neutral, unchanging environment" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp1a3Myk/Atp1a3+
Genetic Background: B6NCr.129S1-Atp1a3Myk

 MP:0009749 enhanced behavioral response to addictive substance "increased sensitivity to an addictive substance capable of inducing the appearance of behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dkk1tm1Lmgd/Dkk1tm1Lmgd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0009940 abnormal hippocampus pyramidal cell morphology "any structural anomaly of the projection neuron in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp1a3Myk/Atp1a3+
Genetic Background: B6NCr.129S1-Atp1a3Myk

Allelic Composition: Atp1a3Myk/Atp1a3+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J * C57BL/6NCr

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Dkk1tm1Lmgd/Dkk1tm1Lmgd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Atp1a3Myk/Atp1a3Myk
Genetic Background: involves: 129S1/SvImJ * C57BL/6J * C57BL/6NCr

Allelic Composition: Atp1a3tm1.1Kwk/Atp1a3tm1.1Kwk
Genetic Background: B6JJcl.Cg-Atp1a3tm1.1Kwk

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Atp1a3tm1b(EUCOMM)Hmgu/Atp1a3+
Genetic Background: C57BL/6N-Atp1a3tm1b(EUCOMM)Hmgu/H

 MP:0011617 abnormal habituation "anomaly in the process in which there is a progressive decline of behavioral response probability with a repetitive stimulus" [GO:0046959, PMID:16774787]
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Allelic Composition: Atp1a3Myk/Atp1a3+
Genetic Background: B6NCr.129S1-Atp1a3Myk

 MP:0011624 abnormal sensitization to xenobiotic "anomaly in the process in which a progressive amplification of a behavioral response follows repeated administration of a xenobiotic" [MGI:csmith]
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Allelic Composition: Atp1a3Myk/Atp1a3+
Genetic Background: B6NCr.129S1-Atp1a3Myk

 MP:0012286 decreased frequency of paradoxical sleep "decreased incidence or duration of the sleep stage in which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity" [http://orcid.org/0000-0001-5208-3432]
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Allelic Composition: Atp1a3Myk/Atp1a3+
Genetic Background: B6NCr.129S1-Atp1a3Myk

 MP:0012288 abnormal paradoxical sleep pattern "any anomaly in the frequency or duration of the sleep stage in which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity" [MGI:csmith]
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Allelic Composition: Atp1a3Myk/Atp1a3+
Genetic Background: B6NCr.129S1-Atp1a3Myk

 MP:0012289 abnormal non-rapid eye movement sleep pattern "any anomaly in the frequency or duration of the sleep stages characterized by distinct EEG patterns, decreased metabolic activity, slowed breathing and heart rate, and the absence of rapid eye movement and dreaming" [MGI:csmith]
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Allelic Composition: Atp1a3Myk/Atp1a3+
Genetic Background: B6NCr.129S1-Atp1a3Myk

 MP:0020469 prolonged circadian behavior period "increase in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [MGI:smb]
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Allelic Composition: Atp1a3Myk/Atp1a3+
Genetic Background: B6NCr.129S1-Atp1a3Myk

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026576 Atp1b1 / P14094 / Sodium/potassium-transporting ATPase subunit beta-1 / P05026* / ATPase Na+/K+ transporting subunit beta 1*  / complex
 ENSMUSG00000032412 Atp1b3 / P97370 / Sodium/potassium-transporting ATPase subunit beta-3 / P54709* / ATPase Na+/K+ transporting subunit beta 3*  / complex
 ENSMUSG00000041329 Atp1b2 / P14231 / Sodium/potassium-transporting ATPase subunit beta-2 / P14415* / ATPase Na+/K+ transporting subunit beta 2*  / complex






 

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