ENSMUSG00000007107


Mus musculus

Features
Gene ID: ENSMUSG00000007107
  
Biological name :Atp1a4
  
Synonyms : Atp1a4 / Q9WV27 / Sodium/potassium-transporting ATPase subunit alpha-4
  
Possible biological names infered from orthology : ATPase Na+/K+ transporting subunit alpha 4 / Q13733
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H3
Gene start: 172223513
Gene end: 172258414
  
Corresponding Affymetrix probe sets: 10360248 (MoGene1.0st)   1437321_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000106874
NCBI entrez gene - 27222     See in Manteia.
MGI - MGI:1351335
RefSeq - NM_013734
RefSeq - XM_006496874
RefSeq Peptide - NP_038762
swissprot - Q9WV27
Ensembl - ENSMUSG00000007107
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ATP1A4ENSG00000132681Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Atp1a2 / Q6PIE5 / Sodium/potassium-transporting ATPase subunit alpha-2 / P50993* / ATPase Na+/K+ transporting subunit alpha 2*ENSMUSG0000000709779
Atp1a1 / Q8VDN2 / Sodium/potassium-transporting ATPase subunit alpha-1 / P05023* / ATPase Na+/K+ transporting subunit alpha 1*ENSMUSG0000003316178
Atp1a3 / Q6PIC6 / Sodium/potassium-transporting ATPase subunit alpha-3 / P13637* / AC010616.2* / ATPase Na+/K+ transporting subunit alpha 3*ENSMUSG0000004090776
Atp12a / Q9Z1W8 / Potassium-transporting ATPase alpha chain 2 / P54707* / ATPase H+/K+ transporting non-gastric alpha2 subunit*ENSMUSG0000002222961
Atp4a / ATPase H+/K+ transporting alpha subunit / P20648*ENSMUSG0000000555359
Atp2a3 / Q64518 / Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 / Q93084* / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3*ENSMUSG0000002078829
Atp2a1 / Q8R429 / Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 / O14983* / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1*ENSMUSG0000003073028
Atp2a2 / O55143 / Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 / P16615* / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2*ENSMUSG0000002946728
A7L9Z8 / Atp2c2 / Calcium-transporting ATPase type 2C member 2 / O75185* / ATPase secretory pathway Ca2+ transporting 2*ENSMUSG0000003411227
Atp2c1 / Q80XR2 / Calcium-transporting ATPase type 2C member 1 / P98194* / ATPase secretory pathway Ca2+ transporting 1*ENSMUSG0000003257026


Protein motifs (from Interpro)
Interpro ID Name
 IPR001757  P-type ATPase
 IPR004014  Cation-transporting P-type ATPase, N-terminal
 IPR005775  P-type ATPase subfamily IIC, subunit alpha
 IPR006068  Cation-transporting P-type ATPase, C-terminal
 IPR008250  P-type ATPase, A domain superfamily
 IPR018303  P-type ATPase, phosphorylation site
 IPR023298  P-type ATPase, transmembrane domain superfamily
 IPR023299  P-type ATPase, cytoplasmic domain N
 IPR036412  HAD-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0006814 sodium ion transport IMP
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0009566 fertilization IMP
 biological_processGO:0010248 establishment or maintenance of transmembrane electrochemical gradient IEA
 biological_processGO:0030317 flagellated sperm motility IEA
 biological_processGO:0030641 regulation of cellular pH IEA
 biological_processGO:0042391 regulation of membrane potential IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005391 sodium:potassium-exchanging ATPase activity ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Ion homeostasis
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Trp53tm1.1Awbr/Trp53tm1.1Awbr
Genetic Background: involves: C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Trp53tm1.1Awbr/Trp53tm1.1Awbr
Genetic Background: involves: C57BL/6

Allelic Composition: Atp1a4tm1Blac/Atp1a4tm1Blac
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm1.1Awbr/Trp53tm1.1Awbr
Genetic Background: involves: C57BL/6

Allelic Composition: Atp1a4tm1Itl/Atp1a4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003666 impaired sperm capacitation "anomaly in the change undergone by spermatozoa in the female genital tract that enables them to penetrate and fertilize an egg" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96669]
Show

Allelic Composition: Trp53tm1.1Awbr/Trp53tm1.1Awbr
Genetic Background: involves: C57BL/6

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Atp1a3tm1b(EUCOMM)Hmgu/Atp1a3+
Genetic Background: C57BL/6N-Atp1a3tm1b(EUCOMM)Hmgu/H

 MP:0004543 abnormal sperm physiology "anomaly in the normal function of spermatozoa" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp53tm1.1Awbr/Trp53tm1.1Awbr
Genetic Background: involves: C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Atp1a3tm1b(EUCOMM)Hmgu/Atp1a3+
Genetic Background: C57BL/6N-Atp1a3tm1b(EUCOMM)Hmgu/H

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm1.1Awbr/Trp53tm1.1Awbr
Genetic Background: involves: C57BL/6

 MP:0009237 kinked sperm flagellum "a sharp bend or zigzag in the sperm tail" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp53tm1.1Awbr/Trp53tm1.1Awbr
Genetic Background: involves: C57BL/6

Allelic Composition: Atp1a4tm1Blac/Atp1a4tm1Blac
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0009282 reduced hyperactivated sperm motility "loss or reduction of the hyperactivated type of sperm mobility, impairing the ability of sperm to reach the site of fertilization and to penetrate the oocyte vestments; a block in hyperactivated motility may also impair the ability of a sperm to fertilize an oocyte in vitro" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atp1a4tm1Blac/Atp1a4tm1Blac
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026576 Atp1b1 / P14094 / Sodium/potassium-transporting ATPase subunit beta-1 / P05026* / ATPase Na+/K+ transporting subunit beta 1*  / complex
 ENSMUSG00000032412 Atp1b3 / P97370 / Sodium/potassium-transporting ATPase subunit beta-3 / P54709* / ATPase Na+/K+ transporting subunit beta 3*  / complex
 ENSMUSG00000041329 Atp1b2 / P14231 / Sodium/potassium-transporting ATPase subunit beta-2 / P14415* / ATPase Na+/K+ transporting subunit beta 2*  / complex






 

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