ENSMUSG00000030730


Mus musculus

Features
Gene ID: ENSMUSG00000030730
  
Biological name :Atp2a1
  
Synonyms : Atp2a1 / Q8R429 / Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
  
Possible biological names infered from orthology : ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 / O14983
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F3
Gene start: 126445858
Gene end: 126463108
  
Corresponding Affymetrix probe sets: 10567879 (MoGene1.0st)   1419312_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032974
Ensembl peptide - ENSMUSP00000119018
NCBI entrez gene - 11937     See in Manteia.
MGI - MGI:105058
RefSeq - NM_007504
RefSeq - XM_006507268
RefSeq Peptide - NP_031530
swissprot - F6RQN3
swissprot - Q8R429
Ensembl - ENSMUSG00000030730
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ATP2A1ENSG00000196296Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Atp2a2 / O55143 / Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 / P16615* / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2*ENSMUSG0000002946785
Atp2a3 / Q64518 / Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 / Q93084* / ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3*ENSMUSG0000002078876
Atp2c1 / Q80XR2 / Calcium-transporting ATPase type 2C member 1 / P98194* / ATPase secretory pathway Ca2+ transporting 1*ENSMUSG0000003257032
A7L9Z8 / Atp2c2 / Calcium-transporting ATPase type 2C member 2 / O75185* / ATPase secretory pathway Ca2+ transporting 2*ENSMUSG0000003411231
Atp1a4 / Q9WV27 / Sodium/potassium-transporting ATPase subunit alpha-4 / Q13733* / ATPase Na+/K+ transporting subunit alpha 4*ENSMUSG0000000710729
Atp1a2 / Q6PIE5 / Sodium/potassium-transporting ATPase subunit alpha-2 / P50993* / ATPase Na+/K+ transporting subunit alpha 2*ENSMUSG0000000709729
Atp4a / ATPase H+/K+ transporting alpha subunit / P20648*ENSMUSG0000000555329
Atp1a1 / Q8VDN2 / Sodium/potassium-transporting ATPase subunit alpha-1 / P05023* / ATPase Na+/K+ transporting subunit alpha 1*ENSMUSG0000003316129
Atp1a3 / Q6PIC6 / Sodium/potassium-transporting ATPase subunit alpha-3 / P13637* / AC010616.2* / ATPase Na+/K+ transporting subunit alpha 3*ENSMUSG0000004090729
Atp12a / Q9Z1W8 / Potassium-transporting ATPase alpha chain 2 / P54707* / ATPase H+/K+ transporting non-gastric alpha2 subunit*ENSMUSG0000002222928


Protein motifs (from Interpro)
Interpro ID Name
 IPR001757  P-type ATPase
 IPR004014  Cation-transporting P-type ATPase, N-terminal
 IPR005782  P-type ATPase, subfamily IIA, SERCA-type
 IPR006068  Cation-transporting P-type ATPase, C-terminal
 IPR008250  P-type ATPase, A domain superfamily
 IPR018303  P-type ATPase, phosphorylation site
 IPR023214  HAD superfamily
 IPR023298  P-type ATPase, transmembrane domain superfamily
 IPR023299  P-type ATPase, cytoplasmic domain N
 IPR036412  HAD-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport ISO
 biological_processGO:0006937 regulation of muscle contraction TAS
 biological_processGO:0006942 regulation of striated muscle contraction ISS
 biological_processGO:0008637 apoptotic mitochondrial changes IEA
 biological_processGO:0031448 positive regulation of fast-twitch skeletal muscle fiber contraction IEA
 biological_processGO:0032470 positive regulation of endoplasmic reticulum calcium ion concentration IEA
 biological_processGO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration IEA
 biological_processGO:0034976 response to endoplasmic reticulum stress IEA
 biological_processGO:0045988 negative regulation of striated muscle contraction ISS
 biological_processGO:0051561 positive regulation of mitochondrial calcium ion concentration IEA
 biological_processGO:0051659 maintenance of mitochondrion location IEA
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IEA
 biological_processGO:0070509 calcium ion import IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0090076 relaxation of skeletal muscle IEA
 biological_processGO:0099132 ATP hydrolysis coupled cation transmembrane transport IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISS
 cellular_componentGO:0005789 endoplasmic reticulum membrane ISO
 cellular_componentGO:0005793 endoplasmic reticulum-Golgi intermediate compartment ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016529 sarcoplasmic reticulum IDA
 cellular_componentGO:0031673 H zone ISO
 cellular_componentGO:0031674 I band ISS
 cellular_componentGO:0033017 sarcoplasmic reticulum membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005388 calcium-transporting ATPase activity ISO
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding ISS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016887 ATPase activity ISS
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Reduction of cytosolic Ca++ levels
Ion homeostasis
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
Show

Allelic Composition: Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0002279 abnormal diaphragm morphology "structural defect in the thin musculomebraneous barrier that separates the abdominal and thoracic cavities; these muscles often used for breathing control" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0002841 impaired skeletal muscle contractility "inability or reduced ability of the skeletal muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0003157 impaired muscle relaxation "reduced or absent ability of muscle to lengthen following contractions" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92510]
Show

Allelic Composition: Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0003646 muscle fatigue "increased muscle exhaustion or increased susceptibility to muscle exhaustion" [J:96306]
Show

Allelic Composition: Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Portm1Wolf/Portm1Wolf,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Atp1a3tm1b(EUCOMM)Hmgu/Atp1a3+
Genetic Background: C57BL/6N-Atp1a3tm1b(EUCOMM)Hmgu/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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